ID A0A2I2ZGK4_GORGO Unreviewed; 817 AA.
AC A0A2I2ZGK4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=DCLK3 {ECO:0000313|Ensembl:ENSGGOP00000046395.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000046395.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000046395.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000046395.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000046395.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030020746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2ZGK4; -.
DR STRING; 9593.ENSGGOP00000046395; -.
DR Ensembl; ENSGGOT00000054355.1; ENSGGOP00000046395.1; ENSGGOG00000016779.3.
DR GeneTree; ENSGT00940000159476; -.
DR InParanoid; A0A2I2ZGK4; -.
DR OMA; GHHCGET; -.
DR Proteomes; UP000001519; Chromosome 3.
DR Bgee; ENSGGOG00000016779; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:1900181; P:negative regulation of protein localization to nucleus; IEA:Ensembl.
DR GO; GO:0034504; P:protein localization to nucleus; IEA:Ensembl.
DR CDD; cd16111; DCX_DCLK3; 1.
DR CDD; cd14185; STKc_DCKL3; 1.
DR Gene3D; 3.10.20.230; Doublecortin domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003533; Doublecortin_dom.
DR InterPro; IPR036572; Doublecortin_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24347; SERINE/THREONINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR24347:SF427; SERINE_THREONINE-PROTEIN KINASE DCLK3; 1.
DR Pfam; PF03607; DCX; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00537; DCX; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF89837; Doublecortin (DC); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50309; DC; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 95..175
FT /note="Doublecortin"
FT /evidence="ECO:0000259|PROSITE:PS50309"
FT DOMAIN 525..782
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 554
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 817 AA; 92523 MW; 5B671AF85034599E CRC64;
MPAATPAPQP PPPPARPAPA CPARPAPGQQ GLCDHSLKYL SSRITERKLQ GSWLPASRGN
LEKPFLGPRG PVVPLFCPRN GLHSAHPENS PLKPRVVTVV KLGGQRPRKI TLLLNRRSVQ
TFEQLLADIS EALSSPRWKN DRVRKLFNLK GREIRSVSDF FREGDAFIAM GKEPLTLKSI
QVAVEELYPN KARALTLAQH SRAPSPRLRS RLFSKALKGD HRCGETETPK SCSEVAGCKA
AMRHQGKIPE ELSLDDRART QKKWGRGKWE PEPSSKPPRE ATLEERHARG EKHLGVEIEK
TSGEIIRCEK CKRERELQQS LERERLSLGT SELDMGKGPM YDMEKLVRTR SCRRSPEANS
ASGEEGWKGD SHRSSPRNPT QELRRPSKSM DKKEDRGPED QESHAQGAAK AKKDLVEVLP
VTEEGLREVK KDTRPMSRSK HGGWLLREHQ AGFEKLRRTR GEEKEAEKEK KPFMSGGRRM
TLRDDQPAKL EKEPKTRPEE NKPERPSGRK PRPMGIIAAN VEKHYETGRV IGDGNFAVVK
ECRHRETRQA YAMKIIDKSR LKGKEDMVDS EILIIQSLSH PNIVKLHEVY ETDMEIYLIL
EYVQGGDLFD AIIESVKFPE PDAALMIMDL CKALVHMHDK SIVHRDLKPE NLLVQRNEDK
STTLKLADFG LAKHVVRPIF TVCGTPTYVA PEILSEKGYG LEVDMWAAGV ILYILLCGFP
PFRSPERDQD ELFNIIQLGH FEFLPPYWDN ISDAAKDLVS RLLVVDPKKR YTAHQVLQHP
WIETAGKTNT VKRQKQVSPS SEGHFRSQHK RVVEQVS
//
