ID A0A2I2Z7Y7_GORGO Unreviewed; 253 AA.
AC A0A2I2Z7Y7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cellular communication network factor 6 {ECO:0000313|Ensembl:ENSGGOP00000043343.1};
GN Name=CCN6 {ECO:0000313|Ensembl:ENSGGOP00000043343.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000043343.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000043343.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000043343.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000043343.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030047322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2Z7Y7; -.
DR Ensembl; ENSGGOT00000065260.1; ENSGGOP00000043343.1; ENSGGOG00000004894.3.
DR GeneTree; ENSGT00940000160119; -.
DR Proteomes; UP000001519; Chromosome 6.
DR Bgee; ENSGGOG00000004894; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR PANTHER; PTHR11348:SF3; CELLULAR COMMUNICATION NETWORK FACTOR 6; 1.
DR PANTHER; PTHR11348; CONNECTIVE TISSUE GROWTH FACTOR-RELATED; 1.
DR Pfam; PF00219; IGFBP; 1.
DR SMART; SM00121; IB; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..253
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014128322"
FT DOMAIN 62..135
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
SQ SEQUENCE 253 AA; 27433 MW; E83A27D154938EDE CRC64;
MNKRRLLYPS GWLHGPSDMQ GLLFSTLLLA GLAQFCCRVQ GTGPLDTTPE GRPGEVSDAP
QRKQFCHWPC KCPHQKPRCP PGVSLVRDGC GCCKICAKQP GEICNEADLC DPHKGLYCDY
SVDRPRYETG VCAYLVAVGC EFNQVHYHNG QVFQPNPLFS CLCVSGAIGC TPLFIPKLAG
SHCSGAKGGK KSDQSNCSLE PLLQQLSTSY KTMPDVCQAS NLLPALRSLN CCLPSSLLKM
SQGPDSFITR SSQ
//
