ID A0A2I2Z064_GORGO Unreviewed; 291 AA.
AC A0A2I2Z064;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Failed axon connections homolog, metaxin like GST domain containing {ECO:0000313|Ensembl:ENSGGOP00000040637.1};
GN Name=FAXC {ECO:0000313|Ensembl:ENSGGOP00000040637.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000040637.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000040637.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000040637.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000040637.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FAX family. {ECO:0000256|ARBA:ARBA00006475}.
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DR EMBL; CABD030046834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030046835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030046836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030046837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030046838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2Z064; -.
DR Ensembl; ENSGGOT00000048764.1; ENSGGOP00000040637.1; ENSGGOG00000044046.1.
DR GeneTree; ENSGT00950000182919; -.
DR Proteomes; UP000001519; Chromosome 6.
DR Bgee; ENSGGOG00000044046; Expressed in prefrontal cortex and 3 other cell types or tissues.
DR CDD; cd03193; GST_C_Metaxin; 1.
DR InterPro; IPR026928; FAX/IsoI-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR PANTHER; PTHR12289:SF76; FAILED AXON CONNECTIONS HOMOLOG; 1.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF17172; GST_N_4; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01200; SUF1.1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 7..93
FT /note="Thioredoxin-like fold"
FT /evidence="ECO:0000259|Pfam:PF17172"
FT DOMAIN 146..208
FT /note="Metaxin glutathione S-transferase"
FT /evidence="ECO:0000259|Pfam:PF17171"
FT REGION 254..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 291 AA; 33624 MW; 1818BBF6771F7704 CRC64;
KQTYLSLTHL GCPYCCNYFG GKLSAQGKMP WIEYNHEKVS GTEFIIDFLE EKLGVNLNKN
LGPHERAISR AVTKMVEEHF YWTLAYCQWV DNLNETRKML SLSGGGPFSN LLRWVVCHIT
KGIVKREMHG HGIGRFSEEE IYMLMEKDMR SLAGLLGDKK YIMGPKLSTL DATVFGHLAQ
AMWTLPGTRP ERLIKGELIN LAMYCERIRR KFWPEWHHDD DNTIYESEES SEGSKTHTPL
LDFSFYSRTE TFEDEGAENS FSRTPDTDFT GHSLFDSDVD MDDYTDHEQC K
//
