ID A0A2I2Z292_GORGO Unreviewed; 889 AA.
AC A0A2I2Z292;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Unconventional myosin-Id {ECO:0000256|ARBA:ARBA00039641};
GN Name=MYO1D {ECO:0000313|Ensembl:ENSGGOP00000041282.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000041282.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000041282.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000041282.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000041282.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Early endosome
CC {ECO:0000256|ARBA:ARBA00004412}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Perikaryon
CC {ECO:0000256|ARBA:ARBA00004484}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; CABD030038356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030038357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030038358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030038359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030038360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030038361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030038362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030038363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030038364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030038365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2Z292; -.
DR Ensembl; ENSGGOT00000057322.1; ENSGGOP00000041282.1; ENSGGOG00000000276.3.
DR GeneTree; ENSGT00940000157411; -.
DR Proteomes; UP000001519; Chromosome 5.
DR Bgee; ENSGGOG00000000276; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF417; UNCONVENTIONAL MYOSIN-ID; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1..607
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 724..889
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT REGION 484..506
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 14..21
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 889 AA; 102651 MW; 569F3AE724AEAE2E CRC64;
MKRRSKDTCI VISGESGAGK TEASKYIMQY IAAITNPSQR AEVERVKNML LKSNCVLEAF
GNAKTNRNDN SSRFGKYMDI NFDFKGDPIG GHINNYLLEK SRVIVQQPGE RSFHSFYQLL
QGGSEQMLRS LHLQKSLSSY NYIHVGAQLK SSINDAAEFR VVADAMKVIG FKPEEIQTVY
KILAAILHLG NLKFVVDGDT PLIENGKVVS IIAELLSTKT DMVEKALLYR TVATGRDIID
KQHTEQEASY GRDAFAKAIY ERLFCWIVTR INDIIEVKNY DTTIHGKNTV IGVLDIYGFE
IFDNNSFEQF CINYCNEKLQ QLFIQLVLKQ EQEEYQREGI PWKHIDYFNN QIIVDLVEQQ
HKGIIAILDD ACMNVGKVTD EMFLEALNSK LGKHAHFSSR KLCASDKILE FDRDFRIRHY
AGDVVYSVIG FIDKNKDTLF QDFKRLMYNS SNPVLKNMWP EGKLSITEVT KRPLTAATLF
KNSMIALVDN LASKEPYYVR CIKPNDKKSP QIFDDERCRH QVEYLGLLEN VRVRRAGFAF
RQTYEKFLHR YKMISEFTWP NHDLPSDKEA VKKLIERCGF QDDVAYGKTK IFIRTPRTLF
TLEELRAQML IRIVLFLQKV WRGTLARMRY KRTKAALTII RYYRRYKVKS YIHEVARRFH
GVKTMRDYGK HVKWPSPPKV LRRFEEALQT IFNRWRASQL IKSIPASDLP QVRAKVAAME
MLKGQRADLG LQRAWEGNYL ASKPDTPQTS GTFVPVANEL KRKDKYMNVL FSCHVRKVNR
FSKVEDRAIF VTDRHLYKMD PTKQYKVMKT IPLYNLTGLS VSNGKDQLVV FHTKDNKDLI
VCLFSKQPTH ESRIGELVGV LVNHFKRLRR ADHELGLVAG TCSPSYSGG
//
