ID A0A2I2YPN6_GORGO Unreviewed; 385 AA.
AC A0A2I2YPN6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Protein arginine methyltransferase 8 {ECO:0000313|Ensembl:ENSGGOP00000036943.1};
GN Name=PRMT8 {ECO:0000313|Ensembl:ENSGGOP00000036943.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000036943.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000036943.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000036943.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000036943.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030082436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030082437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030082438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030082439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030082440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030082441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030082442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2YPN6; -.
DR SMR; A0A2I2YPN6; -.
DR Ensembl; ENSGGOT00000045277.1; ENSGGOP00000036943.1; ENSGGOG00000010268.4.
DR GeneTree; ENSGT00940000155867; -.
DR Proteomes; UP000001519; Chromosome 12.
DR Bgee; ENSGGOG00000010268; Expressed in prefrontal cortex and 2 other cell types or tissues.
DR GO; GO:0016274; F:protein-arginine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11006:SF47; PROTEIN ARGININE N-METHYLTRANSFERASE 8; 1.
DR Pfam; PF06325; PrmA; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51678; SAM_MT_PRMT; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01015};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01015};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU01015}.
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 385 AA; 44169 MW; 20E4A89EFD1C520D CRC64;
MESLASDGFK LKEVSSVNSP PSQPPQPVVP AKPVQCVHHV STQPSCPGRG KMSKLLNPEE
MTSRDYYFDS YAHFGIHEEM LKDEVRTLTY RNSMYHNKHV FKDKVVLDVG SGTGILSMFA
AKAGAKKVFG IECSSISDYS EKIIKANHLD NIITIFKGKV EEVELPVEKV DIIISEWMGY
CLFYESMLNT VIFARDKWLK PGGLMFPDRA ALYVVAIEDR QYKDFKIHWW ENVYGFDMTC
IRDVAMKEPL VDIVDPKQVV TNACLIKEVD IYTVKTEELS FTSAFCLQIQ RNDYVHALVT
YFNIEFTKCH KKMGFSTAPD APYTHWKQTV FYLEDYLTVR RGEEIYGTIS MKPNAKNVRD
LDFTVDLDFK GQLCETSVSN DYKMR
//
