ID A0A2I2YJQ0_GORGO Unreviewed; 1136 AA.
AC A0A2I2YJQ0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=CD163 molecule {ECO:0000313|Ensembl:ENSGGOP00000035109.1};
GN Name=CD163 {ECO:0000313|Ensembl:ENSGGOP00000035109.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000035109.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000035109.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000035109.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000035109.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR EMBL; CABD030082600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030082601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2YJQ0; -.
DR Ensembl; ENSGGOT00000056092.1; ENSGGOP00000035109.1; ENSGGOG00000024564.2.
DR GeneTree; ENSGT00940000155987; -.
DR Proteomes; UP000001519; Chromosome 12.
DR Bgee; ENSGGOG00000024564; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.10.250.10; SRCR-like domain; 9.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR48071; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48071:SF15; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00530; SRCR; 9.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 9.
DR SUPFAM; SSF56487; SRCR-like; 9.
DR PROSITE; PS00420; SRCR_1; 4.
DR PROSITE; PS50287; SRCR_2; 9.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1031..1051
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..132
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 139..239
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 246..346
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 353..453
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 458..558
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 563..663
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 699..799
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 804..906
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 909..1009
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DISULFID 100..110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 164..228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 177..238
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 208..218
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 271..335
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 284..345
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 315..325
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 378..442
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 391..452
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 422..432
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 483..547
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 496..557
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 527..537
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 588..652
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 601..662
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 632..642
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 724..788
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 737..798
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 768..778
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 844..905
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 875..885
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 934..998
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 947..1008
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 978..988
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 1136 AA; 123349 MW; EFE70A5FC334BF0F CRC64;
MDRTRMVLKS DNVKNNFLLA LCDLGGTDKE LRLVDGENKC SGRVEVKVQE EWGTVCNNGW
SMEAVSVICN QLGCPTAIKA TGWANSSAGS GRIWMDHVSC RGNESALWDC KHDGWGKHSN
CTHQQDAGVT CSDGSNLEMR LMNGGNMCSG RIEIKFQGRW GTVCDDNFNI DHASVICRQL
ECGSAVSFSG SSNFGEGSGP IWFDDLICNG NESALWNCKH QGWGKHNCDH AEDAGVICSK
GADLSLRLVD GVTECSGRLE VRFQGEWGTI CDDGWDSYDA AVACKQLGCP TAITAIGRVN
ASEGFGHIWL DSVSCQGHEP AVWQCKHHEW GKHYCNHNED AGVTCSDGSD LELRLRGGGS
RCAGTVEVEI QRLLGKVCDR GWGLKEADVV CRQLGCGSAL KTSYQVYSKI QATNTWLFLS
SCNGNETSLW DCKNWQWGGL TCDHYEEAKI TCSAHREPRL VGGDIPCSGR VEVKHGDMWG
SVCDSDFSLE AASVLCRELQ CGTVVSILGG AHFGEGNGQI WAEEFQCEGH ESHLSLCPVA
PRPEGTCSHS RDVGVVCSRY TEIRLVNGKT PCEGRVELKT LGAWGSLCNS HWDIEDAHVL
CQQLKCGVAL STPGGAHFGK GNGQVWRHMF HCTGTEQHMG DCPVTALGAS LCPSEQVASV
ICSGNQSQTL SSCNSSSLGP TRPTIPEESA VACIESGQLR LVNGGGRCAG RVEIYHEGSW
GTICDDNWDL SDAHVVCRQL GCGEAINATG SAHFGEGTGP IWLDEMKCNG KESRIWQCHS
HGWGQQNCRH KEDAGVICSE FMSLRLTSEA SREACAGRLE VFYNGAWGSV GKSSMSETTV
GVVCRQLGCA DKGKINPASL DKAMSIPMWV DNVQCPKGPD TLWQCPSSPW EKRLASPSEE
TWITCDNKIR LQEGPTSCSG RVEIWHGGSW GTVCDDSWDL DDAQVVCQQL GCGPALKAFK
EAEFGQGTGP IWLNEVKCKG NESSLWDCPA RRWGHNECGH KEDAAVNCTH ISVQKTPQKA
TTGRSSHQSS FIAVGILGVV LLAIFVALFF LTKKRRQRQQ LAVSSRGENL VHQIQYREMN
SCLNADDLDL MNSSENSHES ADFSAAELIS VSKFLPISGM EKEAILSHTE KENGNL
//
