ID A0A2I2Z5J2_GORGO Unreviewed; 2737 AA.
AC A0A2I2Z5J2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Neurobeachin like 2 {ECO:0000313|Ensembl:ENSGGOP00000042508.1};
GN Name=NBEAL2 {ECO:0000313|Ensembl:ENSGGOP00000042508.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000042508.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000042508.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000042508.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000042508.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030021103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000064977.1; ENSGGOP00000042508.1; ENSGGOG00000009020.3.
DR GeneTree; ENSGT00940000158454; -.
DR Proteomes; UP000001519; Chromosome 3.
DR Bgee; ENSGGOG00000009020; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF111; NEUROBEACHIN-LIKE PROTEIN 2; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF16057; DUF4800; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 1898..2023
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2036..2328
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2481..2514
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2532..2573
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1281..1321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1347..1421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1310
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1347..1370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1387..1421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2737 AA; 300410 MW; 50A24989EA7C8601 CRC64;
LWALERAWQK DLGYLQQWLK AFVGAFKKSI SLSSLEPRRP EEAGAEVPLL PLDELHVLAE
QLHQADLEQA LLLLKLFIIL CRNLENIEAG RGQVLVPRVL ALLTKLVAEL KGCPPPQGQG
TQLENVALHA LLLCEGLFDP YQTWRRQRSG EVISSKEKSK YKFPPAALPQ EFSAFFQESL
QNADHLPPVL LLRLIHLFCA VLAGGKENGQ MAVSDGSVKG LLSVVRDWSR GPAPDPCLVP
LALEALVGAV HVLHASRAPP RGPELRALLE SYFHVLNADW PAGLSSGPEE ALVTLRVSML
DAIPMMLACE DRPVLQATFL SNNCFEHLTR LIQNSKLYLQ SRAPPEGDSD LATRLLTEPD
VQKVLDQDTD AIAVHVVRVL TCIMSDSPSA KEVFKERIGY PHLQEVLQSH GPPTHRLLQE
LLNMAVEGDH SMCPPPPIRN EQPVLVLAQW LPSLPTAELR LFLAQRLRWL CDSCPASRAT
CVQAGLVGCL LETLSTGLAL EARCQEQLLA LLQALGRVSI RPMELRHLLR PPPGLDSEPG
GAEAGKARHA GAVIRALSGM ARHQGPARAL RYFDLTPSMA GIMVPPVQRW PGPGFTFHAW
LCLHPMDTAP TPAPTRPLQR KQLYSFFSSS GSGFEAFFTA AGTLVVAVCT RKEYLTMSLP
EVSFADSAWH CVAIVHVPGR RPFSQNLVHV YKDGHLVKTA PLRCPSLSEP FSSCCIGSAG
YRTTTTTTGL PTPPVPATLA YTHPALTRSQ SVPASTGLGW GSGLVAPLQE GSIDSTLAGT
QDTRWGSPTS LEGELGAVAI FHEALQATAL RTLCTLGPNE TAPFKPEGEL HELSTRLLLH
YSPQACKNNI CLDLSPSHGL DGRLTGHRVE TWDVKDVVNC IGGMGALLPL LERVAAQPKE
AEAGPAETHD LVGPELTSGH NTQGLVLPLG KSSGKVLSRL VAMFVAVMAV QGRVAAEKLR
QQTAPVLSQV PSWAMDMNVL MSAQLLMEQV AAEGSGPLLY LLYQHLLFNF HLWTLSDFAV
RLGHIQYMSS IVREHRQKLR KKYGVQFILD ALRTHYSPQR ERPLAADDLR TVQTSLLGLA
REFLVRSLSA DDVQVTQTML SFLAATGDDG QVVGVLDLLL ALLHGSLAQE SLAVFLLEPG
NLEVLLALLV RPGSLPLLPD RVCKILRRLQ QNERLPERSR QRLRLRECGL QGLVACLPEG
TVSPQLCQGL YKLFLGADCL NLSDLLAVVQ LSLQADLSVR LDICRQLFHL IYRQPDVVRL
LARQAGWQDV LTRLYVLEAA TAGSPPPSSP ESPTSPKPAP PKPPTESPAE PSDVFLPSEA
PCPDPDGFYH ALSPFCTPFD LGLERSSVGS GNTAGGGGSS GTLTPASQPG TPSPLDGPRP
FPAAPGRHSS SLSNVLEDGS LPEPTISGDD TSNTSNPQQT SEEELCNLLT NVLFSVTWRG
VEGSDEAAWR ERGQVFSVLT QLGASATLVR PPDFIKRSLL EMMLESALTD IKEAPMGVLA
SLTQQALWLL RLLQDFLCAE GHGNQELWSE KLFEGVCSLL DRLGAWPHLA NGTADLREMA
QIGLRLVLGY ILLEDPQLHA QAYVRLHMLL QTAVPARREE ACYVLSKLEA ALGRALNISS
SESATDEAGP PPAAAAAAAA AERCSWLVPL VRTLLDRAYE PLGLQWGLPS LPPTNGSPTF
FEDFQAFCAT PEWRHFIDKQ VQPTMSQFEM DTYAKSHDLM SGFWNACYDM LMSGGQRRQR
ERAQSRRAFQ ELVLEPAQRR ARLEGLRYTA VLKQQATQHS TALLHWGALW CQLASPCGAW
ELRDTPTPRW KLSSAETYSR MRLKLVPNHH FDPHLEASAL RDNLGEVPLT PTEEASLPLA
VTKEAKVSTP PEELQEDQLG EDELAELETP MEAAELDEQR EKLVLSAECQ LVTVVAVVPG
LLEVTTQNVY FYDGSTERME TEEGIGYDFR RPLAQLREVH LRRFNLRRSA LELFFIDQAN
YFLNFPCKVG TTPVSSPSQT PRPQPGPIPP HTQVRNQVYS WLLRLRPPSQ GYLSSRSPQE
MLRASGLTQK WVQREISNFE YLMQLNTIAG RTYNDLSQYP VFPWVLQDYV SPTLDLSNPA
VFRDLSKPIG VVNPKHAQLV REKYESFEDP AGTIDKFHYG THYSNAAGVM HYLIRVEPFT
SLHVQLQSGR FDCSDRQFHS VAAAWQARLE SPADVKELIP EFFYFPDFLE NQNGFDLGCL
QLTNEKVGDV VLPPWASSPE DFIQQHRQAL ESEYVSTHLH EWIDLIFGYK QRGPAAEEAL
NVFYYCTYEG AVDLDHVTDE RERKALEGII SNFGQTPCQL LKEPHPTRLS AEEAAHRLAR
LDTNSPSIFQ HLDQLKAFFA EVVSDGVPLV LALVPHRQPH SFITQGSPDL LVTVSASGLL
GTHSWLPYDR NISNYFSFSK DPTMGSHKTQ RLLSGPWVPG SGVSGQALAV APDGKLLFSG
GHWDGSLRVT ALPRGKLLSQ LSRHLDVVTC LALDTCGIYL ISGSRDTTCM VWRLLHQGGL
SVGLAPKPVQ VLYGHGAAVS CVAISTELDM AVSGSEDGTV IIHTVRRGQF VAALRPLGAT
FPGPIFHLAL GSEGQIVVQS SAWERPGAQV TYSLHLYSVN GKLRASLPLA EQPTALTVTE
DFVLLGTAQC ALHILQLNTL LPAAPPLPMK VAIRSVAVTK ERSHVLVGLE DGKLIVVVAG
QPSEVRSSQF ARKLWRSSRR ISQVSSGETE YNPAEAR
//
