ID A0A2I2ZFH6_GORGO Unreviewed; 1178 AA.
AC A0A2I2ZFH6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Astrotactin 2 {ECO:0000313|Ensembl:ENSGGOP00000045903.1};
GN Name=ASTN2 {ECO:0000313|Ensembl:ENSGGOP00000045903.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000045903.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000045903.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000045903.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000045903.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030066036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066044; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2ZFH6; -.
DR STRING; 9593.ENSGGOP00000045903; -.
DR Ensembl; ENSGGOT00000066314.1; ENSGGOP00000045903.1; ENSGGOG00000038795.1.
DR GeneTree; ENSGT00390000003140; -.
DR InParanoid; A0A2I2ZFH6; -.
DR OMA; CHEGFAP; -.
DR Proteomes; UP000001519; Chromosome 9.
DR Bgee; ENSGGOG00000038795; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0060187; C:cell pole; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0043533; F:inositol 1,3,4,5 tetrakisphosphate binding; IBA:GO_Central.
DR GO; GO:0048105; P:establishment of body hair planar orientation; IEA:Ensembl.
DR GO; GO:2000009; P:negative regulation of protein localization to cell surface; IEA:Ensembl.
DR GO; GO:0007158; P:neuron cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0001764; P:neuron migration; IBA:GO_Central.
DR GO; GO:0034394; P:protein localization to cell surface; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR040685; Annexin-like.
DR InterPro; IPR045574; ASTN1_2_Fn3.
DR InterPro; IPR045575; ASTN_1_2_N.
DR InterPro; IPR040510; ASTN_2_hairpin.
DR InterPro; IPR026995; Astrotactin.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR020864; MACPF.
DR PANTHER; PTHR16592; -; 1.
DR PANTHER; PTHR16592:SF2; ASTROTACTIN-2; 1.
DR Pfam; PF18411; Annexin_2; 1.
DR Pfam; PF19743; ASTN1_2_fn3; 1.
DR Pfam; PF19441; ASTN_1_2_N; 2.
DR Pfam; PF18577; ASTN_2_hairpin; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 99..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 690..874
FT /note="MACPF"
FT /evidence="ECO:0000259|SMART:SM00457"
FT REGION 191..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1178 AA; 131833 MW; 16279E370465E19D CRC64;
GSPGSAGTTA ESRLLLFVRN ELPGRIAVQD DLDNTELPFF TLEMSGTAAD ISLVHWRQQW
LENGTLYFHV SMSSSGQLAQ ATTPTLQEPS EIVEEQMHIL HISVMGGLIA LLLLLLVFTV
ALYAQRRWQK RRRIPQKSAS TEATHEIHYI PSVLLGPQAR ESFRSSRLQT HNSVIGVPIR
ETPILDDYDC EEDEEPPRRA NHVSREDEFG SQVTHTLDSL GHPGEEKVDF EKKAAAEATQ
ETVESLMQKF KESFRANTPI EIGQLQPPLR STSAGKRKRR SKSRGGISFG RAKGTSGSEA
DDETQLTFYT EQYRSRRRSK GLLKSPVNKT ALTLIAVSSC ILAMVCGSQM SCPLTVKVTL
HVPEHFIADG ECSCHEGYAP DPVHRHLCVR SDWGQSEGPW PYTTLERGYD LVTGEQAPEK
ILRSTFSLGQ GLWLPVSKSF VVPPVELSIN PLASCKTDVL VTEDPADVRE EAMLSTYFET
INDLLSSFGP VRDCSRNNGG CTRNFKCVSD RQVDSSGCVC PEELKPMKDG SGCYDHSKGI
DCSDGFNGGC EQLCLQQTLP LPYDATSSTI FMFCGCVEEY KLAPDGKSCL MLSDVCEGPK
CLKPDSKFND TLFGEMLHGY NNRTQHVNQG QVFQMTFREN NFIKDFPQLA DGLLVIPLPV
EEQCRGVLSE PLPDLQLLTG DIRYDEAMGY PMVQQWRVRS NLYRVKLSTI TLSAGFTNVL
KILTKESSRE ELLSFIQHYG SHYIAEALYG SELTCIIHFP SKKVQQQLWL QYQKETTELG
SKKELKSMPF ITYLSGLLTA QMLSDDQLIS GVEIRCEEKG RCPSTCHLCR RPGKEQLSPT
PVLLEINRVV PLYTLIQDNG TKEAFKSALM SSYWCSGKGD VIDDWCRCDL SAFDASGLPN
CSPLPQPVLR LSPTVEPSST VVSLEWVDVQ PAIGTKVSDY ILQHKKVDEY TDTDLYTGEF
LSFADDLLSG LGTSCVAAGR SHGEVPEVSI YSVIFKCLEP DGLYKFTLYA VDTRGRHSEL
STVTLRTACP LVDDNKAEEI ADKIYNLYNG YTSGKEQQMA YNTLMEVSAS MLFRVQHHYN
SHYEKFGDFV WRSEDELGPR KAHLILRRLE RVSSHCSSLL RSAYIQSRVE TVPYLFCRSE
EVRPAGMVWY SILKDTKITC EEKMVSMARN TYGESKGR
//
