ID A0A2I2Z2U6_GORGO Unreviewed; 2177 AA.
AC A0A2I2Z2U6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Calcineurin binding protein 1 {ECO:0000313|Ensembl:ENSGGOP00000041487.1};
GN Name=CABIN1 {ECO:0000313|Ensembl:ENSGGOP00000041487.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000041487.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000041487.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000041487.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000041487.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CABD030120404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030120405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030120406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030120407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030120408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030120409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000052138.1; ENSGGOP00000041487.1; ENSGGOG00000001892.3.
DR GeneTree; ENSGT00390000008529; -.
DR Proteomes; UP000001519; Chromosome 22.
DR Bgee; ENSGGOG00000001892; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:InterPro.
DR CDD; cd13839; MEF2_binding; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR033053; Hir3/CABIN1.
DR InterPro; IPR015134; MEF2-bd.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR15502; CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED; 1.
DR PANTHER; PTHR15502:SF7; CALCINEURIN-BINDING PROTEIN CABIN-1; 1.
DR Pfam; PF09047; MEF2_binding; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 2.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 97..130
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 131..164
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 2113..2147
FT /note="Calcineurin-binding protein cabin-1 MEF2-binding"
FT /evidence="ECO:0000259|Pfam:PF09047"
FT REGION 318..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1256..1433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1625..1798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1873..2122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2154..2177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1256..1278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1314..1328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1329..1360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1367..1381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1385..1401
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1699..1713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1755..1769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1932..1948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1987..2001
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2027..2041
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2043..2065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2163..2177
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2177 AA; 241525 MW; CD1820FF0C20FFE5 CRC64;
MTDISKQLIR IAALNASSTV EDDHEGSFKS HKTQTKEAQE AEAFALYHKA LDLQKHDRFE
ESAKAYHELL EARLLREAVS SGDEKEGLKH PGLILKYSTY KNLAQLAAQR EDLETAMEFY
LEAVMLDSTD VNLWYKIGHV ALRLIRIPLA RHAFEEGLRC NPDHWPCLDN LITVLYTLSD
YTTCLYFICK ALEKDCRYSK GLVLKEKIFE EQPCLRKDSL RMFLKCWKCL GESLLAMYNH
LTTCEPPRPS LGKRIDLSDY QDPSQPLESS MVVTPVNVIQ PSTVSTNPAV AVAEPVVSYT
SVATTSFPLH SPGLLETGAP VGDISGGDKS KKGVKRKKIS EESGETAKRR SARVRNTKCK
KEEKVDFQEL LMKFLPSRLR KLDPEEEDDS FNNYEVQSEA KLESFPSIGP QRLSFDSATF
MESEKQDVHE FLLENLTNGG ILELMMRYLK AMGHKFLLRW PPGLAEVVLS VYHSWRRHST
SLPNPLLRDC SNKHIKDMML MSLSCMELQL DQWLLTKGRS SAVSPRNCPA GMVSGRFGPD
FPGTHCLGDL LQLSFASSQR DLFEDGWLEF VVRVYWLKAR FLALQGDMEQ ALENYDICTE
MLQSSTAIHV EAGAERRDIV IRLPNLHNDS VVSLEEIDKN LKSLERCQSL EEIQRLYEAG
DYKAVVHLLR PTLCTSGFDR AKHLEFMTSI PERPAQLLLL QDSLLWLKDY RQCFECSDVA
LNEAVQQMVN SSEAAAKEEW VATVTQLLMG IEQALSADSS GSILKVSSST TGLVRLTNNL
IQVIDCSMAV QEEAKEPHVS SVLPWIILHR IIWQEEDTFH SLCHQQQLQN PAEEGMSEAP
MLPSSLMLLN TAHEYLGRRS WCCNSDGALL RFYVRVLQKE LAASTSEDTH PYKEELETAL
EQCFYCLYSF PSKKSKARYL EEHSAQQVDL IWEDALFMFE YFKPKTLPEF DSYKTSTVSA
DLANLLKRIA TIVPRTERPA LSLDKVSAYI EGTSTEVPCL PEGADPSPPV VNELYYLLAD
YHFKNKEQSK AIKFYMHDIC ICPNRFDSWA GMALARASRI QDKLNSNELK SDGPIWKHAT
PVLNCFRRAL EIDSSNLSLW IEYGTMSYAL HSFASRQLKQ WRGELPPELV QQMEGRRDSM
LETAKHCFTS AARCEGDGDE EEWLIHYMLG KVAEKQQQPP TVYLLHYRQA GHYLHEEAAR
YPKKIHYHNP PELAMEALEV YFRLHASILK LLGKPDSGVG AEVLVNFMKE AAEGPFARGE
EKNTPKASEK EKACLVDEDS HSSAGTLPGP GASLPSSSGP GLTSPPYTAT PIDHDYVKCK
KPHQQATPDD RSQDSTAVAL SDSSSTQDFF NEPTSLLEGS RKSYTEKRLP ILSSQAGATG
KDLQGATEER GKNEESLEST EGFRAAEQGV QKPAAETPAS ACIPGKPSAS TPTLWDGKKR
GDLPGEPVAF PQGLPAGAEE QRQFLTEQCI ASFRLCLSRF PQHYKSLYRL AFLYTYSKTH
RNLQWARDVL LGSSIPWQQL QHMPAQGLFC ERNKTNFFNG IWRIPVDEID RPGSFAWHMN
RSIVLLLKVL AQLRDHSTLL KVSSMLQRTP DQGKKYLRDA DRQVLAQRAF ILTVKVLEDT
LSELAEGSER PGPKVCGLPG ARMTTDVSHK ASPEDGQEGL PQPKKPPLAD GSGPGPEPGG
KVGLLNHRPV AMDAGDSADQ SGEWKDKESP RAGPTEPMDT SEATVCHSDL ERTPPLLPGR
PARDQGPESR PTELSLEELS ISARQQPTPL TPAQPAPAPA PATTTGTRAG GHPEEALSRL
SRKRKLLEDT ESGKTLLLDA YRVWQQGQKG VAYDLGRVER IMSETYMLIK QVDEEAALEQ
AVKFCQVHLG AAAQRQASGD TPTTPKHPKD SRENFFPVTV VPTAPDPVPA DSVQRPSDAH
TKPRPALAAT TTIITCPPSA SASTLDQSKD LGPPRPHRPE ATPSMASLGP EGEELAGVAE
GTSFPPQEPR HSPQVKTAPT SSPAEPHCWP AEAALGTGAE PTCSQEGKLR PEPRRDGEAQ
EAASETQPLS SPPTAASSKA PSSGSAQPPE GHPGKPEPSR AKSRPLPNMP KLVIPSAATK
FPPEITVTPP TPTLLSPKGS ISEETKQKLK SAILSAQSAA NVRKESLCQP ALEVLETSSQ
ESSLESETDE DDDYMDI
//
