ID A0A2I2Z090_GORGO Unreviewed; 1272 AA.
AC A0A2I2Z090;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSGGOP00000040601.1};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSGGOP00000040601.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000040601.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000040601.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000040601.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000040601.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; CABD030027005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030027006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030027007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030027008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030027009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030027010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2Z090; -.
DR Ensembl; ENSGGOT00000043301.1; ENSGGOP00000040601.1; ENSGGOG00000013705.3.
DR GeneTree; ENSGT00940000154127; -.
DR Proteomes; UP000001519; Chromosome 4.
DR Bgee; ENSGGOG00000013705; Expressed in adult mammalian kidney and 5 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 263..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 427..454
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 971..1005
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1272 AA; 144255 MW; FD1B735E65D12A42 CRC64;
VRKGLSLDGL GYGERGCQGP GSLPPRDPQV APRSGPGLRT PPGRSGAGPE SSTQDLPCMI
WPKVECCHFK TAVEAPLGMK LDKKMEVFIP LSTSAASSGP WAHSLFAFIP SWPKKNLFKR
ESPITHHLFN TLTQIPEVSG SSEAQTARIW LLVNNTKTTS SANLSELLLL DSIAGLTIWD
SIGNRTSEGF QAFSKKFLQV GDAFAVSYAA TLQAGDLGNG ESLKLPAQLT FQSSSRNRTQ
LKALFSITAE ENITVLPHHS LHAAGFFIAF LLSLVLTWAA LFLMVRYQCL KGNMLTRHRV
WQYESKLEPL PFTSADGVNE DLSLNDQMID ILSSEDPGSM LQALEELEIA TLNRADADLE
ACRTQISKDI IALLLKNLTS SGHLSLQVER KMSAVFKKQF LLLENEIQEE YDRKMVALTA
ECDLETRKKM ENQYQREMMA MEEAEELLKR ASERSAVECS NLLRTLHGLE QEHLRKSLAL
QQEEDFAKAH RQLAVFQRNE LRSIFFTQIK SAIFKGELKP EAAKMLLQNY SKIQENVEEL
MDFFQASKRY HLSKRFGHRE YLVQNLQSSE TRVQGLLSTA AAQLTHLIQK HERAGYLDED
QMEMLLERAQ TEVFSIKQKL DNDLKQEKKK LHQKLITKRR QELLQKHREQ RREQVSIGEA
FQAVEDAGQY LHQRRSLMEE HGAALEELQE RLDQAALDDL RTLTLSLFEK ATDELRRLQN
SAMTQELLKR GVPWLFLQQI LEEHGKEMAA RAEQLEGEER DRDQEGVQSV RQRLKDDAPE
AVTEEQAELR RWEHLIFMKL CSSVFSLSEE ELLRMRQEVH GCFAQMDRSL ALPKIRARVL
LQQFQTAWRE AEFVKLDQAV AAPELQQQSK VRKSRSKSKS KGELLKKCIE DKIHLCEEQA
SEDLVEKVRG ELLRERVQRM EAQEGGFAQS LVALQFQKAS RVTETLSAYT ALLSIQDLLL
EELSASEMLT KSACTQILES HSRELQELER KLEDQLMQQE AAQQQQALAS WQQWVADGPG
ILNEPGEVDS ERQVSTALQQ ALSKSQTLLE QHQQCLREEQ QNSVVLEDLL ENMEADTFAT
LCSQELKLAS YLARMAMVPG ATLRRLLSVV LPTASQPQLL ALLDSATERH ADHAAESDGG
VEQVDVGRRR KHQSWWQALD GKLRGDLISR GLEKMLWARK RKQSILKKTC LPLRERMIFS
GKGSWPHLSL EPIGELAPVP IVGAETIDLL NTGEKLFIFR NPKEPEISLH VPPRKKKNFL
NAKKAMRALG MD
//