ID A0A2I2YZM7_GORGO Unreviewed; 1657 AA.
AC A0A2I2YZM7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 {ECO:0000313|Ensembl:ENSGGOP00000040400.1};
GN Name=PREX1 {ECO:0000313|Ensembl:ENSGGOP00000040400.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000040400.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000040400.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000040400.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000040400.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030117101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030117102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030117103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030117104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030117105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000068299.1; ENSGGOP00000040400.1; ENSGGOG00000008023.3.
DR GeneTree; ENSGT00940000159925; -.
DR Proteomes; UP000001519; Chromosome 20.
DR Bgee; ENSGGOG00000008023; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:UniProt.
DR CDD; cd04440; DEP_2_P-Rex; 1.
DR CDD; cd00136; PDZ; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF6; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN; 1.
DR Pfam; PF00610; DEP; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50186; DEP; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 48..239
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 270..391
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 420..495
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 528..596
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 624..671
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1657 AA; 186005 MW; 18BF35302A7A8AEB CRC64;
MPAPQGEPGG DGAGDCAHPD PRTPGAAAPS SGPGQCAAAR ESERQLRLRL CVLNEILGTE
RDYVGTLRFL QSAFLHRIRQ NVADSVEKGL TEENVKVLFS NIEDILEVHK DFLAALEYCL
HPEPQSQHEL GNVFLKFKDK FCVYEEYCSN HEKALRLLVE LNKIPTVRAF LLSCMLLGGR
KTTDIPLEGY LLSPIQRICK YPLLLKELAK RTPGKHPDHP AVQSALQAMK TVCSNINETK
RQMEKLEALE QLQSHMEGWE GSNLTDICTQ LLLQGTLLKI SAGNIQERAF FLFDNLLVYC
KRKSRVTGSK KSTKRTKSIN GSLYIFRGRI NTEVMEVENV EDGTADYHSN GYTVTNGWKI
HNTAKNKWFV CMAKTAEEKQ KWLDAIIRER EQRESLKLGM ERDAYVMIAE KGEKLYHMMM
NKKVNLIKDR RRKLSTVPKC FLGNEFVAWL LEIGEISKTE EGVNLGQALL ENGIIHHVSD
KHQFKNEQVM YRFRYDDGTY KARSELEDIM SKGVRLYCRL HSLYTPVIKD RDYHLKTYKS
VLPGSKLVDW LLAQGDCQTR EEAVALGVGL CNNGFMHHVL EKSEFRDESQ YFRFHADEEM
EGTSSKNKQL RNDFKLVENI LAKRLLILPQ EEDYGFDIEE KNKAVVVKSV QRGSLAEMAG
LQVGRKIYSI NEDLVFLRPF SEVESILNQS FCSRRPLRLL VATKAKEIIK IPDQPDTLCF
QIRGAAPPYV YAVGRGSEAM AAGLCAGQCI LKVNGSNVMN DGAPEVLEHF QAFRSRCEEA
LGLYQWIYHT HEDAQEARAS QEASTEDPSG EQAQEEDQAD SAFPLLSLGP RLSLCEDSPM
VTLTVDNVHL EHGVVYEYVS TAGVRCHVLE KIVEPRGCFG LTAKILEAFA ANDSVFVENC
GRLMALSSAI MTMPHFEFRN ICDTKLESIS QRIACYQEFA AQLKSRVSPP FKQAPLEPHP
LCGLDFCPTN CHINLMEVSY PKTTPSVGRS FSIRFGRKPS LIGLDPEQGH LNPMSYTQHC
ITTMAAPSWK CLPAAEGDPQ GQGLHDGSFG PASGTLGQED RGLSFLLKQE DREIQDAYLQ
LFTKLDVALK EMKQYVTQIN RLLSTITEPT SGGSCDVSLA EEASSLPLVS EESEMDRSDH
GGIKKVCFKV AEEDQEDSGH DTMSYRDSYS ECNSNRDSVL SYTSVRSNSS YLGSDEMGSG
DELPCDMRIP SDKQDKLHGC LEHLFNQVDS INALLKGPVM SRAFEETKHF PMNHSLQEFK
QKEECTIRGR SLIQISIQED PWNLPNSIKT LVDNIQRYVE DGKNQLLLAL LKCTDTELQL
RRDAIFCQAL VAAVCTFSEQ LLAALGYRYN NNGEYEESSR DASRKWLEQV AATGVLLHCQ
SLLSPATVKE ERTMLEDIWV TLSELDNVTF SFKQLDENYV ANTNVFYHIE GSRQALKVVF
YLDSYHFSKL PSRLEGGASL RLHTALFTKV LENVEGLPSP GSQAAEDLQQ DINAQSLEKV
QQYYRKLRAF YLERSNLPTD ASTTAVKIDQ LIRPINALDE LCRLMKSFVH PKPGAAGSVG
AGLIPISSEL CYRLGACQMV MCGTGMQSTL SVSLEQAAIL ARSHGLLPKC IMQATDIMRK
QGPRVEILAK NLRVKDQMPQ GAPRLYRLCQ PPVDGDL
//
