ID A0A2I2YL68_GORGO Unreviewed; 944 AA.
AC A0A2I2YL68;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=PHD finger protein 14 {ECO:0000313|Ensembl:ENSGGOP00000035635.1};
GN Name=PHF14 {ECO:0000313|Ensembl:ENSGGOP00000035635.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000035635.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000035635.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000035635.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000035635.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030049871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030049872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030049873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030049874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030049875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030049876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018887148.1; XM_019031603.1.
DR AlphaFoldDB; A0A2I2YL68; -.
DR STRING; 9593.ENSGGOP00000035635; -.
DR Ensembl; ENSGGOT00000068579.1; ENSGGOP00000035635.1; ENSGGOG00000006206.3.
DR GeneID; 101125340; -.
DR KEGG; ggo:101125340; -.
DR CTD; 9678; -.
DR GeneTree; ENSGT00940000156923; -.
DR InParanoid; A0A2I2YL68; -.
DR OMA; LVMCDEC; -.
DR OrthoDB; 163389at2759; -.
DR Proteomes; UP000001519; Chromosome 7.
DR Bgee; ENSGGOG00000006206; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0002314; P:germinal center B cell differentiation; IEA:Ensembl.
DR GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
DR GO; GO:0060916; P:mesenchymal cell proliferation involved in lung development; IEA:Ensembl.
DR GO; GO:2000791; P:negative regulation of mesenchymal cell proliferation involved in lung development; IEA:Ensembl.
DR GO; GO:2000584; P:negative regulation of platelet-derived growth factor receptor-alpha signaling pathway; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd15674; ePHD_PHF14; 1.
DR CDD; cd15561; PHD1_PHF14; 1.
DR CDD; cd15562; PHD2_PHF14; 1.
DR CDD; cd15563; PHD3_PHF14; 1.
DR Gene3D; 2.30.30.1150; -; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793:SF150; PHD FINGER PROTEIN 14; 1.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR Pfam; PF00628; PHD; 2.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 4.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 3.
DR PROSITE; PS50016; ZF_PHD_2; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 317..378
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 380..497
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 723..777
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 866..919
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 22..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 628..676
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 70..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..254
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..860
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 918..944
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 944 AA; 106486 MW; 262FD18F4F81CB91 CRC64;
MDRSSKRRQV KPLAASLLEA LDYDSSDDSD FKVGDASDSE GSGNGSEDAS KDSGEGSCSD
SEENILEEEL NEDIKVKEEQ LKNSAEEEVL SSEKQLIKME KKEEEENGER PRKKKEKEKE
KEKEKEKERE KEKEKATVSE NVAASAAATT PATSPPAVNT SPSVPTTTTA TEEQVSEPKK
WNLRRNRPLL DFVSMEELND MDDYDSEDDN DWRPTVVKRK GRSASQKEGS DGDNEDDEDE
GSGSDEDEND EGNDEDHSSP ASEGGCKKKK SKVLSRNSAD DEELTNDSLT LSQSKSNEDS
LILEKSQNWS SQKMDHILIC CVCLGDNSED ADEIIQCDNC GITVHEGCYG VDGESDSIMS
SASENSTEPW FCDACKCGVS PSCELCPNQD GIFKETDAGR WVHIVCALYV PGVAFGDIDK
LRPVTLTEMN YSKYGAKECS FCEDPRFART GVCISCDAGM CRAYFHVTCA QKEGLLSEAA
AEEDIADPFF AYCKQHADRL DRKWKRKNYL ALQSYCKMSL QEREKQLSPE AQARINARLQ
QYRAKAELAR STRPQAWVPR EKLPRPLTSS ASAIRKLMRK AELMGISTDI FPVDNSDTSS
SVDGRRKHKQ PALTADFVNY YFERNMRMIQ IQENMAEQKN IKDKLENEQE KLHVEYNKLC
ESLEELQNLN GKLRSEGQGI WALLGRITGQ KLNIPAILRA PKERKPSKKE GGTQKTSTLP
AVLYSCGICK KNHDQHLLLL CDTCKLHYHL GCLDPPLTRM PRKTKNSYWQ CSECDQAGSS
DMEADMAMET LPDGTKRSRR QIKEPVKFVP QDVPPEPKKI PIRNTRTRGR KRSFVPEEEK
HEERVPRERR QRQSVLQKKP KAEDLRTECA TCKGTGDNEN LVRCDECRLC YHFGCLDPPL
KKSPKQTGYG WICQECDSSS SKEDEAERKN ISQELNMEQK NPKK
//
