ID A0A2I2ZGK1_GORGO Unreviewed; 2042 AA.
AC A0A2I2ZGK1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Dedicator of cytokinesis 7 {ECO:0000313|Ensembl:ENSGGOP00000046212.1};
GN Name=DOCK7 {ECO:0000313|Ensembl:ENSGGOP00000046212.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000046212.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000046212.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000046212.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000046212.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; CABD030003588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030003589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030003590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030003591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030003592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030003593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030003594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030003595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000049031.1; ENSGGOP00000046212.1; ENSGGOG00000025768.2.
DR GeneTree; ENSGT00940000155661; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000025768; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR CDD; cd11703; DHR2_DOCK7; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF78; DEDICATOR OF CYTOKINESIS PROTEIN 7; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..2042
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014171309"
FT DOMAIN 496..662
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1582..2016
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 74..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2042 AA; 232074 MW; 8BD35994E4036A87 CRC64;
IYLFILFYFF ETETVAAEVR KQISGQYSGS PQLLKNLNIV GNISHHTTVN CIRSYTEDWA
IVIRKYHKLG TGFNPNTLDK QKERQKGLPK QVFESDEAPD GNNYQDDQDD LKRRSMSIDD
TPRGSWACSI FDLKNSLPDA LLPNLLDRTP NEEIDRQNDD QRKSNRHKEL FALHPSPDEE
EPIERLSVPD IPKEHFGQRL LVKCLSLKFE IEIEPIFASL ALYDVKEKKK ISENFYFDLN
SEQMKGLLRP HVPPAAITTL ARSAIFSITY PSQDVFLVIK LEKVLQQGDI GECAEPYMIF
KEADATKNKE KLEKLKSQAD QFCQRLGKYR MPFAWTAIHL MNIVSSAGSL ERDSTEVEIS
TGERKGSWSE RRNSSIVGRR SLERTTSGDD ACNLTSFRPA TLTVTNFFKQ EGDRLSDEDL
YKFLADMRRP SSVLRRLRPI TAQLKIDISP APENPHYCLT PELLQVKLYP DSRVRPTREI
LEFPAKDVYV PNTTYRNLLY IYPQSLNFAN RQGSARNITV KVQFMYGEDP SNAMPVIFGK
SSCSEFSKEA YTAVVYHNRS PDFHEEIKVK LPATLTDHHH LLFTFYHVSC QQKQNTPLET
PVGYTWIPML QNGRLKTGQF CLPVSLEKPP QAYSVLSPEV PLPGMKWVDN HKGVFNVEVV
AVSSIHTQDP YLDKFFALVN ALDEHLFPVR IGDMRIMENN LENELKSSIS ALNSSQLEPV
VRFLHLLLDK LILLVIRPPV IAGQIVNLGQ ASFEAMASII NRLHKNLEGN HDQHGRNSLL
ASYIHYVFRL PNTYPNSSSP GPGGLGGSVH YATMARSAVR PASLNLNRSR SLSNSNPDIS
GTPTSPDDEV RSIIGSKAMD RSCNRMSSHT ETSSFLQTLT GRLPTKKLFH EELALQWVVC
SGSVRESALQ QAWFFFELMV KSMVHHLYFN DKLEAPRKSR FPERFMDDIA ALVSTIASDI
VSRFQKDTEM VERLNTSLAF FLNDLLSVMD RGFVFSLIKS CYKQVSSKLY SLPNPSVLVS
LRLDFLRIIC SHEHYVTLNL PCSLLTPPAS PSPSVSSATS QSSGFSTNVQ DQKIANMFEL
SVPFRQQHYL AGLVLTELAV ILDPDAEGLF GLHKKVINMV HNLLSSHDSD PRYSDPQIKA
RVAMLYLPLI GIIMETVPQL YDFTETHNQR GRPICIATDD YESESGSMIS QTVAMAIAGT
SVPQLTRPGS FLLTSTSGRQ HTTFSAESSR SLLICLLWVL KNADETVLQK WFTDLSVLQL
NRLLDLLYLC VSCFEYKGKK VFERMNSLTF KKSKDMRAKL EEAILGSIGA RQEMVRRSRG
QLGTYTIASP PERSPSGSAF GSQENLRWRK DMTHWRQNTE KLDKSRAEIE HEALIDGNLA
TEANLIILDT LEIVVQTVSV TESKESILGG VLKVLLHSMA CNQSAVYLQH CFATQRALVS
KFPELLFEEE TEQCADLCLR LLRHCSSSIG TIRSHASASL YLLMRQNFEI GNNFARVKMQ
VTMSLSSLVG TSQNFNEEFL RRSLKTILTY AEEDLELRET TFPDQVQDLV FNLHMILSDT
VKMKEHQEDP EMLIDLMYRI AKGYQTSPDL RLTWLQNMAG KHSERSNHAE AAQCLVHSAA
LVAEYLSMLE DRKYLPVGCV TFQNISSNVL EESAVSDDVV SPDEEGICSG KYFTESGLVG
LLEQAAASFS MAGMYEAVNE VYKVLIPIHE ANRDAKKLST IHGKLQEAFS KIVHQDGKRM
FGTYFRVGFY GTKFGDLDEQ EFVYKEPAIT KLAEISHRLE GFYGERFGED VVEVIKDSNP
VDKCKLDPNK AYIQITYVEP YFDTYEMKDR ITYFDKNYNL RRFMYCTPFT LDGRAHGELH
EQFKRKTILT TSHAFPYIKT RVNVTHKEEI ILTPIEVAIE DMQKKTQELA FATHQDPADP
KMLQMVLQGS VGTTVNQGPL EVAQVFLSEI PSDPKLFRHH NKLRLCFKDF TKRCEDALRK
NKSLIGPDQK EYQRELERNY HRLKEALQPL INRKIPQLYK AVLPVTCHRD SFSRMSLRKM
DL
//
