ID A0A2I2Z0F8_GORGO Unreviewed; 641 AA.
AC A0A2I2Z0F8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=SLCO3A1 {ECO:0000313|Ensembl:ENSGGOP00000040458.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000040458.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000040458.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000040458.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000040458.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR EMBL; CABD030097902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030097903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030097904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030097905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030097906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030097907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018866649.1; XM_019011104.1.
DR AlphaFoldDB; A0A2I2Z0F8; -.
DR STRING; 9593.ENSGGOP00000040458; -.
DR Ensembl; ENSGGOT00000068198.1; ENSGGOP00000040458.1; ENSGGOG00000001633.4.
DR GeneTree; ENSGT01080000257410; -.
DR InParanoid; A0A2I2Z0F8; -.
DR OMA; NINCECQ; -.
DR Proteomes; UP000001519; Chromosome 15.
DR Bgee; ENSGGOG00000001633; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0009925; C:basal plasma membrane; IEA:Ensembl.
DR GO; GO:0015132; F:prostaglandin transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0015732; P:prostaglandin transport; IBA:GO_Central.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF86; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 3A1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 20..45
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 52..69
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 119..136
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 157..185
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 205..227
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 366..385
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 480..506
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 518..541
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 569..592
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 409..457
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
SQ SEQUENCE 641 AA; 68822 MW; 7ADE6D489949AE36 CRC64;
MMTKVSVLTT LERRFNLQSA DVGVIASSFE IGNLALILFV SYFGARGHRP RLIGCGGIVM
ALGALLSALP EFLTHQYKYE AGEIRWGAEG RDVCAANGSG GDEGPDPDLI CRNRTATNMM
YLLLIGAQVL LGIGATPVQP LGVSYIDDHV RRKDSSLYIG ILFTMLVFGP ACGFILGSFC
TKIYVDAVFI DTSNLDITPD DPRWIGAWWG GFLLCGALLF FSSLLMFGFP QSLPPHSDPA
MESEQAMLSE REYERPKPSN GVLRHPLEPD SSASCFQQLR VIPKVTKHLL SNPVFTCIIL
AACMEIAVVA GFAAFLGKYL EQQFNLTTSS ANQLLGMTAI PCACLGIFLG GLLVKKLSLS
ALGAIRMAML VNLVSTACYV SFLFLGCDTG PVAGVTVPYG NSTAPGSALD PYSPCNNNCE
CQTDSFTPVC GADGITYLSA CFAGCNSTNL TGCACLTTVP AENATVVPGK CPSPGCQEAF
LTFLCVMCIC SLIGAMAQTP SVIILIRTVS PELKSYALGV LFLLLRLLGF IPPPLIFGAG
IDSTCLFWST FCGEQGACVL YDNVVYRYLY VSIAIALKSF AFILYTTTWQ CLRKNYKRYI
KNHEGGLSTT SEPDRIQNKE TMTSCGGVLE ATRAAGPQSL L
//
