GenomeNet

Database: UniProt
Entry: A0A2I2ZAR0_GORGO
LinkDB: A0A2I2ZAR0_GORGO
Original site: A0A2I2ZAR0_GORGO 
ID   A0A2I2ZAR0_GORGO        Unreviewed;      4841 AA.
AC   A0A2I2ZAR0;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 6.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSGGOP00000044358};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000044358, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000044358, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000044358}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; CABD030095306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030095307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030095308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030095309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030095310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030095311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030095312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030095313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030095314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030095315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGGOT00000052977; ENSGGOP00000044358; ENSGGOG00000009119.
DR   GeneTree; ENSGT00940000155507; -.
DR   Proteomes; UP000001519; Chromosome 15.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4164   4188       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4395   4415       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4463   4482       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4581   4599       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4642   4663       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4722   4745       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       95    150       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      157    202       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      338    395       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      580    791       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1007   1203       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1249   1461       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3900   3935       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      454    474       {ECO:0000256|SAM:Coils}.
FT   COILED     3218   3238       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4841 AA;  549313 MW;  D0CC54B28AE34BF4 CRC64;
     MARRSEGGRL QLEDEVVLQC IATMHKEQRK FCLAAEGLGN RLCFLEPTSE AKYIPPDLCV
     CNFVLEQSLS VRALQEMLAN TGENGGEGAA QGGGHRTLLY GHAVLLRHSF SGMYLTCLTT
     SRSQTDKLAF DVGLREHATG EACWWTIHPA SKQRSEGEKV RIGDDLILVS VSSERYLHLS
     VSNGNIQVDA SFMQTLWNVH PTCSGSSIEE GYLLGGHVVR LFHGHDECLT IPSTDQNDSQ
     HRRIFYEAGG AGTRARSLWR VEPLRISWSG SNIRWGQAFR LRHLTTGHYL ALTEDQGLIL
     QDRAKSDTKS TAFSFRASKE LKEKLDSSHK RDIEGMGVPE IKYGDSVCFV QHIASGLWVT
     YKAQDAKTSR LGPLKRKVIL HQEGHMDDGL TLQRCQREES QAARIIRNTT ALFSQFVSGN
     NRTAAPITLP IEEVLQTLQD LIAYFQPPEE EMRHEDKQNK LRSLKNRQNL FKEEGMLALV
     LNCIDRLNIY NSVAHFAGIV REESGMAWKE ILNLLYKLLA ALIRGNRNNC AQFSNNLDWL
     ISKLDRLESS SGILEVLHCI LTESPEALNL IAEGHIKSII SLLDKHGRNH KVLDILCSLC
     LCNGVAVRAN QNLICDNLLP RRNLLLQTRL INDVTSIRPN IFLGVAEGSA QYKKWYFELI
     IDQVDPFLTA EPTHLRVGWA SSSGYAPYPG GGEGWGGNGV GDDLYSYGFD GLHLWSGRIP
     RAVASINQHL LRSDDVVSCC LDLGVPSISF RINGQPVQGM FENFNTDGLF FPVMSFSAGV
     KVRFLMGGRH GEFKFLPPSG YAPCYEALLP KEKMRLEPVK EYKRDADGIR DLLGTTQFLS
     QASFIPCPVD TSQVVLPPHL EKIRDRLAEN IHELWGMNKI ELGWTFGKIR DDNKRQHPCL
     VEFSKLPETE KNYNLQMSTE TLKTLLALGC HIAHVNPAAE EDLKKVKLPK NYMMSNGYKP
     APLDLSDVKL LPPQEILVDK LAENAHNVWA KDRIKQGWTY GIQQDLKNKR NPRLVPYALL
     DERTKKSNRD SLREAVRTFV GYGYNIEPSD QELADSAVEK VSIDKIRFFR VERSYAVRSG
     KWYFEFEVVT GGDMRVGWAR PGCRPDVELG ADDQAFVFEG NRGQRWHQGS GYFGRTWQPG
     DVVGCMINLD DASMIFTLNG ELLITNKGSE LAFADYEIEN GFVPICCLGL SQIGRMNLGT
     DASTFKFYTM CGLQEGFEPF AVNMNRDVAM WFSKRLPTFV NVPKDHPHIE VMRIDGTMDS
     PPCLKVTHKT FGTQNSNADM IYCRLSMPVE CHSSFSHSPC LDSEAFQKRK QMQEILSHTT
     TQCYYAIRIF AGQDPSCVWV GWVTPDYHLY SEKFDLNKNC TVTVTLGDER GRVHESVKRS
     NCYMVWGGDI VASSQRSNRS NVDLEIGCLV DLAMGMLSFS ANGKELGTCY QVEPNTKVFP
     AVFLQPTSTS LFQFELGKLK NAMPLSAAIF KSEEKNPVPQ CPPRLDVQTI QPVLWSRMPN
     SFLKVETERV SERHGWVVQC LEPLQMMALH IPEENRCVDI LELCEQEDLM RFHYHTLRLY
     SAVCALGNSR VAYALCSHVD LSQLFYAIDN KYLPGLLRSG FYDLLISIHL ANAKERKLMM
     KNEYIIPITS TTRNIRLFPD ESKRHGLPGV GLRTCLKPGF RFSTPCFVVT GEDHQKQSPE
     IPLESLRTKA LSMLTEAVQC SGAHIRDPVG GSVEFQFVPV LKLIGTLLVM GVFDDDDVRQ
     ILLLIDPSVF GEHSAGTEEG AEKEEVTQVE EKAVEAGEKA GKEAPVKGLL QTRLPESVKL
     QMCELLSYLC DCELQHRVEA IVAFGDIYVS KLQANQKFRY NELMQALNMS AALTARKTKE
     FRSPPQEQIN MLLNFQLGEN CPCPEEIREE LYDFHEDLLL HCGVPLEEEE EEEEDTSWTG
     KLCALVYKIK GPPKPEKEQP TEEEERCPTT LKELISQTMI CWAQEDQIQD SELVRMMFNL
     LRRQYDSIGE LLQALRKTYT ISHTSVSDTI NLLAALGQIR SLLSVRMGKE EELLMINGLG
     DIMNNKVFYQ HPNLMRVLGM HETVMEVMVN VLGTEKSQIA FPKMVASCCR FLCYFCRISR
     QNQKAMFEHL SYLLENSSVG LASPSMRGST PLDVAASSVM DNNELALSLE EPDLEKVVTY
     LAGCGLQSCP MLLAKGYPDV GWNPIEGERY LSFLRFAVFV NSESVEENAS VVVKLLIRRP
     ECFGPALRGE GGNGLLAAMQ GAIKISENPA LDLPSQGYKR EVSTEDDEEE EEIVHMGNAI
     MSFYSALIDL LGRCAPEMHL IQTGKGEAIR IRSILRSLVP TEDLVGIISI PLKLPSLNKD
     GSVSEPDMAA NFCPDHKAPM VLFLDRVYGI KDQTFLLHLL EVGFLPDLRA SASLDTVSLS
     TTEAALALNR YICSAVLPLL TRCAPLFAGT EHCTSLIDST LQTIYRLSKG RSLTKAQRDT
     IEECLLAICN HLRPSMLQQL LRRLVFDVPQ LNEYCKMPLK LLTNHYEQCW KYYCLPSGWG
     SYGLAVEEEL HLTEKLFWGI FDSLSHKKYD PDLFRMALPC LSAIAGALPP DYLDTRITAT
     LEKQISVDAD GNFDPKPINT MNLSLPEKLE YIVTKYAEHS HDKWACDKSQ SGWKYGISLD
     ENVKTHPLIR PFKTLTEKEK EIYRWPARES LKTMLAVGWT VERTKEGEAL VQQRENEKLR
     SVSQANQGNS YSPAPLDLSN VVLSRELQGM VEVVAENYHN IWAKKKKLEL ESKGGGSHPL
     LVPYDTLTAK EKFKDREKAQ DLFKFLQVNG VIVSRGMKDM ELDASSMEKR FAYKFLKKIL
     KYVDSAQEFI AHLEAIVSSG KTEKSPHDQE IKFFAKVLLP LVDQYFTNHC LYFLSSPLKP
     LSSSGYASHK EKEMVARLHL KDRLSGLRES QMIFFIPGSD STTMVSCLHI LAQTLDTRTV
     MKSGSELVKA GLRAFFENAA EDLEKTSENL KLGKFTHSRT QIKGVSQNIN YTTVALLPIL
     TSIFEHVTQH QFGMDLLLGD VQISCYHILC SLYSLGTGKN IYVERQRPAL GECLASLAAA
     IPVAFLEPTL NRYNPLSVFN TKTPRERSIL GMPDTVEDMC PDIPQLEGLM KEINDLAESG
     ARYTEMPHVI EVILPMLCNY LSYWWERGPE NLPPSTGPCC TKVTSEHLSL ILGNILKIIN
     NNLGIDEASW MKRIAVYAQP IISKARPDLL RSHFIPTLEK LKKKAVKTVQ EEEQLKADGK
     GDTQEAELLI LDEFAVLCRD LYAFYPMLIR YVDNNRSNWL KSPDADSDQL FRMVAEVFIL
     WCKSHNFKRE EQNFVIQNEI NNLAFLTGDS KSKMSKSGGQ DQERKKTKRR GDLYSIQTSL
     IVAALKKMLP IGLNMCTPGD QELISLAKSR YSHRDTDEEV REHLRNNLHL QEKSDDPAVK
     WQLNLYKDVL KSEEPFNPEK TVERVQRISA AVFHLEQVEQ PLRSKKAVWH KLLSKQRKRA
     VVACFRMAPL YNLPRHRSIN LFLHGYQRFW IETEEYSFEE KLVQDLAKSP KVEEEEEEET
     EKQPDPLHQI ILYFSRNALT ERRSEPPSCQ SGEDEEEDED KEKTFEEKEM EKQKTLYQQA
     RLHERGAAEM VLQMISASKG EMSPMVVETL KLGIAILNGG NAGVQQKMLD YLKEKKDAGF
     FQSLSGLMQS CSVLDLNAFE RQNKAEGLGM VTEEGTLIVR ERGKFQFLND EFTRDLFRFL
     QLLCEGHNSD FQNFLRTQMG NTTTVNVIIS TVDYLLRLQE SISDFYWYYS GKDIIDESGQ
     HNFSKALAVT KQIFNSLTEY IQGPCIGNQQ SLAHSRLWDA VVGFLHVFAN MQMKLSQDSS
     QIELLKELLD LLQDMVVMLL SLLEGNVVNG TIGKQMVDTL VESSTNVEMI LKFFDMFLKL
     KDLTSSDTFK EYDPDGKGII SKKEFQKAME GQKQYTQSEI DFLLSCAEAD ENDMFNYIDF
     VDRFHEPAKD IGFNVAVLLT NLSEHMPNDS RLKCLLDPAE SVLNYFEPYL GRIEIMGGAK
     KIERVYFEIS ESSRTQWEKP QVKESKRQFI FDVVNEGGEQ EKMELFVNFC EDTIFEMQLA
     SQISESDSAD RPEEEEEDED SSYVLEIAGE EEEDGSLEPA SAFAMACASV KRNVTDFLKR
     ATLKNLRKQY RNVKKMTAKE LVKVLFSFFW MLFVGLFQLL FTILGGIFQI LWSTVFGGGL
     VEGAKNIRVT KILGDMPDPT QFGIHDDTME AERAEVMEPG ITTELVHFIK GEKGDTDIMS
     DLFGLHPKKE GSLKHGPEVG LGDLSEIIGK NEPPTLQSTV QKKRKAQAAE MKAANEAEGK
     VESEKADINY SHCYEKEDKD KEEEQAEYLW TEVTKKKKRR CGQKVEKPEA FTANFFKGLE
     IYQTKLLHYL ARNFYNLRFL ALFVAFAINF ILLFYKVTEE PLEEETEDVA NLWNSFNDEE
     EEEAMVFFVL QESTGYMAPT LRALAIIHTI ISLVCVVGYY CLKVPLVVFK REKEIARKLE
     FDGLYITEQP SEDDIKGQWD LSLYPNLKRR WSLYYLYGAE RIAELLGLDK NALDFSPVEE
     TKAEAASLVS WLSSIDMKYH IWKLGVVFTD NSFLYLAWYT TMSVLGHYNN FFFAAHLLDI
     AMGFKTLRTI LSSVTHNGKQ LVLTVGLLAV VVYLYTVVAF NFFRKFYNKS EDDDEPDMKC
     DDMMTCYLFH MYVGVRAGGG IGDEIEDPAG DPYEMYRIVF DITFFFFVIV ILLAIIQGLI
     IDAFGELRDQ QEQVREDMET KCFICGIGND YFDTTPHGFE THTLQEHNLA NYLFFLMYLI
     NKDETEHTGQ ESYVWKMYQE RCWDFFPAGD CFRKQYEDQL G
//
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