ID A0A2I2ZJ89_GORGO Unreviewed; 757 AA.
AC A0A2I2ZJ89;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Cullin 3 {ECO:0000313|Ensembl:ENSGGOP00000047305.1};
GN Name=CUL3 {ECO:0000313|Ensembl:ENSGGOP00000047305.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000047305.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000047305.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000047305.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000047305.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; CABD030018856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030018857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030018858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030018859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018877513.1; XM_019021968.1.
DR AlphaFoldDB; A0A2I2ZJ89; -.
DR Ensembl; ENSGGOT00000057354.1; ENSGGOP00000047305.1; ENSGGOG00000007447.3.
DR GeneTree; ENSGT00940000155066; -.
DR OrthoDB; 21270at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001519; Chromosome 2B.
DR Bgee; ENSGGOG00000007447; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF168; CULLIN-3; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 372..624
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 666..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..687
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 87907 MW; 365D12A2BB26830A CRC64;
MFSKRKLRYT EMTMDEKYVN SIWDLLKNAI QEIQRKNNSG LSFEELYRNA YTMVLHKHGE
KLYTGLREVV TEHLINKVRE DVLNSLNNNF LQTLNQAWND HQTAMVMIRD ILMYMDRVYV
QQNNVENVYN LGLIIFRDQV VRYGCIRDHL RQTLLDMIAR ERKGEVVDRG AIRNACQMLM
ILGLEGRSVY EEDFEAPFLE MSAEFFQMES QKFLAENSAS VYIKKVEARI NEEIERVMHC
LDKSTEEPIV KVVERELISK HMKTIVEMEN SGLVHMLKNG KTEDLGCMYK LFSRVPNGLK
TMCECMSSYL REQGKALVSE EGEGKNPVDY IQGLLDLKSR FDRFLLESFN NDRLFKQTIA
GDFEYFLNLN SRSPEYLSLF IDDKLKKGVK GLTEQEVETI LDKAMVLFRF MQEKDVFERY
YKQHLARRLL TNKSVSDDSE KNMISKLKTE CGCQFTSKLE GMFRDMSISN TTMDEFRQHL
QATGVSLGGV DLTVRVLTTG YWPTQSATPK CNIPPAPRHA FEIFRRFYLA KHSGRQLTLQ
HHMGSADLNA TFYGPVKKED GSEVGVGGAQ VTGSNTRKHI LQVSTFQMTI LMLFNNREKY
TFEEIQQETD IPERELVRAL QSLACGKPTQ RVLTKEPKSK EIENGHIFTV NDQFTSKLHR
VKIQTVAAKQ GESDPERKET RQKVDDDRKH EIEAAIVRIM KSRKKMQHNV LVAEVTQQLK
ARFLPSPVVI KKRIEGLIER EYLARTPEDR KVYTYVA
//
