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Database: UniProt
Entry: A0A2I2YN41_GORGO
LinkDB: A0A2I2YN41_GORGO
Original site: A0A2I2YN41_GORGO 
ID   A0A2I2YN41_GORGO        Unreviewed;      4761 AA.
AC   A0A2I2YN41;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 5.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSGGOP00000036378};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000036378, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000036378, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000036378}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; CABD030009618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGGOT00000055014; ENSGGOP00000036378; ENSGGOG00000012582.
DR   GeneTree; ENSGT00940000154906; -.
DR   Proteomes; UP000001519; Chromosome 1.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4074   4093       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4294   4314       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4368   4387       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4504   4525       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4562   4583       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4638   4661       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      104    159       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      166    211       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      219    274       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      280    337       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      345    402       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      593    803       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1019   1217       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3817   3852       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      466    486       {ECO:0000256|SAM:Coils}.
FT   COILED     2873   2893       {ECO:0000256|SAM:Coils}.
FT   COILED     3138   3158       {ECO:0000256|SAM:Coils}.
FT   COILED     4206   4239       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4761 AA;  540941 MW;  BF4FE251BFEC83F9 CRC64;
     MIWTVQSCHV SLIFPSLSPP LQDDEVVLQC TATIHKEQQK LCLAAEGFGN RLCFLESTSN
     SKNVPPDLSI CTFVLEQSLS VRALQEMLAN TVEKSEGTAQ GGGHRTLLYG HAILLRHSYS
     GMYLCCLSTS RSSTDKLAFD VGLQEDTTGE ACWWTIHPAS KQRSEGEKVR VGDDLILVSV
     SSERYLHLSY GNGSLHVDAA FQQTLWSVAP ISSGSEAAQG YLIGGDVLRL LHGHMDECLT
     VPSGEHGEEQ RRTVHYEGGA VSVHARSLWR LETLRVAWSG SHIRWGQPFR LRHVTTGKYL
     SLMEDKNLLL MDKEKADVKS TAFTFRSSKE KLDVGVRKEV DGMGTSEIKY GDSVCYIQHV
     DTGLWLTYQS VDVKSVRMGS IQRKAIMHHE GHMDDGISLS RSQHEESRTA RVIRSTVFLF
     NRFIRGLDAL SKKAKASTVD LPIESVSLSL QDLIGYFHPP DEHLEHEDKQ NRLRALKNRQ
     NLFQEEGMIN LVLECIDRLH VYSSAAHFAD VAGREAGESW KSILNSLYEL LAALIRGNRK
     NCAQFSGSLD WLISRLERLE ASSGILEVLH CVLVESPEAL NIIKEGHIKS IISLLDKHGR
     NHKVLDVLCS LCVCHGVAVR SNQHLICDNL LPGRDLLLQT RLVNHVSSMR PNIFLGVSEG
     SAQYKKWYYE LMVDHTEPFV TAEATHLRVG WASTEGYSPY PGGGEEWGGN GVGDDLFSYG
     FDGLHLWSGC IARTVSSPNQ HLLRTDDVIS CCLDLSAPSI SFRINGQPVQ GMFENFNIDG
     LFFPVVSFSA GIKVRFLLGG RHGEFKFLPP PGYAPCYEAV LPKEKLKVEH SREYKQERTY
     TRDLLGPTVS LTQAAFTPIP VDTSQIVLPP HLERIREKLA ENIHELWVMN KIELGWQYGP
     VRDDNKRQHP CLVEFSKLPE QERNYNLQMS LETLKTLLAL GCHVGISDEH AEDKVKKMKL
     PKNYQLTSGY KPAPMDLSFI KLTPSQEAMV DKLAENAHNV WARDRIRQGW TYGIQQDVKN
     RRNPRLVPYT LLDDRTKKSN KDSLREAVRT LLGYGYNLEA PDQDHAARAE VCSGTGERFR
     IFRAEKTYAV KAGRWYFEFE TVTAGDMRVG WSRPGCQPDQ ELGSDERAFA FDGFKAQRWH
     QGNEHYGRSW QAGDVVGCMV DMNEHTMMFT LNGEILLDDS GSELAFKDFD VGDGKSTMFS
     TLMCLNSRRY HYSQLPKPNN VLQRFLFCLV LLCQYLVLLS SQYYYSVRIF PGQEPANVWV
     GWITSDFHQY DTGFDLDRVR TVTVTLGDEK GKVHESIKRS NCYMVCAGES MSPGQGRNNN
     GLEIGCVVDA ASGLLTFIAN GKELSTYYQV EPSTKLFPAV FAQATSPNVF QFELGRIKNV
     MPLSAGLFKS EHKNPVPQCP PRLHVQFLSH VLWSRMPNQF LKVDVSRISE RQGWLVQCLD
     PLQFMSLHIP EENRSVDILE LTEQEELLKF HYHTLRLYSA VCALGNHRVA HALCSHVDEP
     QLLYAIENKY MPGLLRAGYY DLLIDIHLSS YATARLMMNN EYIVPMTEET KSITLFPDEN
     KKHGLPGIGL STSLRPRMQF SSPSFVSISN ECYQYSPEFP LDILKSKTIQ MLTEAVKEGS
     LHARDPVGGT TEFLFVPLIK LFYTLLIMGI FHNEDLKHIL QLIEPSVFKE AATPEEESDT
     LEKELSVDDA KLQGAGEEEA KGGKRPKEGL LQMKLPEPVK LQMCLLLQYL CDCQVRHRIE
     AIVAFSDDFV AKLQDNQRFR YNEVMQALNM SAALTARKTK EFRSPPQEQI NMLLNFKDDK
     SECPCPEEIR DQLLDFHEDL MTHCGIELDE DGSLDGNSDL TIRGRLLSLV EKVTYLKKKQ
     AEKPVESDSK KSSTLQQLIS ETMVRWAQES VIEDPELVRA MFVLLHRQYD GIGGLVRALP
     KTYTINGVSV EDTINLLASL GQIRSLLSVR MGKEEEKLMI RGLGDIMNNK VFYQHPNLMR
     ALGMHETVME VMVNVLGGGE SKEITFPKMV ANCCRFLCYF CRISRQNQKA MFDHLSYLLE
     NSSVGLASPA MRGSTPLDVA AASVMDNNEL ALALREPDLE KVVRYLAGCG LQSCQMLVSK
     GYPDIGWNPV EGERYLDFLR FAVFCNGESV EENANVVVRL LIRRPECFGP ALRGEGGNGL
     LAAMEEAIKI AEDPSRDGPS PNSGSSKTLD TEEEEDDTIH MGNAIMTFYS ALIDLLGRCA
     PEMHLIHAGK GEAIRIRSIL RSLIPLGDLV GVISIAFQMP TIAKDGNVVE PDMSAGFCPD
     HKAAMVLFLD RVYGIEVQDF LLHLLEVGFL PDLRAAASLD TAALSATDMA LALNRYLCTA
     VLPLLTRCAP LFAGTEHHAS LIDSLLHTVY RLSKGCSLTK AQRDSIEVCL LSICGQLRPS
     MMQHLLRRLV FDVPLLNEHA KMPLKLLTNH YERCWKYYCL PGGWGNFGAA SEEELHLSRK
     LFWGIFDALS QKKYEQELFK LALPCLSAVA GALPPDYMES NYVSMMEKQS SMDSEGNFNP
     QPVDTSNITI PEKLEYFINK YAEHSHDKWS MDKLANGWIY GEIYSDSSKV QPLMKPYKLL
     SEKEKEIYRW PIKESLKTML AWGWRIERTR EGDSMALYNR TRRISQTSQV SVDAAHGYSP
     RAIDMSNVTL SRDLHAMAEM MAENYHNIWA KKKKMELESK GGGNHPLLVP YDTLTAKEKA
     KDREKAQDIL KFLQINGYAV SRGFKDLELD TPSIEKRFAY SFLQQLIRYV DEAHQYILEF
     DGGSRGKGEH FPYEQEIKFF AKVVLPLIDQ YFKNHRLYFL SAASRPLCSG GHASNKEKEM
     NIEKFSGQFI QHFVSSLGND ATSIVNCLHI LGQTLDARTV MKTGLESVKS ALRAFLDNAA
     EDLEKTMENL KQGQFTHTRN QPKGVTQIIN YTTVALLPML SSLFEHIGQH QFGEDLILED
     VQVSCYRILT SLYALGTSKS IYVERQRSAL GECLAAFAGA FPVAFLETHL DKHNIYSIYN
     TKSSRERAAL SLPTNVEDVC PNIPSLEKLM EEIVELAESG IRYTQMPHVM EVILPMLCSY
     MSRWWEHGPE NNPERAEMCC TALNSEHMNT LLGNILKIIY NNLGIDEGAW MKRLAVFSQP
     IINKVKPQLL KTHFLPLMEK LKKKAATVVS EEDHLKAEAR GDMSEAELLI LDEFTTLARD
     LYKYLYPFLI ILIYQINTYL CKNLQVLLVL TEISFATSQN FKREEQNFVV QNEINNMSFL
     ITDTKSKMSK AAVSDQERKK MKRKGDRYSM QTSLIVAALK RLLPIGLNIC APGDQELIAL
     AKNRFSLKDT EDEVRDIIRS NIHLQGKLED PAIRWQMALY KDLPNRTDDT SDPEKTVERV
     LDIANVLFHL EQKSKRVGRR HYCLGSTVEH PQRSKKAVWH KLLSKQRKRA VVACFRMAPL
     YNLPRHRAVN LFLQGYEKSW IETEEHYFED KLIEDLAKPG AEPPEEDEGT KRVDPLHQLI
     LLFSRTALTE KCCHDEEDDD GEEEVKSFEE KEMEKQKLLY QQARLHDRGA AEMVLQTISA
     SKGETGPMVA ATLKLGIAIL NGGNSTVQQK MLDYLKEKKD VGFFQSLAGL MQSCSVLDLN
     AFERQNKAEG LGMVTEEGSG EKVLQDDEFT CDLFRFLQLL CEGHNSDFQN YLRTQTGNNT
     TVNIIISTVD YLLRVQESIS DFYWYYSGKD VIDEQGQRNF SKAIQVAKQV FNTLTEYIQG
     PCTGNQQSLA HSRLWDAVVG FLHVFAHMQM KLSQDSSQIE LLKELMDLQK DMVVMLLSML
     EGNVVNGTIG KQMVDMLVES SNNVEMILKF FDMFLKLKDL TSSDTFKEYD PDGKGVISKR
     DFHKAMESHK HYTQSETEFL LSCAETDENE TLDYEEFVKR FHEPAKDIGF NVAVLLTNLS
     EHMPNDTRLQ TFLELAESVL NYFQPFLGRI EIMGSAKRIE RVYFEISESS RTQWEKPQVK
     ESKRQFIFDV VNEGGEKEKM ELFVNFCEDT IFEMQLAAQI SESDLNERSA NKEESEKERP
     EEQGPRMAFF SILTVKSALF ALRYNILTLM RMLSLKSLKK QMKKVKKMTV KDMVTAFFSS
     YWSIFMTLLH FVASVFRGFF RIICSLLLGG SLVEGAKKIK VAELLANMPD PTQDEVRGDG
     EEGERKPLEA ALPSEDLTDL KELTEESDLL SDIFGLDLKR EGGQYKLIPH NPNAGLSDLM
     SNPVPMPEVQ EKFQEQKAKE EEKEEKEETK SEPEKAEGED GEKEEKAKED KGKQKLRQLH
     THRYGEPEVP ESAFWKKIIA YQQKLLNYFA RNFYNMRMLA LFVAFAINFI LLFYKVSTSS
     VVEGKELPTR SSSENAKVTS LDSSSHRIIA VHYVLEESSG YMEPTLRILA ILHTVISFFC
     IIGYYCLKVP LVIFKREKEV ARKLEFDGLY ITEQPSEDDI KGQWDRLVIN TQSFPNNYWD
     KFVKRKVMDK YGEFYGRDRI SELLGMDKAA LDFSDAREKK KPKKDSSLSA VLNSIDVKYQ
     MWKLGVVFTD NSFLYLAWYM TMSVLGHYNN FFFAAHLLDI AMGFKTLRTI LSSVTHNGKQ
     LVLTVGLLAV VVYLYTVVAF NFFRKFYNKS EDGDTPDMKC DDMLTCYMFH MYVGVRAGGG
     IGDEIEDPAG DEYEIYRIIF DITFFFFVIV ILLAIIQGLI IDAFGELRDQ QEQVKEDMET
     KCFICGIGND YFDTVPHGFE THTLQEHNLA NYLFFLMYLI NKDETEHTGQ ESYVWKMYQE
     RCWEFFPAGD CFRKQYEDQL N
//
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