GenomeNet

Database: UniProt
Entry: A0A2I2YY54_GORGO
LinkDB: A0A2I2YY54_GORGO
Original site: A0A2I2YY54_GORGO 
ID   A0A2I2YY54_GORGO        Unreviewed;      4746 AA.
AC   A0A2I2YY54;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 5.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSGGOP00000039784};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000039784, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000039784, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000039784}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CABD030009618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGGOT00000065189; ENSGGOP00000039784; ENSGGOG00000012582.
DR   GeneTree; ENSGT00940000154906; -.
DR   Proteomes; UP000001519; Chromosome 1.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4066   4085       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4279   4299       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4353   4372       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4489   4510       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4547   4568       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4623   4646       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      111    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    218       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      226    281       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      287    344       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      352    409       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      600    810       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1026   1229       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3809   3844       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      473    493       {ECO:0000256|SAM:Coils}.
FT   COILED     2870   2890       {ECO:0000256|SAM:Coils}.
FT   COILED     3135   3155       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4746 AA;  539246 MW;  3E4A1BD4D4C6CB59 CRC64;
     MIWTVQSCHV SLIFPSLSPP LQDDEVVLQC TATIHKEQQK LCLAAEGFGN RLCFLESTSN
     SKNVPPDLSI CTFVLEQSLS VRALQEMLAN TVEKSEGQVD VEKWTAQGGG HRTLLYGHAI
     LLRHSYSGMY LCCLSTSRSS TDKLAFDVGL QEDTTGEACW WTIHPASKQR SEGEKVRVGD
     DLILVSVSSE RYLHLSYGNG SLHVDAAFQQ TLWSVAPISS GSEAAQGYLI GGDVLRLLHG
     HMDECLTVPS GEHGEEQRRT VHYEGGAVSV HARSLWRLET LRVAWSGSHI RWGQPFRLRH
     VTTGKYLSLM EDKNLLLMDK EKADVKSTAF TFRSSKEKLD VGVRKEVDGM GTSEIKYGDS
     VCYIQHVDTG LWLTYQSVDV KSVRMGSIQR KAIMHHEGHM DDGISLSRSQ HEESRTARVI
     RSTVFLFNRF IRGLDALSKK AKASTVDLPI ESVSLSLQDL IGYFHPPDEH LEHEDKQNRL
     RALKNRQNLF QEEGMINLVL ECIDRLHVYS SAAHFADVAG REAGESWKSI LNSLYELLAA
     LIRGNRKNCA QFSGSLDWLI SRLERLEASS GILEVLHCVL VESPEALNII KEGHIKSIIS
     LLDKHGRNHK VLDVLCSLCV CHGVAVRSNQ HLICDNLLPG RDLLLQTRLV NHVSSMRPNI
     FLGVSEGSAQ YKKWYYELMV DHTEPFVTAE ATHLRVGWAS TEGYSPYPGG GEEWGGNGVG
     DDLFSYGFDG LHLWSGCIAR TVSSPNQHLL RTDDVISCCL DLSAPSISFR INGQPVQGMF
     ENFNIDGLFF PVVSFSAGIK VRFLLGGRHG EFKFLPPPGY APCYEAVLPK EKLKVEHSRE
     YKQERTYTRD LLGPTVSLTQ AAFTPIPVDT SQIVLPPHLE RIREKLAENI HELWVMNKIE
     LGWQYGPVRD DNKRQHPCLV EFSKLPEQER NYNLQMSLET LKTLLALGCH VGISDEHAED
     KVKKMKLPKN YQLTSGYKPA PMDLSFIKLT PSQEAMVDKL AENAHNVWAR DRIRQGWTYG
     IQQDVKNRRN PRLVPYTLLD DRTKKSNKDS LREAVRTLLG YGYNLEAPDQ DHAARAEVCS
     GTGERFRIFR AEKTYAVKAG RWYFEFETVT AGDMRVGWSR PGCQPDQELG SDERAFAFDG
     FKAQRWHQGN EHYGRSWQAG DVVGCMVDMN EHTMMFTLNG EILLDDSGSE LAFKDFDVGD
     GKSTMFCVFF KFATQLGLQI QVLFCLVLLC QYLVLLSSQY YYSVRIFPGQ EPANVWVGWI
     TSDFHQYDTG FDLDRVRTVT VTLGDEKGKV HESIKRSNCY MVCAGESMSP GQGRNNNGLE
     IGCVVDAASG LLTFIANGKE LSTYYQVEPS TKLFPAVFAQ ATSPNVFQFE LGRIKNVMPL
     SAGLFKSEHK NPVPQCPPRL HVQFLSHVLW SRMPNQFLKV DVSRISERQG WLVQCLDPLQ
     FMSLHIPEEN RSVDILELTE QEELLKFHYH TLRLYSAVCA LGNHRVAHAL CSHVDEPQLL
     YAIENKYMPG LLRAGYYDLL IDIHLSSYAT ARLMMNNEYI VPMTEETKSI TLFPDENKKH
     GLPGIGLSTS LRPRMQFSSP SFVSISNECY QYSPEFPLDI LKSKTIQMLT EAVKEGSLHA
     RDPVGGTTEF LFVPLIKLFY TLLIMGIFHN EDLKHILQLI EPSVFKEAAT PEEESDTLEK
     ELSVDDAKLQ GAGEEEAKGG KRPKEGLLQM KLPEPVKLQM CLLLQYLCDC QVRHRIEAIV
     AFSDDFVAKL QDNQRFRYNE VMQALNMSAA LTARKTKEFR SPPQEQINML LNFKDDKSEC
     PCPEEIRDQL LDFHEDLMTH CGIELDEDGS LDGNSDLTIR GRLLSLVEKV TYLKKKQAEK
     PVESDSKKSS TLQQLISETM VRWAQESVIE DPELVRAMFV LLHRQYDGIG GLVRALPKTY
     TINGVSVEDT INLLASLGQI RSLLSVRMGK EEEKLMIRGL GDIMNNKVFY QHPNLMRALG
     MHETVMEVMV NVLGGGESKE ITFPKMVANC CRFLCYFCRI SRQNQKAMFD HLSYLLENSS
     VGLASPAMRG STPLDVAAAS VMDNNELALA LREPDLEKVV RYLAGCGLQS CQMLVSKGYP
     DIGWNPVEGE RYLDFLRFAV FCNGESVEEN ANVVVRLLIR RPECFGPALR GEGGNGLLAA
     MEEAIKIAED PSRDGPSPNS GSSKTLDTEE EEDDTIHMGN AIMTFYSALI DLLGRCAPEM
     HLIHAGKGEA IRIRSILRSL IPLGDLVGVI SIAFQMPTIA KDGNVVEPDM SAGFCPDHKA
     AMVLFLDRVY GIEVQDFLLH LLEVGFLPDL RAAASLDTAA LSATDMALAL NRYLCTAVLP
     LLTRCAPLFA GTEHHASLID SLLHTVYRLS KGCSLTKAQR DSIEVCLLSI CGQLRPSMMQ
     HLLRRLVFDV PLLNEHAKMP LKLLTNHYER CWKYYCLPGG WGNFGAASEE ELHLSRKLFW
     GIFDALSQKK YEQELFKLAL PCLSAVAGAL PPDYMESNYV SMMEKQSSMD SEGNFNPQPV
     DTSNITIPEK LEYFINKYAE HSHDKWSMDK LANGWIYGEI YSDSSKVQPL MKPYKLLSEK
     EKEIYRWPIK ESLKTMLAWG WRIERTREGD SMALYNRTRR ISQTSQVSVD AAHGYSPRAI
     DMSNVTLSRD LHAMAEMMAE NYHNIWAKKK KMELESKGGG NHPLLVPYDT LTAKEKAKDR
     EKAQDILKFL QINGYAVSRG FKDLELDTPS IEKRFAYSFL QQLIRYVDEA HQYILEFDGG
     SRGKGEHFPY EQEIKFFAKV VLPLIDQYFK NHRLYFLSAA SRPLCSGGHA SNKEKEMNIE
     KFSGQFIQHF VSSLGNDATS IVNCLHILGQ TLDARTVMKT GLESVKSALR AFLDNAAEDL
     EKTMENLKQG QFTHTRNQPK GVTQIINYTT VALLPMLSSL FEHIGQHQFG EDLILEDVQV
     SCYRILTSLY ALGTSKSIYV ERQRSALGEC LAAFAGAFPV AFLETHLDKH NIYSIYNTKS
     SRERAALSLP TNVEDVCPNI PSLEKLMEEI VELAESGIRY TQMPHVMEVI LPMLCSYMSR
     WWEHGPENNP ERAEMCCTAL NSEHMNTLLG NILKIIYNNL GIDEGAWMKR LAVFSQPIIN
     KVKPQLLKTH FLPLMEKLKK KAATVVSEED HLKAEARGDM SEAELLILDE FTTLKYLYPF
     LIILIYQINT YLCKNLQVLL VLTEISFATS QNFKREEQNF VVQNEINNMS FLITDTKSKM
     SKAAVSDQER KKMKRKGDRY SMQTSLIVAA LKRLLPIGLN ICAPGDQELI ALAKNRFSLK
     DTEDEVRDII RSNIHLQGKL EDPAIRWQMA LYKDLPNRTD DTSDPEKTVE RVLDIANVLF
     HLEQKSKRVG RRHYCLGSTV EHPQRSKKAV WHKLLSKQRK RAVVACFRMA PLYNLPRHRA
     VNLFLQGYEK SWIETEEHYF EDKLIEDLAK PGAEPPEEDE GTKRVDPLHQ LILLFSRTAL
     TEKCCHDEED DDGEEEVKSF EEKEMEKQKL LYQQARLHDR GAAEMVLQTI SASKGETGPM
     VAATLKLGIA ILNGGNSTVQ QKMLDYLKEK KDVGFFQSLA GLMQSCSVLD LNAFERQNKA
     EGLGMVTEEG SGEKVLQDDE FTCDLFRFLQ LLCEGHNSDF QNYLRTQTGN NTTVNIIIST
     VDYLLRVQES ISDFYWYYSG KDVIDEQGQR NFSKAIQVAK QVFNTLTEYI QGPCTGNQQS
     LAHSRLWDAV VGFLHVFAHM QMKLSQDSSQ IELLKELMDL QKDMVVMLLS MLEGNVVNGT
     IGKQMVDMLV ESSNNVEMIL KFFDMFLKLK DLTSSDTFKE YDPDGKGVIS KRDFHKAMES
     HKHYTQSETE FLLSCAETDE NETLDYEEFV KRFHEPAKDI GFNVAVLLTN LSEHMPNDTR
     LQTFLELAES VLNYFQPFLG RIEIMGSAKR IERVYFEISE SSRTQWEKPQ VKESKRQFIF
     DVVNEGGEKE KMELFVNFCE DTIFEMQLAA QISESDLNER SANKEESEKE RPEEQGPRMA
     FFSILTVKSA LFALRYNILT LMRMLSLKSL KKQMKKVKKM TVKDMVTAFF SSYWSIFMTL
     LHFVASVFRG FFRIICSLLL GGSLVEGAKK IKVAELLANM PDPTQDEVRG DGEEGERKPL
     EAALPSEDLT DLKELTEESD LLSDIFGLDL KREGGQYKLI PHNPNAGLSD LMSNPVPMPE
     VQEKFQFFSF WRAYVLFVCF HRGEDGEKEE KAKEDKGKQK LRQLHTHRYG EPEVPESAFW
     KKIIAYQQKL LNYFARNFYN MRMLALFVAF AINFILLFYK VSTSSVVEGK ELPTRSSSEN
     AKVTSLDSSS HRIIAVHYVL EESSGYMEPT LRILAILHTV ISFFCIIGYY CLKVPLVIFK
     REKEVARKLE FDGLYITEQP SEDDIKGQWD RLVINTQSFP NNYWDKFVKR KVMDKYGEFY
     GRDRISELLG MDKAALDFSD AREKKKPKKD SSLSAVLNSI DVKYQMWKLG VVFTDNSFLY
     LAWYMTMSVL GHYNNFFFAA HLLDIAMGFK TLRTILSSVT HNGKQLVLTV GLLAVVVYLY
     TVVAFNFFRK FYNKSEDGDT PDMKCDDMLT CYMFHMYVGV RAGGGIGDEI EDPAGDEYEI
     YRIIFDITFF FFVIVILLAI IQGLIIDAFG ELRDQQEQVK EDMETKCFIC GIGNDYFDTV
     PHGFETHTLQ EHNLANYLFF LMYLINKDET EHTGQESYVW KMYQERCWEF FPAGDCFRKQ
     YEDQLN
//
DBGET integrated database retrieval system