ID A0A2I2YZY4_GORGO Unreviewed; 555 AA.
AC A0A2I2YZY4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=DAB adaptor protein 1 {ECO:0000313|Ensembl:ENSGGOP00000040568.1};
GN Name=DAB1 {ECO:0000313|Ensembl:ENSGGOP00000040568.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000040568.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000040568.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000040568.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000040568.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030003406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030003407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030003408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030003409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030003410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018874612.1; XM_019019067.1.
DR AlphaFoldDB; A0A2I2YZY4; -.
DR SMR; A0A2I2YZY4; -.
DR Ensembl; ENSGGOT00000053201.1; ENSGGOP00000040568.1; ENSGGOG00000024836.3.
DR GeneID; 101140190; -.
DR KEGG; ggo:101140190; -.
DR CTD; 1600; -.
DR GeneTree; ENSGT00940000158038; -.
DR OrthoDB; 2913989at2759; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000024836; Expressed in cerebellum and 4 other cell types or tissues.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR CDD; cd01215; PTB_Dab; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR048559; DAB1/2_SBM.
DR InterPro; IPR048561; Dab_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR47695:SF4; DISABLED HOMOLOG 1; 1.
DR PANTHER; PTHR47695; PID DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF21792; DAB2_SBM; 1.
DR Pfam; PF00640; PID; 1.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 37..169
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 59950 MW; 9EB4FC3D31BBF8CB CRC64;
MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID EVSAARGDKL
CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK TGALQHHHAV HEISYIAKDI
TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV ILDLRDLFQL IYELKQREEL EKKAQKDKQC
EQAVYQTILE EDVEDPVYQY IVFEAGHEPI RDPETEENIY QVPTSQKKEG VYDVPKSQPV
SAVTQLELFG DMSTPPDITS PPTPATPGDA FIPSSSQTLP ASADVFSSVP FGTAAVPSGY
VAMGAVLPSF WGQQPLVQQQ MVMGAQPPVA QVMPGAQPIA WGQPGLFPAT QQPWPTVAGQ
FPPAAFMPTQ TVMPLPAAMF QGPLTPLATV PGTSDSTRSS PQTDKPRQKM GKETFKDFQM
AQPPPVPSRK PDQPSLTCTS EAFSSYFNKV GVAQDTDDCD DFDISQLNLT PVTSTTPSTN
SPPTPAPRQS SPSKSSASHA SDPTTDDIFE EGFESPSKSE EQEAPDGSQA SSNSDPFGEP
SGEPSGDNIS PQAGS
//
