ID A0A2I2YZM6_GORGO Unreviewed; 1530 AA.
AC A0A2I2YZM6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Synaptonemal complex protein 2 {ECO:0000313|Ensembl:ENSGGOP00000040178.1};
GN Name=SYCP2 {ECO:0000313|Ensembl:ENSGGOP00000040178.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000040178.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000040178.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000040178.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000040178.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SYCP2 family.
CC {ECO:0000256|ARBA:ARBA00007960}.
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DR EMBL; CABD030117572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030117573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030117574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004062509.1; XM_004062461.1.
DR STRING; 9593.ENSGGOP00000040178; -.
DR Ensembl; ENSGGOT00000067482.1; ENSGGOP00000040178.1; ENSGGOG00000010064.3.
DR GeneID; 101140516; -.
DR KEGG; ggo:101140516; -.
DR CTD; 10388; -.
DR GeneTree; ENSGT00530000063859; -.
DR InParanoid; A0A2I2YZM6; -.
DR OMA; SDWHIES; -.
DR OrthoDB; 5407023at2759; -.
DR Proteomes; UP000001519; Chromosome 20.
DR Bgee; ENSGGOG00000010064; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0000800; C:lateral element; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR GO; GO:0007143; P:female meiotic nuclear division; IBA:GO_Central.
DR GO; GO:0009566; P:fertilization; IEA:Ensembl.
DR GO; GO:0048808; P:male genitalia morphogenesis; IEA:Ensembl.
DR GO; GO:0007140; P:male meiotic nuclear division; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0051093; P:negative regulation of developmental process; IEA:Ensembl.
DR GO; GO:2000242; P:negative regulation of reproductive process; IEA:Ensembl.
DR InterPro; IPR024835; SYCP2-like.
DR InterPro; IPR041322; SYCP2_ARLD.
DR InterPro; IPR040560; SYCP2_SLD.
DR PANTHER; PTHR15607:SF12; SYNAPTONEMAL COMPLEX PROTEIN 2; 1.
DR PANTHER; PTHR15607; SYNAPTONEMAL COMPLEX PROTEIN-RELATED; 1.
DR Pfam; PF18581; SYCP2_ARLD; 1.
DR Pfam; PF18584; SYCP2_SLD; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 9..187
FT /note="Synaptonemal complex protein 2 armadillo-repeat-
FT like"
FT /evidence="ECO:0000259|Pfam:PF18581"
FT DOMAIN 278..389
FT /note="Synaptonemal complex protein 2 Spt16M-like"
FT /evidence="ECO:0000259|Pfam:PF18584"
FT REGION 440..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..1011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..559
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..794
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..997
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1530 AA; 175615 MW; 299C76B3765E2307 CRC64;
MPIRPDLQQL EKCIDDALRK NDFKPLKTLL QIDICEDVKI KCSKQFFHKV DNLICRELNK
EDIHNVSAIL VSVGRCGKNI SVLGQAGLLT MIKQGLIQKM VAWFEKSKDI IQSQGNSKNE
AVLNVIEDLV DLLLVIHDVS DEGKKQVVES FVPRICSLVV DSRVNICIQQ EIIKKMNAML
DKMPQDARKI LSNQEMLILM SSMGERILDA GDYDLQVGIV EALCRMTTEK QRQELAHHWF
SMDFIAKAFK RIKDSEFETD CRIFLNLVNG MLGDKRRVFT FPCLSAFLDK YELQIPSDEK
LEEFWIDFNL GSQTLSFYIA GDNDDHQWEA VTVPEEKVQI YSIEVRESKK LLTIILKNTV
KISNREGKEL LLYFDASLEI TNVTQKIFGA NKHRESIRKQ GISVAKTSLH ILFDASGSQI
LVPESQISPV GEELVSLKEK SKSPKEFAKP SKYIKNSDKG NRNNSQLEKI TPSKRKMSEA
SMIVSGADRY TTRSPVLFSN TSIPPRRRRI KPPLQMTSSA EKPSVSQTSE NRVDNAASLK
SRSSEGRHRR DNTDKHIKTA KCVENTENKN VEFPNQNFSE LQDVIPDSQA AEKRDHTILP
GVLDNICGNK IHSKWACWTP VTNIELCNNQ RASTSSGDTL NQDIVINKKL TKQKSSSSIS
DHNSEGTGKV KYKKEQTDHI KIDKAEVEVC KKHNQQQNHP KYSGQKNTEN AKQSDWPVES
ETTFKSVLLN KTIEESLIYR KKYILSKDVN TATCDKNPSA SKNVQSHRKA EKELTSELNS
WDSKQKKMRE KSKGKEFTNV AESLISQINK RYKTKDDIKS TRKLKESLIN SGFSNKSVVQ
LSKEKVQKKS YRKLKTTFVN VTSECPVNDV YNFNLNGADD PIIKLGIQEF QATAKEACAD
RSIRLVGPRN HDELKSSVKT KDKKIITNHQ KKNLFSDTET EYRCDDSKTD ISWLREPKSK
PQLIDYSRNK NVKNHKSGKS RSSLEKGQPG SKMTPSKNIT KKTDKTIPEG RIRLPRKATK
TKKNYKDLSN SESECEQEFS HSFKENIPVK EENIHSRMKT VKLPKKRQKV FCAETEKELS
KQWKNSSLLK DAIRDNCLDL SPRSLSGSPS SIEVTRCIEK ITEKDFTQDY DCITKSISPY
PKTSSLESLN SNSGVGGTIK SPKNNEKNFL CASESCSPIP RPLFLPRHTP TKSNTIVNRK
KISSLVLTQE TQNCNSYSDV SSYSSEERFM EIESPHINEN YIQSKREESH LASSLSKSSE
GREKMWFDMP CDATHVSGPT QHLSRKRIYI EDNLSNSNEV EMEEKGERRA NLLPKKLCKI
EDADHHIHKM SESVSSLSTN DFSIPWETWQ NEFAGIEMTY ETYERLNSEF KRRNNIRHKM
LSYFTTQSWK TAQQHLRTMN HQSQDSRIKK LDKFQFIIIE ELENFEKDSQ SLKDLEKEFV
DFWEKIFQKF SAYQKSEQQR LHLLKTSLAK SVFCNTDNEE TVFTSEMCLM KEDMKVLQDR
LLKDMLEEEL LNIRRELMSV FMSHERNANV
//
