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Database: UniProt
Entry: A0A2I2Z1E1_GORGO
LinkDB: A0A2I2Z1E1_GORGO
Original site: A0A2I2Z1E1_GORGO 
ID   A0A2I2Z1E1_GORGO        Unreviewed;      4957 AA.
AC   A0A2I2Z1E1;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 6.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSGGOP00000040815};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000040815, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000040815, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000040815}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
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DR   EMBL; CABD030113423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGGOT00000056932; ENSGGOP00000040815; ENSGGOG00000015461.
DR   GeneTree; ENSGT00940000155288; -.
DR   Proteomes; UP000001519; Chromosome 19.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0031674; C:I band; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030314; C:junctional membrane complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0043931; P:ossification involved in bone maturation; IEA:Ensembl.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4480   4500       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4757   4779       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4838   4861       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      107    162       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      169    214       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      220    274       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      280    337       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      345    402       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      591    807       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1023   1218       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1366   1580       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1879   1934       {ECO:0000256|SAM:Coils}.
FT   COILED     2923   2943       {ECO:0000256|SAM:Coils}.
FT   COILED     3685   3705       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4957 AA;  557930 MW;  185E44829A6F0E7E CRC64;
     CLSPGGQGCS ERCPSVPQDD EVVLQCSATV LKEQLKLCLA AEGFGNRLCF LEPTSNAQNV
     PPDLAICCFV LEQSLSVRAL QEMLANTVEA GVEALNLDKW SSQGGGHRTL LYGHAILLRH
     AHSRMYLSCL TTSRSMTDKL AFDVGLQEDA TGEACWWTMH PASKQRSEGE KVRVGDDIIL
     VSVSSERYLH LSTASGELQV DASFMQTLWN MNPICSRCEE GFVTGGHVLR LFHGHMDECL
     TISPADSDDQ RRLVYYEGGA VCTHARSLWR LEPLRISWSG SHLRWGQPLR VRHVTTGRYL
     ALTEDQGLVV VDASKAHTKA TSFCFRISKE KLDVAPKRDV EGMGPPEIKY GESLCFVQHV
     ASGLWLTYAA PDPKALRLGV LKKKAMLHQE GHMDDALSLT RCQQEESQAA RMIHSTNGLY
     NQFIKSLDSF SGKPRGSGPP AGTALPIEGV ILSLQDLIIY FEPPSEDLQH EEKQSKLRSL
     RNRQSLFQEE GMLSMVLNCI DRLNVYTTAA HFAEFAGEEA AESWKEIVNL LYELLASLIR
     GNRSNCALFS TNLDWLVSKL DRLEASSGIL EVLYCVLIES PEVLNIIQEN HIKSIISLLD
     KHGRNHKVLD VLCSLCVCNG VAVRSNQDLI TENLLPGREL LLQTNLINYV TSIRPNIFVG
     RAEGTTQYSK WYFEVMVDEV TPFLTAQATH LRVGWALTEG YSPYPGGGEG WGGNGVGDDL
     YSYGFDGLHL WTGHVARPVT SPGQHLLAPE DVISCCLDLS VPSISFRING CPVQGVFESF
     NLDGLFFPVV SFSAGVKVRF LLGGRHGEFK FLPPPGYAPC HEAVLPRERL HLEPIKEYRR
     EGPRGPHLVG PSRCLSHTDF VPCPVDTVQI VLPPHLERIR EKLAENIHEL WALTRIEQGW
     TYGPVRDDNK RLHPCLVDFH SLPEPERNYN LQMSGETLKT LLALGCHVGM ADEKAEDNLK
     KTKLPKTYMM SNGYKPAPLD LSHVRLTPAQ TTLVDRLAEN GHNVWARDRV GQGWSYSAVQ
     DIPARRNPRL VPYRLLDEAT KRSNRDSLCQ AVRTLLGYGY NIEPPDQEPS QVENQSRCDR
     VRIFRAEKSY TVQSGRWYFE FEAVTTGEMR VGWARPELRP DVELGADELA YVFNGHRGQR
     WHLGSEPFGR PWQPGDVVGC MIDLTENTII FTLNGEVLMS DSGSETAFRE IEIGDGFLPV
     CSLGPGQVGH LNLGQDVSSL RFFAICGLQE GFEPFAINMQ RPVTTWFSKG LPQFEPVPLE
     HPHYEVSRVD GTVDTPPCLR LTHRTWGSQN SLVEMLFLRL SLPVQFHQHF RCTAGATPLA
     PPGLQPPAED EARAAEPDPD YENLRRSAGG WGEAENGKEG TAKEGAPGGT PQAGGEAQPA
     RAENEKDATT EKNKKRGFLF KAKKVAMMTQ PPATPTLPRL PHDVVPADNR DDPEIILNTT
     TYYYSVRVFA GQEPSCVWAG WVTPDYHQHD MSFDLSKVRV VTVTMGDEQG NVHSSLKCSN
     CYMVWGGDFV SPGQQGRISH TDLVIGCLVD LATGLMTFTA NGKESNTFFQ VEPNTKLFPA
     VFVLPTHQNV IQFELGKQKN IMPLSAAMFQ SERKNPAPQC PPRLEMQMLM PVSWSRMPNH
     FLQVETRRAG ERLGWAVQCQ EPLTMMALHI PEENRCMDIL ELSERLDLQR FHSHTLCLYR
     AVCALGNNRV AHALCSHVDQ AQLLHALEDA HLPGPLRAGY YDLLISIHLE SACRSRRSML
     SEYIVPLTPE TRAITLFPPG RSTENGHPRH GLPGVGVTTS LRPPHHFSPP CFVAALPAAG
     AAEAPARLSP AIPLEALRDK ALRMLGEAVR DGGQHARDPV GGSVEFQFVP VLKLVSTLLV
     MGIFGDEDVK QILKMIEPEV FTEEEEEEEE EEEDEEEDEE EKEEDEEETA QEKEDEEKEE
     EEAAEGEKEE GLEEGLLQMK LPESVKLQMC HLLEYFCDQE LQHRVESLAA FAERYVDKLQ
     ANQRSRYGLL IKAFSMTAAE TARRTREFRS PPQEQINMLL QFKDGTDEED CPLPEEIRQD
     LLDFHQDLLA HCGIQLDGEE EEPEEETTLG SRLMSLLEKV RLVKKKEEKP EEERSAEESK
     PRSLQELVSH MVVRWAQEDF VQSPELVRAM FSLLHRQYDG LGELLRALPR AYTISPSSVE
     DTMSLLECLG QIRSLLIVQM GPQEENLMIQ SIGNIMNNKV FYQHPNLMRA LGMHETVMEV
     MVNVLGGGES KEIRFPKMVT SCCRFLCYFC RISRQNQRSM FDHLSYLLEN SGIGLGMQGS
     TPLDVAAASV IDNNELALAL QEQDLEKVVS YLAGCGLQSC PMLVAKGYPD IGWNPCGGER
     YLDFLRFAVF VNGESVEENA NVVVRLLIRK PECFGPALRG EGGSGLLAAI EEAIRISEDP
     ARDGPGIRRD RRREHFGEEP PEENRVHLGH AVMSFYAALI DLLGRCAPEM HLIQAGKGEA
     LRIRAILRSL VPLEDLVGII SLPLQIPTLG KDGALVQPKM SASFVPDHKA SMVLFLDRVY
     GIENQDFLLH VLDVGFLPDM RAAASLDTAT FSTTEMALAL NRYLCLAVLP LITKCAPLFA
     GTEHRAIMVD SMLHTVYRLS RGRSLTKAQR DVIEDCLMSL CRYIRPSMLQ HLLRRLVFDV
     PILNEFAKMP LKLLTNHYER CWKYYCLPTG WANFGVTSEE ELHLTRKLFW GIFDSLAHKK
     YDPELYRMAM PCLCAIAGAL PPDYVDASYS SKAEKKATVD AEGNFDPRPV ETLNVIIPEK
     LDSFINKFAE YTHEKWAFDK IQNNWSYGEN IDEELKTHPM LRPYKTFSEK DKEIYRWPIK
     ESLKAMIAWE WTIEKAREGE EEKTEKKKTR KISQSAQTYD PREGYNPQPP DLSAVTLSRE
     LQAMAEQLAE NYHNTWGRKK KQELEAKGGG THPLLVPYDT LTAKEKARDR EKAQELLKFL
     QMNGYAVTRG LKDMELDSSS IEKRFAFGFL QQLLRWMDIS QEFIAHLEAV VSSGRVEKSP
     HEQEIKFFAK ILLPLINQYF TNHCLYFLST PAKVLGSGGH ASNKEKEMIT SLFCKLAALV
     RHRVSLFGTD ASAVVNCLHI LARSLDARTV MKSGPEIVKA GLRSFFESAS EDIEKMVENL
     RLGKVSQART QVKGVGQNLT YTTVALLPVL TTLFQHIAQH QFGDDVILDD VQVSCYRTLC
     SIYSLGTTKN TYVEKLRPAL GECLARLAAA MPVAFLEPQL NEYNACSVYT TKSPRERAIL
     GLPNSVEEMC PDIPVLERLM ADIGGLAESG ARYTEMPHVI EITLPMLCSY LPRWWERGPE
     APPPALPAGA PPPCTAVTSD HLNSLLGNIL RIIVNNLGID EASWMKRLAV FAQPIVSRAR
     PELLQSHFIP TIGRLRKRAG KVVSEEEQLR LEAKAEAQEG ELLVRDEFSV LCRDLYALYP
     LLIRYVDNNR AQWLTEPNPS AEELFRMVGE IFIYWSKSHN FKREEQNFVV QNEINNMSFL
     TADNKSKMAK VGSGGSDQER TKKKRRGDRY SVQTSLIVAT LKKMLPIGLN MCAPTDQDLI
     TLAKTRYALK DTDEEVREFL HNNLHLQGKV EGSPSLRWQM ALYRGVPGRE EDADDPEKIV
     RRVQEVSAVL YYLDQTEHPY KSKKAVWHKL LSKQRRRAVV ACFRMTRMGG REARRRAHRA
     CNMFLESYKA AWIVTEDHSF EDRMIDDLSK AGEQEEEEEE VEEKKPDPLH QLVLHFSRTA
     LTEKSKLDED YLYMAYADIM AKSCHLEEGG ENGEAEEEVE VSFEEKEMEK QRLLYQQARL
     HTRGAAEMVL QMISACKGET GAMVSSTLKL GISILNGGNA EVQQKMLDYL KDKKEVGFFQ
     SIQALMQTCS VLDLNAFERQ NKAEGLGMVN EDGTVINRQN GNSPREKVMA DDEFTQDLFR
     FLQLLCEGHN NDFQNYLRTQ TGNTTTINII ICTVDYLLRL QESISDFYWY YSGKDVIEEQ
     GKRNFSKAMS VAKQVFNSLT EYIQGPCTGN QQSLAHSRLW DAVVGFLHVF AHMMMKLAQV
     REHVWTRVPL EDSSQIELLK ELLDLQKDMV VMLLSLLEGN VVNGMIARQM VDMLVESSSN
     VEMILKFFDM FLKLKDIVGS EAFQDYVTDP RGLISKKDFQ KAMDSQKQFS GPEIQFLLSC
     SEADENEMIN CEEFANRFQE PARDIGFNVA VLLTNLSEHV PHDPRLHNFL ELAESILEYF
     RPYLGRIEIM GASRRIERIY FEISETNRAQ WEMPQVKESK RQFIFDVVNE GGEAEKMELF
     VSFCEDTIFE MQIAAQISEP EGEPETDEDE GAGAAKTRPK KPRRNPPSGD EVHGEQPAGP
     GGDADGEGAS EGAGEAAEGA GDEEEAVHEA GPGGADGAVA VTDGGPFRPE GAGGLGDMGD
     TTPAEPPTPE GSPILKRKLG VREQAGFWGF GKMGDWREEE SPAGAENGEK EEVPEPPPEP
     PKKQAPPSPP PKKEEAGGEF WGELEVQRVK FLNYLSRNFY TLRFLALFLA FAINFILLFY
     KVSDSPPGED DMEGSAAGDV SGAGSGGGSG WGLGAGEEAE GDEDENMVYY FLEESTGYME
     PALRCLSLLH TLVAFLCIIG YNCLKVPLVI FKREKELARK LEFDGLYITE QPEDDDVKGQ
     WDRLVLNTPS FPSNYWDKFV KRKVLDKHGD IYGRERIAEL LGMDLATLEI TAHNERKPNP
     PPGLLTWLMS IDVKYQIWKF GVIFTDNSFL YLGWYMVMSL LGHYNNFFFA AHLLDIAMGV
     KTLRTILSSV THNGKQLVMT VGLLAVVVYL YTVVAFNFFR KFYNKSEDED EPDMKCDDMM
     TCYLFHMYVG VRAGGGIGDE IEDPAGDEYE LYRVVFDITF FFFVIVILLA IIQGLIIDAF
     GELRDQQEQV KEDMETKCFI CGIGSDYFDT TPHGFETHTL EEHNLANYMF FLMYLINKDE
     TEHTGQESYV WKMYQERCWD FFPAGDCFRK QYEDQLS
//
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