ID A0A2I2Z8V6_GORGO Unreviewed; 630 AA.
AC A0A2I2Z8V6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Cytoplasmic dynein 1 intermediate chain 2 {ECO:0000256|ARBA:ARBA00040292};
DE AltName: Full=Cytoplasmic dynein intermediate chain 2 {ECO:0000256|ARBA:ARBA00042023};
DE AltName: Full=Dynein intermediate chain 2, cytosolic {ECO:0000256|ARBA:ARBA00042966};
GN Name=DYNC1I2 {ECO:0000313|Ensembl:ENSGGOP00000043526.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000043526.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000043526.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000043526.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000043526.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC {ECO:0000256|ARBA:ARBA00011059}.
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DR EMBL; CABD030017038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030017039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004032829.1; XM_004032781.2.
DR RefSeq; XP_004032832.1; XM_004032784.2.
DR AlphaFoldDB; A0A2I2Z8V6; -.
DR SMR; A0A2I2Z8V6; -.
DR Ensembl; ENSGGOT00000058254.1; ENSGGOP00000043526.1; ENSGGOG00000002696.3.
DR GeneID; 101142819; -.
DR KEGG; ggo:101142819; -.
DR CTD; 1781; -.
DR GeneTree; ENSGT00940000155442; -.
DR OrthoDB; 654577at2759; -.
DR Proteomes; UP000001519; Chromosome 2B.
DR Bgee; ENSGGOG00000002696; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR025956; DYNC1I1/DYNC1I2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR12442:SF37; CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2; 1.
DR PANTHER; PTHR12442; DYNEIN INTERMEDIATE CHAIN; 1.
DR Pfam; PF11540; Dynein_IC2; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..205
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 70485 MW; 5C3022F6F62D9C67 CRC64;
MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEAVAPVQEE SDLEKKRREA
EALLQSMGLT PESPIAEQPL RVVTADTCLF HYLVPPPMSP SSKSVSTPSE AGSQDSGDGA
VGSRRGPIKL GMAKITQVDF PPREIVTYTK ETQTPVMAQP KEDEEEDDDV VAPKPPIEPE
EEKTLKKDEE NDSKAPPHEL TEEEKQQILH SEEFLSFFDH STRIVERALS EQINIFFDYS
GRDLEDKEGE IQAGAKLSLN RQFFDERWSK HRVVSCLDWS SQYPELLVAS YNNNEDAPHE
PDGVALVWNM KYKKTTPEYV FHCQSAVMSA TFAKFHPNLV VGGTYSGQIV LWDNRSNKRT
PVQRTPLSAA AHTHPVYCVN VVGTQNAHNL ISISTDGKIC SWSLDMLSHP QDSMELVHKQ
SKAVAVTSMS FPVGDVNNFV VGSEEGSVYT ACRHGSKAGI SEMFEGHQGP ITGIHCHAAV
GAVDFSHLFV TSSFDWTVKL WTTKNNKPLY SFEDNADYVY DVMWSPTHPA LFACVDGMGR
LDLWNLNNDT EVPTASISVE GNPALNRVRW THSGREIAVG DSEGQIVIYD VGEQIAVPRN
DEWARFGRTL AEINANRADA EEEAATRIPA
//
