ID A0A2I2YW14_GORGO Unreviewed; 943 AA.
AC A0A2I2YW14;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Inter-alpha-trypsin inhibitor heavy chain 2 {ECO:0000313|Ensembl:ENSGGOP00000039058.1};
GN Name=ITIH2 {ECO:0000313|Ensembl:ENSGGOP00000039058.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000039058.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000039058.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000039058.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000039058.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the ITIH family.
CC {ECO:0000256|ARBA:ARBA00010158}.
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DR EMBL; CABD030067851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030067852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030067853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030067854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030067855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2YW14; -.
DR Ensembl; ENSGGOT00000062636.1; ENSGGOP00000039058.1; ENSGGOG00000011977.4.
DR GeneTree; ENSGT00940000157945; -.
DR Proteomes; UP000001519; Chromosome 10.
DR Bgee; ENSGGOG00000011977; Expressed in liver and 4 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF14; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2; 1.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..943
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014115753"
FT DOMAIN 53..182
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 307..490
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 943 AA; 105838 MW; 75D39A97830EFD99 CRC64;
MKRLTCFFIC FFLSEVSGFE IPINGLSEVS TSRSLLAVGL FMSSVNRLLE SSLPGESEEM
MEEVDQVTLY SYKVQSTITS RMATTMIQSK VVNNSPQPQN VVFDVQIPKG AFISNFSMTV
DGKTFRSSIK EKTVGRALYA QARAKGKTAG LVRSSALDME NFRTEVNVLP GAKVQFELHY
QEVKWRKLGS YEHRIYLQPG RLAKHLEVDV WVIEPQGLRF LHVPDTFEGH FDSVPVISKG
QQKAHVSFKP TVAQQRICPS CRETAVDGEL VVLYDVKREE KAGELEVFNG YFVHFFAPDN
LDPIPKNILF VIDVSGSMWG VKMKQTVEAM KTILDDLRAE DHFSVIDFNQ NIRTWRNDLI
SATKTQVADA KRYIEKIQPS GGTNINEALL RAIFILNEAR NLGLLDPNSV SLIILVSDGD
PTVGELKLSK IQKNVKENIQ DNISLFSLGM GFDVDYDFLK RLSNENHGIA QRIYGNQDTS
SQLKKFYNQV STPLLRNVQF NYPHTSVTDV TQNNFHNYFG GSEIVVAGKF DPAKLDQIES
VITATSANTQ LVLETLAQMD DLQDFLSKDK HADPDFTRKL WAYLTINQLL AERSLAPTAA
AKRRITRSIL QMSLDHHIVT PLTSLVIENE AGDERMLADA PLQDPSCCSG ALYYGSKVVP
DSTPSWANPS PTPVISMLAQ GSQVLESTPP PHVMRVENDP HFIIYLPKSQ KNICFNIDSE
PGKILNLVSD PESGIVVNGQ LVGAKKPNNG KLSTYFGKLG FYFQSEDIKI EISTETITLS
HGSSTFALSW SDTAQVMNQR VQISVKKEKV VTITLNKEMS FSVLLHRVWK KHPVNVDFLG
IYIPSTNKFS PKAHGLIGQF MQEPKIHIFN ERPGKDPEKP EASMEVKGQK LIITRGLQKD
YRTDLVFGTD VTCWFVHNSG KGFIDGHYKD YFVPQLYSFL KRP
//
