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Database: UniProt
Entry: A0A2I2ZF77_GORGO
LinkDB: A0A2I2ZF77_GORGO
Original site: A0A2I2ZF77_GORGO 
ID   A0A2I2ZF77_GORGO        Unreviewed;      2658 AA.
AC   A0A2I2ZF77;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 5.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 3 {ECO:0000313|Ensembl:ENSGGOP00000045717};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000045717, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000045717, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000045717}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
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DR   EMBL; CABD030044358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030044359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030044360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030044361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030044362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGGOT00000063232; ENSGGOP00000045717; ENSGGOG00000016235.
DR   GeneTree; ENSGT00940000157078; -.
DR   Proteomes; UP000001519; Chromosome 6.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2188   2213       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2225   2243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2255   2275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2311   2336       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2356   2378       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2485   2508       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      178    228       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      236    292       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      299    376       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      382    438       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       90    110       {ECO:0000256|SAM:Coils}.
FT   COILED     2616   2643       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2658 AA;  303036 MW;  642E6CE0F0F9A744 CRC64;
     MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC
     PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQSCPFL RRAWRCDDKR
     VVVGDKVILN PVNAGQPLHA SNYELSDNAG CKEVNSVNCN TSWKINLFMQ FRDHLEEVLK
     GGDVVRLFHA EQEKFLTCDE YKGKLQVFLR TTLRQSATSA TSSNALWEVE VVHHDPCRGG
     AGHWNGLYRF KHLATGNYLA AEENPSYKGD ASDPKAAGMG AQGRTGRRNA GEKIKYRLVA
     VPHGNDIASL FELDPTTLQK TDSFVPRNSY VRLRHLCTNT WIQSTNVPID IEEERPIRLM
     LGTCPTKEDK EAFAIVSVPV SEIRDLDFAN DASSMLASAV EKLNEGFISQ NDRRFVIQLL
     EDLVFFVSDV PNNGQNVLDI MVTKPNRERQ KLMREQNILK QIFGILKAPF REKGGEGPLV
     RLEELSDQKN APYQHMFRLC YRVLRHSQED YRKNQEHIAK QFGMMQSQIG YDILAEDTIT
     ALLHNNRKLL EKHITKTEVE TFVSLVRKNR EPRFLDYLSD LCVSNHIAIP VTQELICKCV
     LDPKNSDILI RTELRPVKEM AQSHEYLSIE YSEEEVWLTW TDKNNEHHEK SVRQLAQEAR
     AGNAHDENVL SYYRYQLKLF ARMCLDRQYL AIDEISQQLG VDLIFLCMAD EMLPFDLRAS
     FCHLMLHVHV DRDPQELVTP VKFARLWTEI PTAITIKDYD SNLNASRDDK KNKFANTMEF
     VEDYLNNVVS EAVPFANEEK NKLTFEVVSL AHNLIYFGFY SFSELLRLTR TLLGIIDCAY
     EDPGGENVRQ SIQGVGHMMS TMVLSRKQSV FSAPSLSAGA SAAEPLDRSK FEENEDIVVM
     ETKLKILEIL QFILNVRLDY RISYLLSVFK KEFVEVFPMQ DSGADGTAPA FDSTSKPLPC
     LQAEAVKTSS MLEVDDEGGR MFLRVLIHLT MHDYAPLVSG ALQLLFKHFS QRQEAMHTFK
     QVQLLISAQD VENYKVIKSE LDRLRTMVEK SELWVDKKGS GKGEEVEAGA AKDKKERPTD
     EEGFLHPPGE KSSENYQIVK GILERLNKMC GVGEQMRKKQ QRLLKNMDAH KVMLDLLQIP
     YDKGDAKMME ILRYTHQFLQ KFCAGNPGNQ ALLHKHLHLF LTPGLLEAET MQHIFLNNYQ
     LCSEISEPVL QHFVHLLATH GRHVQYLDFL HTVIKAEGKY VKKCQDMIMT ELTNAGDDVV
     VFYNDKASLA HLLDMMKAAR DGVEDHSPLM YHISLVDLLA ACAEGKNVYT EIKCTSLLPL
     EDVVSVVTHE DCITEVKMAY VNFVNHCYVD TEVEMKEIYT SNHIWTLFEN FTLDMARVCS
     KREKRVADPT LEKYVLSVVL DTINAFFSSP FSENSTSLQT HQTIVVQLLQ STTRLLECPW
     LQQQHKGSVE ACIRTLAMVA KGRAILLPMD LDAHISSMLS SGASCAAAAQ RNASSYKATT
     RAFPRVTPTA NQWDYKNIIE KLQDIITALE ERLKPLVQAE LSVLVDVLHW PELLFLEGSE
     AYQRCESGGF LSKLIQHTKD LMESEEKLCI KVLRTLQQML LKKTKYGDRG NQLRKMLLQN
     YLQNRKSTSR GDLLDPIGTG LDPDWSAIAA TQCRLDKEGA TKLVCDLITS TKNEKIFQES
     IGLAIHLLDG GNTEIQKSFH NLMMSDKKSE RFFKVLHDRM KRAQQETKST VAVNMNDLGS
     QPREDREPVD PTTKGRVASF SIPGSSSRYL LGPSLRRGHE VSERVQSSEM GTSVLIMQPI
     LRFLQLLCEN HNRDLQNFLR CQNNKTNYNL VCETLQFLDI MCGSTTGGLG LLGLYINEDN
     VGLVIQTLET LTEYCQGPCH ENQTCIVTHE SNGIDIITAL ILNDISPLCK YRMDLVLQLK
     DNASKLLLAL MESRHDSENA ERILISLRPQ ELVDVIKKAY LQEEERENSE VSPREVGHNI
     YILALQLSRH NKQLQHLLKP VKRIQEEEAE GISSMLSLNN KQLSQMLKSS VPAQEEEEDP
     LAYYENHTSQ IEIVRQDRSM EQIVFPVPGI CQFLTEETKH RLFTTTEQDE QGSKVSDFFD
     QSSFLHNEME WQRKLRSMPL IYWFSRRMTL WGSISFNLAV FINIIIAFFY PYMEGASTGV
     LDSPLISLLF WILICFSITA LFTKRYSIRP LIVALILRSI YYLGIGPTLN ILGALNLTNK
     IVFVVSFVGN RGTFIRGYKA MVMDMEFLYH VGYILTSVLG LFAHELFYSI LLFDLIYREE
     TLFNVIKSVT RNGRSILLTA LLALILVYLF SIVGFLFLKD DFILEVDRLP NNHSTASPLG
     MPHGAAAFVD TCSGDKMDCV SGVSVPEVLE EDRELDSTER ACDTLLMCIV TVMNHGLRNG
     GGVGDILRKP SKDESLFPAR VVYDLLFFFI VIIIVLNLIF GVIIDTFADL RSEKQKKEEI
     LKTTCFICGL ERDKFDNKTV SFEEHIKLEH NMWNYLYFIV LVRVKNKTDY TGPESYVAQM
     IKNKNLDWFP RMRAMSLVSN EGEGEQNEIR ILQDKLNSTM KLVSHLTAQL NELKEQMTEQ
     RKRRQRLGFV DVQNCISR
//
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