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Database: UniProt
Entry: A0A2I2ZE17_GORGO
LinkDB: A0A2I2ZE17_GORGO
Original site: A0A2I2ZE17_GORGO 
ID   A0A2I2ZE17_GORGO        Unreviewed;      4768 AA.
AC   A0A2I2ZE17;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 6.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSGGOP00000045245};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000045245, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000045245, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000045245}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; CABD030009618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030009627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGGOT00000058805; ENSGGOP00000045245; ENSGGOG00000012582.
DR   GeneTree; ENSGT00940000154906; -.
DR   Proteomes; UP000001519; Chromosome 1.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4081   4100       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4301   4321       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4375   4394       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4511   4532       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4569   4590       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4645   4668       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      111    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    218       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      226    281       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      287    344       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      352    409       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      600    810       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1026   1224       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3824   3859       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      473    493       {ECO:0000256|SAM:Coils}.
FT   COILED     2880   2900       {ECO:0000256|SAM:Coils}.
FT   COILED     3145   3165       {ECO:0000256|SAM:Coils}.
FT   COILED     4213   4246       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4768 AA;  541826 MW;  4B49A14C1AC57547 CRC64;
     MIWTVQSCHV SLIFPSLSPP LQDDEVVLQC TATIHKEQQK LCLAAEGFGN RLCFLESTSN
     SKNVPPDLSI CTFVLEQSLS VRALQEMLAN TVEKSEGQVD VEKWTAQGGG HRTLLYGHAI
     LLRHSYSGMY LCCLSTSRSS TDKLAFDVGL QEDTTGEACW WTIHPASKQR SEGEKVRVGD
     DLILVSVSSE RYLHLSYGNG SLHVDAAFQQ TLWSVAPISS GSEAAQGYLI GGDVLRLLHG
     HMDECLTVPS GEHGEEQRRT VHYEGGAVSV HARSLWRLET LRVAWSGSHI RWGQPFRLRH
     VTTGKYLSLM EDKNLLLMDK EKADVKSTAF TFRSSKEKLD VGVRKEVDGM GTSEIKYGDS
     VCYIQHVDTG LWLTYQSVDV KSVRMGSIQR KAIMHHEGHM DDGISLSRSQ HEESRTARVI
     RSTVFLFNRF IRGLDALSKK AKASTVDLPI ESVSLSLQDL IGYFHPPDEH LEHEDKQNRL
     RALKNRQNLF QEEGMINLVL ECIDRLHVYS SAAHFADVAG REAGESWKSI LNSLYELLAA
     LIRGNRKNCA QFSGSLDWLI SRLERLEASS GILEVLHCVL VESPEALNII KEGHIKSIIS
     LLDKHGRNHK VLDVLCSLCV CHGVAVRSNQ HLICDNLLPG RDLLLQTRLV NHVSSMRPNI
     FLGVSEGSAQ YKKWYYELMV DHTEPFVTAE ATHLRVGWAS TEGYSPYPGG GEEWGGNGVG
     DDLFSYGFDG LHLWSGCIAR TVSSPNQHLL RTDDVISCCL DLSAPSISFR INGQPVQGMF
     ENFNIDGLFF PVVSFSAGIK VRFLLGGRHG EFKFLPPPGY APCYEAVLPK EKLKVEHSRE
     YKQERTYTRD LLGPTVSLTQ AAFTPIPVDT SQIVLPPHLE RIREKLAENI HELWVMNKIE
     LGWQYGPVRD DNKRQHPCLV EFSKLPEQER NYNLQMSLET LKTLLALGCH VGISDEHAED
     KVKKMKLPKN YQLTSGYKPA PMDLSFIKLT PSQEAMVDKL AENAHNVWAR DRIRQGWTYG
     IQQDVKNRRN PRLVPYTLLD DRTKKSNKDS LREAVRTLLG YGYNLEAPDQ DHAARAEVCS
     GTGERFRIFR AEKTYAVKAG RWYFEFETVT AGDMRVGWSR PGCQPDQELG SDERAFAFDG
     FKAQRWHQGN EHYGRSWQAG DVVGCMVDMN EHTMMFTLNG EILLDDSGSE LAFKDFDVGD
     GKSTMFSTLM CLNSRRYHYS QLPKPNNVLQ RFLFCLVLLC QYLVLLSSQY YYSVRIFPGQ
     EPANVWVGWI TSDFHQYDTG FDLDRVRTVT VTLGDEKGKV HESIKRSNCY MVCAGESMSP
     GQGRNNNGLE IGCVVDAASG LLTFIANGKE LSTYYQVEPS TKLFPAVFAQ ATSPNVFQFE
     LGRIKNVMPL SAGLFKSEHK NPVPQCPPRL HVQFLSHVLW SRMPNQFLKV DVSRISERQG
     WLVQCLDPLQ FMSLHIPEEN RSVDILELTE QEELLKFHYH TLRLYSAVCA LGNHRVAHAL
     CSHVDEPQLL YAIENKYMPG LLRAGYYDLL IDIHLSSYAT ARLMMNNEYI VPMTEETKSI
     TLFPDENKKH GLPGIGLSTS LRPRMQFSSP SFVSISNECY QYSPEFPLDI LKSKTIQMLT
     EAVKEGSLHA RDPVGGTTEF LFVPLIKLFY TLLIMGIFHN EDLKHILQLI EPSVFKEAAT
     PEEESDTLEK ELSVDDAKLQ GAGEEEAKGG KRPKEGLLQM KLPEPVKLQM CLLLQYLCDC
     QVRHRIEAIV AFSDDFVAKL QDNQRFRYNE VMQALNMSAA LTARKTKEFR SPPQEQINML
     LNFKDDKSEC PCPEEIRDQL LDFHEDLMTH CGIELDEDGS LDGNSDLTIR GRLLSLVEKV
     TYLKKKQAEK PVESDSKKSS TLQQLISETM VRWAQESVIE DPELVRAMFV LLHRQYDGIG
     GLVRALPKTY TINGVSVEDT INLLASLGQI RSLLSVRMGK EEEKLMIRGL GDIMNNKVFY
     QHPNLMRALG MHETVMEVMV NVLGGGESKE ITFPKMVANC CRFLCYFCRI SRQNQKAMFD
     HLSYLLENSS VGLASPAMRG STPLDVAAAS VMDNNELALA LREPDLEKVV RYLAGCGLQS
     CQMLVSKGYP DIGWNPVEGE RYLDFLRFAV FCNGESVEEN ANVVVRLLIR RPECFGPALR
     GEGGNGLLAA MEEAIKIAED PSRDGPSPNS GSSKTLDTEE EEDDTIHMGN AIMTFYSALI
     DLLGRCAPEM HLIHAGKGEA IRIRSILRSL IPLGDLVGVI SIAFQMPTIA KDGNVVEPDM
     SAGFCPDHKA AMVLFLDRVY GIEVQDFLLH LLEVGFLPDL RAAASLDTAA LSATDMALAL
     NRYLCTAVLP LLTRCAPLFA GTEHHASLID SLLHTVYRLS KGCSLTKAQR DSIEVCLLSI
     CGQLRPSMMQ HLLRRLVFDV PLLNEHAKMP LKLLTNHYER CWKYYCLPGG WGNFGAASEE
     ELHLSRKLFW GIFDALSQKK YEQELFKLAL PCLSAVAGAL PPDYMESNYV SMMEKQSSMD
     SEGNFNPQPV DTSNITIPEK LEYFINKYAE HSHDKWSMDK LANGWIYGEI YSDSSKVQPL
     MKPYKLLSEK EKEIYRWPIK ESLKTMLAWG WRIERTREGD SMALYNRTRR ISQTSQVSVD
     AAHGYSPRAI DMSNVTLSRD LHAMAEMMAE NYHNIWAKKK KMELESKGGG NHPLLVPYDT
     LTAKEKAKDR EKAQDILKFL QINGYAVSRG FKDLELDTPS IEKRFAYSFL QQLIRYVDEA
     HQYILEFDGG SRGKGEHFPY EQEIKFFAKV VLPLIDQYFK NHRLYFLSAA SRPLCSGGHA
     SNKEKEMNIE KFSGQFIQHF VSSLGNDATS IVNCLHILGQ TLDARTVMKT GLESVKSALR
     AFLDNAAEDL EKTMENLKQG QFTHTRNQPK GVTQIINYTT VALLPMLSSL FEHIGQHQFG
     EDLILEDVQV SCYRILTSLY ALGTSKSIYV ERQRSALGEC LAAFAGAFPV AFLETHLDKH
     NIYSIYNTKS SRERAALSLP TNVEDVCPNI PSLEKLMEEI VELAESGIRY TQMPHVMEVI
     LPMLCSYMSR WWEHGPENNP ERAEMCCTAL NSEHMNTLLG NILKIIYNNL GIDEGAWMKR
     LAVFSQPIIN KVKPQLLKTH FLPLMEKLKK KAATVVSEED HLKAEARGDM SEAELLILDE
     FTTLARDLYK YLYPFLIILI YQINTYLCKN LQVLLVLTEI SFATSQNFKR EEQNFVVQNE
     INNMSFLITD TKSKMSKAAV SDQERKKMKR KGDRYSMQTS LIVAALKRLL PIGLNICAPG
     DQELIALAKN RFSLKDTEDE VRDIIRSNIH LQGKLEDPAI RWQMALYKDL PNRTDDTSDP
     EKTVERVLDI ANVLFHLEQK SKRVGRRHYC LGSTVEHPQR SKKAVWHKLL SKQRKRAVVA
     CFRMAPLYNL PRHRAVNLFL QGYEKSWIET EEHYFEDKLI EDLAKPGAEP PEEDEGTKRV
     DPLHQLILLF SRTALTEKCC HDEEDDDGEE EVKSFEEKEM EKQKLLYQQA RLHDRGAAEM
     VLQTISASKG ETGPMVAATL KLGIAILNGG NSTVQQKMLD YLKEKKDVGF FQSLAGLMQS
     CSVLDLNAFE RQNKAEGLGM VTEEGSGEKV LQDDEFTCDL FRFLQLLCEG HNSDFQNYLR
     TQTGNNTTVN IIISTVDYLL RVQESISDFY WYYSGKDVID EQGQRNFSKA IQVAKQVFNT
     LTEYIQGPCT GNQQSLAHSR LWDAVVGFLH VFAHMQMKLS QDSSQIELLK ELMDLQKDMV
     VMLLSMLEGN VVNGTIGKQM VDMLVESSNN VEMILKFFDM FLKLKDLTSS DTFKEYDPDG
     KGVISKRDFH KAMESHKHYT QSETEFLLSC AETDENETLD YEEFVKRFHE PAKDIGFNVA
     VLLTNLSEHM PNDTRLQTFL ELAESVLNYF QPFLGRIEIM GSAKRIERVY FEISESSRTQ
     WEKPQVKESK RQFIFDVVNE GGEKEKMELF VNFCEDTIFE MQLAAQISES DLNERSANKE
     ESEKERPEEQ GPRMAFFSIL TVKSALFALR YNILTLMRML SLKSLKKQMK KVKKMTVKDM
     VTAFFSSYWS IFMTLLHFVA SVFRGFFRII CSLLLGGSLV EGAKKIKVAE LLANMPDPTQ
     DEVRGDGEEG ERKPLEAALP SEDLTDLKEL TEESDLLSDI FGLDLKREGG QYKLIPHNPN
     AGLSDLMSNP VPMPEVQEKF QEQKAKEEEK EEKEETKSEP EKAEGEDGEK EEKAKEDKGK
     QKLRQLHTHR YGEPEVPESA FWKKIIAYQQ KLLNYFARNF YNMRMLALFV AFAINFILLF
     YKVSTSSVVE GKELPTRSSS ENAKVTSLDS SSHRIIAVHY VLEESSGYME PTLRILAILH
     TVISFFCIIG YYCLKVPLVI FKREKEVARK LEFDGLYITE QPSEDDIKGQ WDRLVINTQS
     FPNNYWDKFV KRKVMDKYGE FYGRDRISEL LGMDKAALDF SDAREKKKPK KDSSLSAVLN
     SIDVKYQMWK LGVVFTDNSF LYLAWYMTMS VLGHYNNFFF AAHLLDIAMG FKTLRTILSS
     VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF RKFYNKSEDG DTPDMKCDDM LTCYMFHMYV
     GVRAGGGIGD EIEDPAGDEY EIYRIIFDIT FFFFVIVILL AIIQGLIIDA FGELRDQQEQ
     VKEDMETKCF ICGIGNDYFD TVPHGFETHT LQEHNLANYL FFLMYLINKD ETEHTGQESY
     VWKMYQERCW EFFPAGDCFR KQYEDQLN
//
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