ID A0A2I2YMB9_GORGO Unreviewed; 405 AA.
AC A0A2I2YMB9;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=SH3 and PX domains 2B {ECO:0000313|Ensembl:ENSGGOP00000036076.1};
GN Name=SH3PXD2B {ECO:0000313|Ensembl:ENSGGOP00000036076.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000036076.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000036076.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000036076.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000036076.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030042384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030042385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030042386; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030042387; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030042388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2YMB9; -.
DR Ensembl; ENSGGOT00000043405.1; ENSGGOP00000036076.1; ENSGGOG00000008765.3.
DR GeneTree; ENSGT00940000158396; -.
DR Proteomes; UP000001519; Chromosome 5.
DR Bgee; ENSGGOG00000008765; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd12075; SH3_Tks4_1; 1.
DR CDD; cd12076; SH3_Tks4_2; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035477; SH3PXD2B_SH3_1.
DR InterPro; IPR035478; SH3PXD2B_SH3_2.
DR PANTHER; PTHR15706:SF25; SH3 AND PX DOMAIN-CONTAINING PROTEIN 2B; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 2.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..104
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 127..186
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 196..255
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 250..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 405 AA; 46128 MW; 66EE15311B275EF6 CRC64;
VYIIRVTWSS GSTEAIYRRY SKFFDLQMQM LDKFPMEGGQ KDPKQRIIPF LPGKILFRRS
HIRDVAVKRL IPIDEYCKAL IQLPPYISQC DEVLQFFETR PEDLNPPKEE HIGKKKSGGD
QTSVDPMVLE QYVVVANYQK QESSEISLSV GQVVDIIEKN ESGWWFVSTA EEQGWVPATC
LEGQDGVQDE FSLQPEEEEK YTVIYPYTAR DQDEMNLERG AVVEVIQKNL EGWWKIRYQG
KEGWAPASYL KKNSGEPLPP KPGPGSPSHP GALDLDGVSR QQNAVGREKE LLSSQRDGRF
EGRPVPDGDA KQRSPKMRQR PPPRRDMTIP RGLNLPKPPI PPQVEEEYYT IAEFQTTIPD
GISFQAGLKV EDHKNVHLES PVEVPLRRIK MRTALGKHVG ASMEM
//
