ID A0A2I2ZJ39_GORGO Unreviewed; 447 AA.
AC A0A2I2ZJ39;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Synaptotagmin 7 {ECO:0000313|Ensembl:ENSGGOP00000047286.1};
GN Name=SYT7 {ECO:0000313|Ensembl:ENSGGOP00000047286.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000047286.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000047286.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000047286.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000047286.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the synaptotagmin family.
CC {ECO:0000256|ARBA:ARBA00006996}.
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DR EMBL; CABD030079463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030079464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2ZJ39; -.
DR SMR; A0A2I2ZJ39; -.
DR Ensembl; ENSGGOT00000061176.1; ENSGGOP00000047286.1; ENSGGOG00000016983.3.
DR GeneTree; ENSGT00940000157180; -.
DR Proteomes; UP000001519; Chromosome 11.
DR Bgee; ENSGGOG00000016983; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:InterPro.
DR CDD; cd08386; C2A_Synaptotagmin-7; 1.
DR CDD; cd08405; C2B_Synaptotagmin-7; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037732; C2A_Synaptotagmin-7.
DR InterPro; IPR037741; C2B_Synaptotagmin-7.
DR InterPro; IPR001565; Synaptotagmin.
DR PANTHER; PTHR10024; SYNAPTOTAGMIN; 1.
DR PANTHER; PTHR10024:SF344; SYNAPTOTAGMIN-7; 1.
DR Pfam; PF00168; C2; 2.
DR PRINTS; PR00360; C2DOMAIN.
DR PRINTS; PR00399; SYNAPTOTAGMN.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 179..299
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 310..443
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 119..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 50700 MW; 70A51A39F51AFB7F CRC64;
MYRDPEAASP GAPSRDVLLV SAIITVSLSV TVVLCGLCHW CQRKLGKRYK NSLETVGTPD
SGRGRSEKKA INDLDRDFWN NNESTVQQKW SSYPPKEFIL NISPYAPYGD PRLSLKLPAG
GKAVNTAPVP GQTPHDESDR RTEPRSSVSD LVNSLTSEML MLSPGSEEDE AHEGCSRENL
GRIQFSVGYN FQESTLTVKI MKAQELPAKD FSGTSDPFVK IYLLPDKKHK LETKVKRKNL
NPHWNETFLF EGFPYEKVVQ RILYLQVLDY DRFSRNDPIG EVSIPLNKVD LTQMQTFWKD
LKPCSDGSGS RGELLLSLCY NPSANSIIVN IIKARNLKAM DIGGTSDPYV KVWLMYKDKR
VEKKKTVTMK RNLNPIFNES FAFDIPTEKL RETTIIITVM DKDKLSRNDV IGKIYLSWKS
GPGEVKHWKD MIARPRQPVA QWHQLKA
//
