ID A0A2I2Z4H6_GORGO Unreviewed; 632 AA.
AC A0A2I2Z4H6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Ligand of numb-protein X 1 {ECO:0000313|Ensembl:ENSGGOP00000041910.1};
GN Name=LNX1 {ECO:0000313|Ensembl:ENSGGOP00000041910.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000041910.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000041910.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000041910.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000041910.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030031093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030031094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030031095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030031096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030031097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030031098; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030031099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030031100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030031101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030031102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004038727.1; XM_004038679.2.
DR AlphaFoldDB; A0A2I2Z4H6; -.
DR Ensembl; ENSGGOT00000058928.1; ENSGGOP00000041910.1; ENSGGOG00000010056.3.
DR GeneID; 101152604; -.
DR KEGG; ggo:101152604; -.
DR CTD; 84708; -.
DR GeneTree; ENSGT00940000158757; -.
DR Proteomes; UP000001519; Chromosome 4.
DR Bgee; ENSGGOG00000010056; Expressed in prefrontal cortex and 5 other cell types or tissues.
DR CDD; cd00992; PDZ_signaling; 4.
DR Gene3D; 2.30.42.10; -; 4.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR19964:SF14; E3 UBIQUITIN-PROTEIN LIGASE LNX; 1.
DR PANTHER; PTHR19964; MULTIPLE PDZ DOMAIN PROTEIN; 1.
DR Pfam; PF00595; PDZ; 4.
DR SMART; SM00228; PDZ; 4.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR PROSITE; PS50106; PDZ; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..632
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014133839"
FT DOMAIN 178..263
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 285..368
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 411..497
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 542..628
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 93..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 632 AA; 69617 MW; 1B3202F115DEE37E CRC64;
MKALLLLVLP WLSPANYIDN VGNLHFLYSE LCKGASHYGL TKDRKRRSQD GCPDGCASLT
ATAPSPEVSA AATISLMTDE PGLDNPAYVS SVEDGQPAIS PVDSGRSNRT RARPFERSTI
RSRSFKKINR ALSVLRRTKS GSAVANHADQ GRENSENTTA PEVFPRLYHL IPDGEITSIK
INRVDPSESL SIRLVGGSET PLVHIIIQHI YRDGVIARDG RLLPGDIILK VNGMDISNVP
HNYAVRLLRQ PCQVLWLTVM REQKFHSRNN GQAPDAYGPR DDSFHVILNK SSPQEQLGIK
LVRKVDEPGV FIFNVLDGGV ADRHGQLEEN DRVLAINGHD LRYGSPESAA HLIQASERRV
HLVVSRRVRQ QSPDIFQEAG WNSNGSWSPR PGERSNTPKP LHPTITCHEK VVNIQKDPGE
SLGMTVAGGA SHREWDLPIY VISVEPGGVI SRDGRIKTGD ILLNVDGVEL TEVSRSEAVA
LLKRTSSSIV LKALEVKEYE PQEDCSSPAA LDSNHNMAPP SDWSPSWVMW LELPRCLYNC
KDIILRRNTA GSLGFCIVGG YEEYNGNKPF FIKSIVEGTP AYNDGRIRCG DILLAVNGRS
TSGMIHACLA RLLKELKGRI TLTIVSWPGT FL
//
