ID A0A2I2YP72_GORGO Unreviewed; 784 AA.
AC A0A2I2YP72;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Sodium channel epithelial 1 subunit delta {ECO:0000313|Ensembl:ENSGGOP00000036680.1};
GN Name=SCNN1D {ECO:0000313|Ensembl:ENSGGOP00000036680.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000036680.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000036680.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000036680.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000036680.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030000154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030000155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030000156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2YP72; -.
DR STRING; 9593.ENSGGOP00000036680; -.
DR Ensembl; ENSGGOT00000048257.1; ENSGGOP00000036680.1; ENSGGOG00000005342.3.
DR GeneTree; ENSGT00940000162685; -.
DR InParanoid; A0A2I2YP72; -.
DR OMA; RFHYVDI; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000005342; Expressed in prefrontal cortex and 4 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034706; C:sodium channel complex; IBA:GO_Central.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IBA:GO_Central.
DR GO; GO:0071468; P:cellular response to acidic pH; IEA:Ensembl.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IEA:Ensembl.
DR GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF132; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT DELTA; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022461}.
FT REGION 119..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..187
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 85974 MW; A8B6DC5A072087F0 CRC64;
MPVLSQKTTP LPRYLWPGHL SGPRRLTWSW CSDHRTPTCQ ELARGWPRRG GGPCGFTSAG
HVLCGHPLCL LSGPIQGCGT GLGDSSIASL SRTSRVAAAS FQSRPRSFWL ALAPPQSTSE
QAWAAGQPHA GRMDTLPSPG PVAPQRPCHL EGWQHRPTQH NPACRQGQAA AQTPPRPGPP
SAAPPPPKEG HQEGLVELPA SFRELLTFFC TNATIHGAIR LVCSRGNRLK TTSWGLLSLG
ALVALCWQLG LLFQRHWHRP VLMAVSVHSE RKLLPLVTLC DGNPRRPSPV LRHLELLDEF
ARENIDSLYN VNLSKGRAAL SATVPRHEPP FHLDREIRLQ RLSHSGSRVR VGFRLCNSTG
GDCFYRSYTS GVVAVQDWYH FHYVDILALL PAAWEDSHGS QDGHFVLSCS YDGLDCQARQ
FRTFHHPTYG SCYTVDGVWT AQRPGITHGV GLVLRVEQQP HLPLLSTLAG IRVMVHGRNH
TPFLGHHSFS VRPGTEATIS IREDEVHRLG SPYGHCTTGG EGVEVELLHN TSYTRQACLV
SCFQQLMVET CSCGYYLHPL PAGAEYCSSA QHPAWGHCFY RLYQDLETHR LPCTSRCPRP
CRESAFKLST GTSRWPSAKS AGWTLATLGE QGLPRQSHRQ RSNLAKINIV YQELNYHSVE
EAPVYSVPQL LSAMGSLCSL WFGASVLSLL ELLELLLDAS ALTLVLSGHR LCRAWFSWPR
ASPASGASNI KPEASQMPTP AGGTSDDPEP SGPHLPRVML PGVLAGVSAE ESWAGPRPLE
TLDT
//
