ID A0A2I2YR06_GORGO Unreviewed; 1104 AA.
AC A0A2I2YR06;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Par-3 family cell polarity regulator beta {ECO:0000313|Ensembl:ENSGGOP00000037375.1};
GN Name=PARD3B {ECO:0000313|Ensembl:ENSGGOP00000037375.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000037375.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000037375.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000037375.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000037375.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
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DR EMBL; CABD030018186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030018187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030018188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030018189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030018190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030018191; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030018192; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030018193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030018194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030018195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2YR06; -.
DR Ensembl; ENSGGOT00000045824.1; ENSGGOP00000037375.1; ENSGGOG00000034911.2.
DR GeneTree; ENSGT00950000183214; -.
DR Proteomes; UP000001519; Chromosome 2B.
DR Bgee; ENSGGOG00000034911; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 2.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF4; PARTITIONING DEFECTIVE 3 HOMOLOG B; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 2.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 201..289
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 383..456
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 498..573
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 82..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..851
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..926
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1066
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1087..1104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1104 AA; 121258 MW; EAB616E352EB3D1C CRC64;
MKVTVCFGRT GIVVPCKEGQ LRVGELTQQA LQRYLKTREK GPGYWVKIHH LEYTDGGILD
PDDVLADVVE DKDKLIAVFE EQEPLHKIES PSGNPADRQS PDAFETEVAA QLAAFKPIGG
EIEVTPSALK LGTPLLVRRS SDPVPGPPAD TQPSASHPGG QSLKPVVPDS TQNLEDREVL
NGVQTELLTS PKTKDTLSDM TRTVEISGEG GPLGIHVVPF FSSLSGRILG LFIRGIEENS
RSKREGLFHE NECIVKINNV DLVDKTFAQA QDVFRQAMKS ASVLLHVLPP QNREQYEKSV
IGSLNIFGNN DGVLKTKVPP PVHGKSGLKT ANLTGTDSPE TDASASLQQN KSPRVPRLGG
KPSSPSLSPL MGFGSKKNAK KIKIDLKKGP EGLGFTVVTR DSSIHGPGPI FVKNILPKGA
AIKDGRLQSG DRILEVNGRD VTGRTQEELV AMLRSTKQGE IASLVIARQE GHFLPRELKG
EPDCCALSLE TSEQLTFEIP LNDSGSAGLG VSLKGNKSRE TGTDLGIFIK SIIHGGAAFK
DGRLRMNDQL IAVNGESLLG KSNHEAMETL RRSMSMEGNI RGMIQLVILR RPERPMEDPA
ECGAFSKPCF ENSQNAVTTS RRNDNSILHA LGTYSPQDKQ KDLLLPNDGW AESEVPPSPT
PHSALELGLE DYSHSSGVDS AVYFPDQHIN FRSVTPARQP ESINLKASKS MDLVPDESKV
HSLAGQKSES PSKDFGPTLG LKKSSSLESL QTAVAEVRKN DLPFHRPRPH MVRGRGCNES
FRAAIDKSYD GPEEIEADGL SDKSSHSGQG ALNCESAPQG NSELEDMENK ARKVKKTKEK
EKKKEKGKLK VKEKKRKEEN EDPERKIKKK GFGAMLRFGK KKEDKGGKAE QKGTLKHGGL
REEELEKMKE ERESGRPTGG STDRIQKLRK EYYQARREGF PLYEDDEGRA RPSEYDLLWV
PGKGPDGNAH NLRFEGMERQ YASLPRGGPA DPVDYLPAAP RGLYKERELP YYPGAHPMHP
PKGSYPRPTE LRVADLRYPQ HYPPPPAPQH KGPFRQDVPP SPPQHQRMPA YQETGRPGPR
GGSPDQYPYR TQDSRQKNPM TAAV
//
