ID A0A2I2YMW9_GORGO Unreviewed; 461 AA.
AC A0A2I2YMW9;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Solute carrier family 41 member {ECO:0000256|RuleBase:RU369007};
GN Name=SLC41A3 {ECO:0000313|Ensembl:ENSGGOP00000036312.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000036312.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000036312.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000036312.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000036312.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a magnesium transporter.
CC {ECO:0000256|RuleBase:RU369007}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU369007}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369007}.
CC -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC {ECO:0000256|ARBA:ARBA00009749, ECO:0000256|RuleBase:RU369007}.
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DR EMBL; CABD030023908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030023909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2YMW9; -.
DR Ensembl; ENSGGOT00000056777.1; ENSGGOP00000036312.1; ENSGGOG00000007490.3.
DR GeneTree; ENSGT00950000183042; -.
DR OMA; NLEFCFQ; -.
DR Proteomes; UP000001519; Chromosome 3.
DR Bgee; ENSGGOG00000007490; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015693; P:magnesium ion transport; IEA:UniProt.
DR Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 2.
DR InterPro; IPR006667; SLC41_membr_dom.
DR InterPro; IPR036739; SLC41_membr_dom_sf.
DR InterPro; IPR045349; SLC41A1-3.
DR PANTHER; PTHR16228; DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41; 1.
DR PANTHER; PTHR16228:SF22; SOLUTE CARRIER FAMILY 41 MEMBER 3; 1.
DR Pfam; PF01769; MgtE; 2.
DR SUPFAM; SSF161093; MgtE membrane domain-like; 2.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU369007};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU369007};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369007};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369007};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369007};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU369007}.
FT TRANSMEM 36..61
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 122..145
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 157..184
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 196..219
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 258..277
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 289..308
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 351..370
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 382..399
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 419..444
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT DOMAIN 80..213
FT /note="SLC41A/MgtE integral membrane"
FT /evidence="ECO:0000259|Pfam:PF01769"
FT DOMAIN 293..436
FT /note="SLC41A/MgtE integral membrane"
FT /evidence="ECO:0000259|Pfam:PF01769"
SQ SEQUENCE 461 AA; 49935 MW; 6BCEA59D5E7C7130 CRC64;
MVVTQLNLEF CFQGKKLRGF SCELTRSPRG VLPESFFTIM CQVVVPILLS GLCMMTAGLV
MNTVQHWPVF VEVKDLLTLV PPLVGLKGNL EMTLASRLST AANTGQIDDP QEQHRVISSN
LALIQVQATV VGLLAAVAAL LLGVVSREEV DVAKVELLCA SSVLTAFLAA FALGVLMVCI
VIGARKLGVN PDNIATPIAA SLGDLITLSI LALVSSFFYR HKDSRYLTPL VCLSFAALTP
VWVLIAKQSP PIVKILKFGW FPIILAMVIS SFGGLILSKT VSKQQYKGMA IFTPVICGVG
GNLVAIQTSR ISTYLHMWSA PGVLPLQMKK FWPNPCSTFC TSEINSMSAR VLLLLVVPGH
LIFFYIIYLV EGQSVINSQT FLVLYLLAGL IQVTILLYLA EVMVRLTWHQ ALDPDNHCIP
YLTGLGDLLG TGLLALCFFT DWLLKSKAEL GGISELASGP P
//