ID A0A2I2ZEG8_GORGO Unreviewed; 553 AA.
AC A0A2I2ZEG8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=DENN domain containing 1A {ECO:0000313|Ensembl:ENSGGOP00000045476.1};
GN Name=DENND1A {ECO:0000313|Ensembl:ENSGGOP00000045476.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000045476.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000045476.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000045476.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000045476.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030066660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2ZEG8; -.
DR Ensembl; ENSGGOT00000062730.1; ENSGGOP00000045476.1; ENSGGOG00000016611.3.
DR GeneTree; ENSGT00940000156261; -.
DR Proteomes; UP000001519; Chromosome 9.
DR Bgee; ENSGGOG00000016611; Expressed in prefrontal cortex and 5 other cell types or tissues.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 6.10.140.1000; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR040032; DENND1A/B/C.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR13196; DENN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR13196:SF22; DENN DOMAIN-CONTAINING PROTEIN 1A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 7..372
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 447..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 62716 MW; 72CBABDA88E19E12 CRC64;
QNPETTFEVY VEVAYPRTGG TLSDPEVQRQ FPEDYSDQEV LQTLTKFCFP FYVDSLTVSQ
VGQNFTFVLT DIDSKQRFGF CRLSSGAKSC FCILSYLPWF EVFYKLLNIL ADYTTKRQEN
QWNELLETLH KLPIPDPGVS VHLSVHSYFT VPDTRELPSI PENRNLTEYF VAVDVNNMLH
LYASMLYERR ILIICSKLST LTACIHGSAA MLYPMYWQHV YIPVLPPHLL DYCCAPMPYL
IGIHLSLMEK VRNMALDDVV ILNVDTNTLE TPFDDLQSLP NDVISSLKNR LKKVSTTTGD
GVARAFLKAQ AAFFGSYRNA LKIEPEEPIT FCEEAFVSHY RSGAMRQFLQ NATQLQLFKQ
FIDGRLDLLN SGEGFSDVFE EEINMGEYAG SDKLYHQWLS TVRKGSGAIL NTVKTKANPA
MKTVYKFAKD HAKMGIKEVK NRLKQKDIAE NGCAPTPEEQ LPKTAPSPLV EAKDPKLRED
RRPITVHFGQ VRPPRPHVVK RPKSNIAVEG RRTSVPSPEQ NTIATPATLH ILQKSITHFA
AKFPTRGWTS SSH
//
