ID A0A2I2YW28_GORGO Unreviewed; 2016 AA.
AC A0A2I2YW28;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Dedicator of cytokinesis 6 {ECO:0000313|Ensembl:ENSGGOP00000039073.1};
GN Name=DOCK6 {ECO:0000313|Ensembl:ENSGGOP00000039073.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000039073.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000039073.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000039073.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000039073.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; CABD030111626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030111627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030111628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030111629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030111630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030111631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030111632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000046571.1; ENSGGOP00000039073.1; ENSGGOG00000009524.3.
DR GeneTree; ENSGT00940000159313; -.
DR Proteomes; UP000001519; Chromosome 19.
DR Bgee; ENSGGOG00000009524; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF65; DEDICATOR OF CYTOKINESIS PROTEIN 6; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 548..714
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1559..1992
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 22..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1994..2016
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1062
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2016 AA; 226127 MW; 103DFE60813F639B CRC64;
AAAAEQLGPG HSFVPTVAAE VRKQVSRERS GSPHSSRRCS SSLGVPLTEV VEPLDFEDIL
LSRPPDAEPG PLRDLVEFPA DDLELLLQPR ECRTTEAGIP KDEKLDAQVR AAVEMYIEDW
VTVHRRYQYL SAAYSPVTTE TQRERQKGLP RQVFEQDASG DERSGPEDSN DSRRGSGSPE
DTPRSSGASS IFDLKNLAAD SLLPSLLERA APEDVDRRNE ALRRQHRPPA LLTLYPAPDE
DEAVERCSRP EPPREHFGQR ILVKCLSLKF EIEIEPIFGI LALYDVREKK KISENFYFDL
NSDSMKGLLR AHGTHPAIST LARSAIFSVT YPSPDIFLVI KLEKVLQQGD ISECCEPYMV
LKEVDTAKNK EKLEKLRLAA EQFCTRLGRY RMPFAWTAVH LANIVSSAGQ LDRDSDSEGE
RRPAWTDRRR RGPQDRASSG DDACSFSGFR PATLTVTNFF KQEAERLSDE DLFKFLADMR
RPSSLLRRLR PVTAQLKIDI SPAPENPHFC LSPELLHIKP YPDPRGRPTK EILEFPAREV
YAPHTSYRNL LYVYPHSLNF SSRQGSVRNL AVRVQYMTGE DPSQALPVIF GKSSCSEFTR
EAFTPVVYHN KSPEFYEEFK LHLPACVTEN HHLLFTFYHV SCQPRPGTAL ETPVGFTWIP
LLQHGRLRTG PFCLPVSVDQ PPPSYSVLTP DVALPGMRWV DGHKGVFSVE LTAVSSVHPQ
DPYLDKFFTL VHVLEEGAFP FRLKDTVLSE GNVEQELRAS LAALRLASPE PLVAFSHHVL
DKLVRLVIRP PIISGQIVNL GRGAFEAMAH VVSLVHRSLE AAQDARGHCP QLAAYVHYAF
RLPGTEPSLP DGDAPPPSRV QGGLGWHLAL CDPCLCPQLL HEELALQWVV SSSAVREAIL
QHAWFFFQLM VKSMALHLLL GQRLDTPRKL RFPGRFLDDI TALVGSVGLE VITRVHKDVE
LAEHLNASLA FFLSDLLSLV DRGFVFSLVR AHYKQVATRL QSSPNPAALL TLRMEFTRIL
CSHEHYVTLN LPCCPLSPPA SPSPSVSSTT SQSSTFSSQA PDPKVTSMFE LSGPFRQQHF
LAGLLLTELA LALEPEAEGA FLLHKKAISA VHSLLCGHDT DPRYAEATVK ARVAELYLPL
LSIARDTLPR LHDFAEGPGQ RSRLASMLDS DTEGEGDIAG TINPSVAMAI AGGPLAPGSR
ASISQGPPTA SRAGCALSAE SSRTLLACVL WVLKNAEPAL LQHWATDLTL PQLGRLLDLL
YLCLAAFEYK GKKAFERINS LTFKKSLDMK ARLEEAILGT IGARQEMVRR SRERSPFGNP
ENVRWRKSVT HWKQTSDRVD KTKDEMEHEA LVEGNLATEA SLVVLDTLEI IVQTVMLSEA
RESVLGAVLK VVLYSLGSAQ SALFLQHGLA TQRALVSKFP ELLFEEDTEL CADLCLRLLR
HCGSRISTIR THASASLYLL MRQNFEIGHN FARVKMQVTM SLSSLVGTTQ NFSEEHLRRS
LKTILTYAEE DMGLRDSTFA EQVQDLMFNL HMILTDTVKM KEHQEDPEML IDLMYRIARG
YQGSPDLRLT WLQNMAGKHA ELGNHAEAAQ CMVHAAALVA EYLALLEDHR HLPVGCVSFQ
NISSNVLEES AISDDILSPD EEGFCSGKHF TELGLVGLLE QAAGYFTMGG LYEAVNEVYK
NLIPILEAHR DYKKLAAVHG KLQEAFTKIM HQPQRVFGTY FRVGFYGARF GDLDEQEFVY
KEPSITKLAE ISHRLEEFYT ERFGDDVVEI IKDSNPVDKS KLDSQKAYIQ ITYVEPYFDT
YELKDRVTYF DRNYGLRTFL FCTPFTPDGR AHGELPEQHK RKTLLSTDHA FPYIKTRIRV
CHREETVLTP VEVAIEDMQK KTRELAFATE QDPPDAKMLQ MVLQGSVGPT VNQGPLEVAQ
VFLAEIPEDP KLFRHHNKLR LCFKDFCKKC EDALRKNKAL IGPDQKEYHR ELERNYCRLR
EALQPLLTQR LPQLMAPTPP GLRNSLNRAS FRKADL
//
