ID A0A2I2YTB8_GORGO Unreviewed; 2548 AA.
AC A0A2I2YTB8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Collagen type VI alpha 3 chain {ECO:0000313|Ensembl:ENSGGOP00000038220.1};
GN Name=COL6A3 {ECO:0000313|Ensembl:ENSGGOP00000038220.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000038220.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000038220.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000038220.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000038220.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030019316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000053934.1; ENSGGOP00000038220.1; ENSGGOG00000002468.3.
DR GeneTree; ENSGT00940000156462; -.
DR Proteomes; UP000001519; Chromosome 2B.
DR Bgee; ENSGGOG00000002468; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProt.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR CDD; cd22629; Kunitz_collagen_alpha3_VI; 1.
DR CDD; cd01481; vWA_collagen_alpha3-VI-like; 3.
DR CDD; cd01450; vWFA_subfamily_ECM; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 9.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR041900; vWA_collagen_alpha3-VI-like.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF13; COLLAGEN ALPHA-3(VI) CHAIN; 1.
DR Pfam; PF01391; Collagen; 4.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF00092; VWA; 9.
DR PRINTS; PR00759; BASICPTASE.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00131; KU; 1.
DR SMART; SM00327; VWA; 9.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF53300; vWA-like; 9.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50234; VWFA; 9.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..208
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 225..397
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 417..593
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 621..792
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 824..997
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1027..1200
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1226..1412
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1772..1951
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1989..2185
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2362..2456
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2483..2533
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT REGION 1000..1022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1429..1747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2229..2258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2328..2357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2444..2464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1496..1512
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1520..1540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1665..1687
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2548 AA; 275968 MW; 7729902CC6CC2EA7 CRC64;
TGVCPHARLI FVFLVVMGFP LVGQAVIEVN KRDIVFLVDG SSALGLANFN AIRDFIAKVI
QRLEIGQDLI QVAVAQYADT VRPEFYFNTH PTKREVITAV RKMKPLDGSA LYTGSALDFV
RNNLFTSSAG YRAAEGIPKL LVLITGGKSL DEISQPAQEL KRSSIMAFAI GNKGADQAEL
EEIAFDSSLV FIPAEFRAAP LQGMLPGLLA PLRTLSGTPE ESKRDILFLF DGSANLVGQF
PVVRDFLYKI IDELDVKPDG TRIAVAQYSD DVKVESRFDE HQSKPEILNL VKRMKIKTGK
ALNLGYALDY AQRYIFVKSA GSRIEDGVLQ FLVLLVAGRS SDRVDGPASN LKQSGVVPFI
FQAKNADPAE LEQIVLSPAF ILAAESLPKI GDLQPQIVNL LKSVHNGAPA PVSGEKDVVF
LLDGSEGVRS GFPLLKEFVQ RVVESLDVGQ DRVRVAVVQY SDRTRPEFYL NSYMNQQDVV
NAVRQLTLLG GPTPNTGAAL EFVLRNILVS SAGSRITEGV PQLLIVLTAD RSGDDVRNPS
VVVKRGGAVP IGIGIGNADI TEMQTISFIP DFAVAIPTFR QLGTVQQVIS ERVTQLTRKE
LSRLQPVLQP LPSPGVGGKR DVVFLIDGSQ SAGPEFQYIR TLIERLVDYL DVGFDTTRVA
VIQFSDDPKV EFLLNAHSSK DEVQNAVQRL RPKGGRQINV GSALEYVSRN IFKRPLGSRI
EEGVPQFLVL ILSGKSDDEV DDPAVELKQF GVAPFTIARN ADQEELVKIS LSPEYVFSVS
TFRELPSLEQ KLLTPITTLT SEQIQKLLAS TRYPPPAVES DAADIVFLID SSEGVRPDGF
AHIRDFVSRI VRRLNIGPSK VRVGVVQFSN DVFPEFYLKT YRSQAPVLDA IRRLRLRGGS
PLNTGKALEF VARNLFVKSA GSRIEDGVPQ HLVLVLGGKS QDDVSRFAQV IRSSGIVSLG
VGDRNIDRTE LQTITNDPRL VFTVREFREL PNIEERIMNS FGPSAATPAP PGVDTPPPSR
PEKKKADIVF LLDGSINFRR DSFQEVLRFV SEIVDTVYED GDSIQVGLVQ YNSDPTDEFF
LKDFSTKRQI IDAINKVVYK GGRHANTKVG LEHLRVNHFV PEAGSRLDQR VPQIAFVITG
GKSVEDAQDV SLALTQRGVK VFAVGVRNID SEEVGKIASN SATAFRVGNV QELSELSEQV
LETLHDAMHE TLCPGVTDAA KACNLDVILG FDGSRDQNVF VAQKGFESKV DAILNRISQM
HRVSCSGGRS PTVRVSVVAN TPSGPVEAFD FDEYQPEMLE KFRNMRSQHP YVLTEDTLKV
YLNKFRQSSP DSVKVVIHFT DGADGDLADL HRASENLRQE GVRALILVGL ERVANLERLM
HVEFGRGFMY DRPLRLNLLD LDYELAEQLD NIAEKACCGV PCKCSGQRGD RGPIGSIGPK
GIPGEDGYRG YPGDEGGPGE RGPPGVNGTQ GFQGCPGQRG VKGSRGFPGE KGEVGEIGLD
GLDGEDGDKG LPGSSGEKGN PGRRGDKGPR GEKGERGDVG IRGDPGNPGQ DSQERGPKGE
TGDLGPMGVP GRDGVPGGPG ETGKNGGFGR RGPPGAKGNK GGPGQPGFEG EQGTRGAQGP
AGPAGPPGLI GEQGISGPRV SLGHIAKQAE KPGPKGGIGN RGPRGETGDD GRDGVGSEGR
RGKKGERGFP GYPGPKGNPG EPGLNGTTGP KGIRGRRGNS GPPGIVGQKG DPGYPGPAGP
KGNRGDSIDQ CALIQSIKDK CRPLECPVFP TELAFALDTS EGVNQDTFGR MRDVVLSIVN
DLTIAESNCP RGARVAVVTY NNEVTTEIRF ADSKRKSVLL DKIKNLQVAL TSKQQSLETA
MSFVARNTFK RVRNGFLMRK VAVFFSNTPT RASPQLREAV LKLSDAGITP LFLTRQEDRQ
LINALQINNT AVGHALVLPA GRDLTDFLEN VLTCHVCLDI CNIDPSCGFG SWRPSFRDRR
AAGSDVDIDM AFILDSAETT TLFQFNEMKK YVAYLVRQLD MSPDPKASQH FARVAVVQHA
PSESVDNASM PPVKVEFSLT DYGSKEKLVD FLSRGMTQLQ GTRALGSAIE YTIENVFESA
PNPRDLKIVV LMLTGEVPEQ QLEEAQRVIL QAKCKGYFFV VLGIGRKVNI KEVYTFASEP
NDVFFKLVDK STELNEEPLM RFGRLLPSFV SSENAFYLSP DIRKQCDWFQ GDQPTKNLVK
FGHKQVNVPN NVTSSPTSNP VTTTKPVTTT KPVTTTTKPV TTTTKPVIIV NQASVKPPAP
VKPAPAKPVA AKPVATKTAT VRPPVAVKPA TAAKPVAAKP AAVRPPAAAA AKPVATKPEV
PRPQAAKPAA TKPATTKPVV KMSREVQVFE ITENSAKLHW ERPEPPGPYF YDLTVTSAHD
QSLVLKQNLT VTDRVIGGLL AGQTYHVAVV CYLRSQVRAT YHGSFSTKKS QPPPPQPARS
ASSSTINLMV STEPLALTET DICKLPKDEG TCRDFILKWY YDPNTKSCAR FWYGGCGGNE
NKFGSQKECE KVCAPVLAKP GVISVMGT
//
