ID A0A2I2Z3F7_GORGO Unreviewed; 2099 AA.
AC A0A2I2Z3F7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Dedicator of cytokinesis 9 {ECO:0000313|Ensembl:ENSGGOP00000041525.1};
GN Name=DOCK9 {ECO:0000313|Ensembl:ENSGGOP00000041525.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000041525.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000041525.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000041525.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000041525.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; CABD030090550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090555; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9593.ENSGGOP00000041525; -.
DR Ensembl; ENSGGOT00000042555.1; ENSGGOP00000041525.1; ENSGGOG00000014914.3.
DR GeneTree; ENSGT00940000155972; -.
DR InParanoid; A0A2I2Z3F7; -.
DR OMA; YRQDNNK; -.
DR Proteomes; UP000001519; Chromosome 13.
DR Bgee; ENSGGOG00000014914; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11698; DHR2_DOCK9; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF77; DEDICATOR OF CYTOKINESIS PROTEIN 9; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 173..280
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 639..817
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1604..2066
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 289..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1240..1282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2099 AA; 239970 MW; 6D1780EC5D5380BC CRC64;
MQADKCRTSS RSVKKELVIE SPLQYKDAAQ GEVEAESPGP VPAKPKLIEP LDYENVIVQK
KTQILNDCLR EMLLFPYDDF QTAILRRQGR YICSTVPAKA EEEAQSLFVT ECIKTYNSDW
HLVNYKYEDY SGEFRQLPNK VVKLDKLPVH VYEVDEEVDK DEDAASLGSQ KGGITKHGWL
YKGNMNSAIS VTMRSFKRRF FHLIQLGDGS YNLNFYKDEK ISKEPKGSIF LDSCMGVVQN
NKVRRFAFEL KMQDKSSYLL AADSEVEMEE WITILNKILQ LNFEAAMQEK RNGDSHEDDE
QSKLEGSGSG LDSYLPELAK SAREAEIKLK SESRVKLFYL DPDAQKLDFS SAEPEVKPFE
EKFGKRILVK CNDLSFNLQC CVAENEEGPT TNVEPFFVTL SLFDIKYNRK ISADFHVDLN
HFSVRQMLAT TSPALMNGSG QSPSVLKGIL HEAAMQYPKQ GIFSVTCPHP DIFLVARIEK
VLQGSITHCA EPYMKSSDSS KVAQKVLKNA KQACQRLGQY RMPFAWAART LFKDASGNLD
KNARFSAIYR QDSNKLSNDD MLKLLADFRK PEKMAKLPVI LGNLDITIDN VSSDFPNYVN
SSYIPTKQFE TCSKTPITFE VEEFVPCIPK HTQPYTIYTN HLYVYPKYLK YDSQKSFAKA
RNIAICIEFK DSDEEDSQPL KCIYGRPGGP VFTRSAFAAV LHHHQNPEFY DEIKIELPTQ
LHEKHHLLLT FFHVSCDNSS KGSTKKRDVV ETQVGYSWLP LLKDGRVVTS EQHIPVSANL
PSGYLGYQEL GMGRHYGPEI KWVDGGKPLL KISTHLVSTV YTQDQHLHNF FQYCQKTESG
AQALGNELVK YLKSLHAMEG HVMIAFLPTI LNQLFRVLTR ATQEEVAVNV TRVIVHVVAQ
CHEEGLESHL RSYVKYAYKA EPYVASEYKT VHEELTKSMT TILKPSADFL TSNKLLKYSW
FFFDVLIKSM AQHLIENSKV KLLRNQRFPA SYHHAVETVV NMLMPHITQK FRDNPEASKN
ANHSLAVFIK RCFTFMDRGF VFKQINNYIS CFAPGDPKTL FEYKFEFLRV VCNHEHYIPL
NLPMPFGKGR IQRYQDLQLD YSLTDEFCRN HFLVGLLLRE VGTALQEFRE VRLIAISVLK
NLLIKHSFDD RYASRSHQAR IATLYLPLFG LLIENVQRIN VRDVSPFPVN AGMTVKDESL
ALPAVNPLVT PQKGSTLDNS LHKDLLGAIS GIASPYTTST PNINSVRNAD SRGSLISTDS
GNSLPERNSE KNNSLDKHQQ SSTLGNSVVR CDKLDQSEIK SLLMCFLYIL KSMSDDALFT
YWNKASTSEL MDFFTISEVC LHQFQYMGKR YIARTGMMHA RLQQLGSLDN SLTFNHSYGH
SDADVLHQSL LEANIATEVC LTALDTLSLF TLAFKNQLLA DHGHNPLMKK VFDVYLCFLQ
KHQSETALKN VFTALRSLIY KFPSTFYEGR ADMCAALCYE ILKCCNSKLS SIRTEASQLL
YFLMRNNFDY TGKKSFVRTH LQVIISVSQL IADVVGIGGT RFQQSLSIIN NCANSDRLIK
HTSFSSDVKD LTKRIRTVLM ATAQMKEHEN DPEMLVDLQY SLAKSYASTP ELRKTWLDSM
ARIHVKNGDL SEAAMCYVHV TALVAEYLTR KEAVQWEPPL LPHSHSACLR RSRGGMFRQG
CTAFRVITPN IDEEASMMED VGMQDVHFNE DVLMELLEQC ADGLWKAERY ELIADIYKLI
IPIYEKRRDF ERLAHLYDTL HRAYSKVTEV MHSGRRLLGT YFRVAFFGQQ YQFTDSETDV
EGFFEDEDGK EYIYKEPKLT PLSEISQRLL KLYSDKFGSE NVKMIQDSGK VNPKDLDSKY
AYIQVTHVIP FFDEKELQER KTEFERSHNI RRFMFEMPFT QTGKRQGGVE EQCKRRTILT
AIHCFPYVKK RIPVMYQHHT DLNPIEVAID EMSKKVAELR QLCSSAEVDM IKLQLKLQGS
VSVQVNAGPL AYARAFLDDT NTKRYPDNKV KLLKEVFRQF VEACGQALAV NERLIKEDQL
EYQEEMKANY REMAKELSEI MHEQVRAALA PTTWSSWLGV ASIPYPDLGR LISFQNCDI
//