ID A0A2I2ZBN8_GORGO Unreviewed; 762 AA.
AC A0A2I2ZBN8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 21 {ECO:0000256|ARBA:ARBA00020102};
DE AltName: Full=Coiled-coil domain-containing protein 128 {ECO:0000256|ARBA:ARBA00031617};
DE AltName: Full=KLRAQ motif-containing protein 1 {ECO:0000256|ARBA:ARBA00031361};
GN Name=PPP1R21 {ECO:0000313|Ensembl:ENSGGOP00000044435.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000044435.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000044435.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000044435.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000044435.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC Endosome {ECO:0000256|ARBA:ARBA00004177}.
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DR EMBL; CABD030012966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030012967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2ZBN8; -.
DR Ensembl; ENSGGOT00000047640.1; ENSGGOP00000044435.1; ENSGGOG00000016362.3.
DR GeneTree; ENSGT00390000006820; -.
DR Proteomes; UP000001519; Chromosome 2A.
DR Bgee; ENSGGOG00000016362; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR InterPro; IPR040024; PPP1R21.
DR InterPro; IPR049372; PPP1R21_C.
DR InterPro; IPR019343; PPP1R21_N.
DR InterPro; IPR019348; PPP1R21_six_helix.
DR PANTHER; PTHR21448:SF0; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21; 1.
DR PANTHER; PTHR21448; SMOOTH MUSCLE MYOSIN HEAVY CHAIN-RELATED; 1.
DR Pfam; PF10205; KLRAQ; 1.
DR Pfam; PF21636; PPP1R21_C; 1.
DR Pfam; PF10212; PPP1R21_helical; 1.
DR SMART; SM01254; KLRAQ; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 1..94
FT /note="Protein phosphatase 1 regulatory subunit 21 N-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM01254"
FT REGION 66..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 20..54
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 119..178
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 540..574
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 678..719
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 762 AA; 86305 MW; 5040144D8F62F671 CRC64;
MLRAQNQVLK KGVVDEQANS AALKEQLKMK DQSLRKLQQE MDSLTFRNLQ LAKRVELLQD
ELALSEPRGK KNKKSGESSS QLSQEQKSVF DEDLQKKIEE NERLHIQFFE ADEQHKHVEA
ELRSRLATLE TEAAQHQAVV DGLTRKYMET IEKLQNDKAK LEVKSQTLEK EAKECRLRTE
ECQLQLKTLH EDLSGRLEES LSIINEKVPF NDTKYSQYNP LNVPLHNRRH QLKMRDIAGQ
ALAFVQDLVT ALLNFHTYTE QRIQIFPVDS AIDTISPLNQ KFSQYLHENA SYVRPLEEGM
LHLFESITED TVTVLETTVK LKSFSEHLTS YICFLRKILP YQLKSLEEEC ESSLCTSALR
ARNLELSQDM KKMTAVFEKL QTYIALLALP STEPDGLLRT NYSSVLTNVG AALHGFHDVM
KDISKHYSQK ATIEHELPTA TQKLITTNDC ILSSVVALTN GAGKIASFFS NNLDYFIASL
SYGPKAASGF ISPLSAECML QYKKKAAAYM KSLRKPLLES VPYEEALANR RILLSSTESR
EGLAQQVQQS LEKISKLEQE KEHWMLEAQL AKIKLEKENQ RIADKLKSTG SAQLVGLAQE
NAAVSDTAGQ DEATAKAVLE PIQSTSLIGT LTRTSDSKVP DVESREDLIK NHYMARIVEL
TSQLQLADSK SVHFYAECRA LSKRLALAEK SKEALTEEMK LASQNISRLQ DELTTTKRSY
EDQLSMMSDH LCSMNETLSK QREEIDTLKM SSKGNSKKNK SR
//
