ID A0A2I2YLH0_GORGO Unreviewed; 861 AA.
AC A0A2I2YLH0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Membrane associated guanylate kinase, WW and PDZ domain containing 2 {ECO:0000313|Ensembl:ENSGGOP00000035786.1};
GN Name=MAGI2 {ECO:0000313|Ensembl:ENSGGOP00000035786.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000035786.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000035786.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000035786.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000035786.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030053981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030053982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030053983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030053984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030053985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030053986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030053987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030053988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030053989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030053990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2YLH0; -.
DR Ensembl; ENSGGOT00000064573.1; ENSGGOP00000035786.1; ENSGGOG00000001298.4.
DR GeneTree; ENSGT00940000155057; -.
DR Proteomes; UP000001519; Chromosome 7.
DR Bgee; ENSGGOG00000001298; Expressed in prefrontal cortex and 5 other cell types or tissues.
DR CDD; cd00992; PDZ_signaling; 5.
DR Gene3D; 2.30.42.10; -; 5.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF27; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00595; PDZ; 5.
DR SMART; SM00228; PDZ; 5.
DR SUPFAM; SSF50156; PDZ domain-like; 5.
DR PROSITE; PS50106; PDZ; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 35..104
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 214..277
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 371..453
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 513..603
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 740..822
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 462..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..650
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 861 AA; 94511 MW; 4EBA94561511CB38 CRC64;
MPHTELGTKP LQAPGFREKP LFTRDASQLK GTFLSTTLKK SNMGFGFTII GGDEPDEFLQ
VKSVIPDGPA AQDGKMETGD VIVYINEVCV LGHTHADVVK LFQSVPIGQS VNLVLCRGYP
LPFDPEDPAN SMVPPLAIME RPPPVMVNGR HNYETYLEYI SRTSQSVPDI TDRPPHSLHS
MPTDGQLDGT YPPPVHDDNV SMASSGATQA ELMTLTIVKG AQGFGFTIAD SPTGQRVKQI
LDIQGCPGLC EGDLIVEINQ QNVQNLSHTE VVDILKDCPI GSETSLIIHR GGKTNTGSAI
KYIMDRWENQ GSPQTSLSAP AIPQNLPFPP ALHRSSFPDS TEAFDPRKPD PYELYEKSRA
IYESPDYKEL DVHLRRMESG FGFRILGGDE PGQPILIGAV IAMGSADRDG RLHPGDELVY
VDGIPVAGKT HRYVIDLMHH AARNGQVNLT VRRKVLCGGE PCPENGRSPG SVSTHHSSPR
SDYATYTNSN HAAPSSNASP PEGFASHSLQ TSDVVIHRKE NEGFGFVIIS SLNRPESGST
ITVPHKIGRI IDGSPADRCA KLKVGDRILA VNGQSIINMP HADIVKLIKD AGLSVTLRII
PQEELNSPTS APSSEKQSPM AQQSPLAQQS PLAQPSPATP NSPIAQPAPP QPLQLQGHEN
SYRSEVKARQ DVKPDIRQPP FTDYRQPPLD YRQPPGGDYQ QPPPLDYRQP PLLDYRQHSP
DTRQYPLSDY RQPQDFDYFT VDMEKGAKGF GFSIRGGREY KMDLYVLRLA EDGPAIRNGR
MRVGDQIIEI NGESTRDMTH ARAIELIKSG GRRVRLLLKR GTGQVPEYGA FHVLIHPFAL
PSVNHKCLCL FIKLHQFSIS T
//
