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Database: UniProt
Entry: A0A2I2YMW9_GORGO
LinkDB: A0A2I2YMW9_GORGO
Original site: A0A2I2YMW9_GORGO 
ID   A0A2I2YMW9_GORGO        Unreviewed;       461 AA.
AC   A0A2I2YMW9;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Solute carrier family 41 member {ECO:0000256|RuleBase:RU369007};
GN   Name=SLC41A3 {ECO:0000313|Ensembl:ENSGGOP00000036312.1};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000036312.1, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000036312.1, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000036312.1, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA   Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA   Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA   Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA   Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA   Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA   Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA   Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA   Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA   Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA   Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000036312.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Acts as a magnesium transporter.
CC       {ECO:0000256|RuleBase:RU369007}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU369007}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369007}.
CC   -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC       {ECO:0000256|ARBA:ARBA00009749, ECO:0000256|RuleBase:RU369007}.
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DR   EMBL; CABD030023908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030023909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2I2YMW9; -.
DR   Ensembl; ENSGGOT00000056777.1; ENSGGOP00000036312.1; ENSGGOG00000007490.3.
DR   GeneTree; ENSGT00950000183042; -.
DR   OMA; NLEFCFQ; -.
DR   Proteomes; UP000001519; Chromosome 3.
DR   Bgee; ENSGGOG00000007490; Expressed in cerebellum and 6 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015693; P:magnesium ion transport; IEA:UniProt.
DR   Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 2.
DR   InterPro; IPR006667; SLC41_membr_dom.
DR   InterPro; IPR036739; SLC41_membr_dom_sf.
DR   InterPro; IPR045349; SLC41A1-3.
DR   PANTHER; PTHR16228; DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41; 1.
DR   PANTHER; PTHR16228:SF22; SOLUTE CARRIER FAMILY 41 MEMBER 3; 1.
DR   Pfam; PF01769; MgtE; 2.
DR   SUPFAM; SSF161093; MgtE membrane domain-like; 2.
PE   3: Inferred from homology;
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU369007};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU369007};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369007};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU369007};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU369007};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU369007}.
FT   TRANSMEM        36..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   TRANSMEM        122..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   TRANSMEM        157..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   TRANSMEM        196..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   TRANSMEM        258..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   TRANSMEM        289..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   TRANSMEM        351..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   TRANSMEM        382..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   TRANSMEM        419..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   DOMAIN          80..213
FT                   /note="SLC41A/MgtE integral membrane"
FT                   /evidence="ECO:0000259|Pfam:PF01769"
FT   DOMAIN          293..436
FT                   /note="SLC41A/MgtE integral membrane"
FT                   /evidence="ECO:0000259|Pfam:PF01769"
SQ   SEQUENCE   461 AA;  49935 MW;  6BCEA59D5E7C7130 CRC64;
     MVVTQLNLEF CFQGKKLRGF SCELTRSPRG VLPESFFTIM CQVVVPILLS GLCMMTAGLV
     MNTVQHWPVF VEVKDLLTLV PPLVGLKGNL EMTLASRLST AANTGQIDDP QEQHRVISSN
     LALIQVQATV VGLLAAVAAL LLGVVSREEV DVAKVELLCA SSVLTAFLAA FALGVLMVCI
     VIGARKLGVN PDNIATPIAA SLGDLITLSI LALVSSFFYR HKDSRYLTPL VCLSFAALTP
     VWVLIAKQSP PIVKILKFGW FPIILAMVIS SFGGLILSKT VSKQQYKGMA IFTPVICGVG
     GNLVAIQTSR ISTYLHMWSA PGVLPLQMKK FWPNPCSTFC TSEINSMSAR VLLLLVVPGH
     LIFFYIIYLV EGQSVINSQT FLVLYLLAGL IQVTILLYLA EVMVRLTWHQ ALDPDNHCIP
     YLTGLGDLLG TGLLALCFFT DWLLKSKAEL GGISELASGP P
//
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