ID A0A2I2ZK55_GORGO Unreviewed; 1408 AA.
AC A0A2I2ZK55;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Rho GTPase activating protein 21 {ECO:0000313|Ensembl:ENSGGOP00000047597.1};
GN Name=ARHGAP21 {ECO:0000313|Ensembl:ENSGGOP00000047597.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000047597.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000047597.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000047597.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000047597.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004284}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004395}.
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DR EMBL; CABD030069616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030069617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030069618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030069619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030069620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030069621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000054932.1; ENSGGOP00000047597.1; ENSGGOG00000006767.3.
DR GeneTree; ENSGT00940000155406; -.
DR Proteomes; UP000001519; Chromosome 10.
DR Bgee; ENSGGOG00000006767; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF16; RHO GTPASE-ACTIVATING PROTEIN 21; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 49..158
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 597..789
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1105..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1310..1408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..850
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..946
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..1015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1086
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1314..1395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1408 AA; 156467 MW; C4743EBF5DD40011 CRC64;
MATRRTGLSE GDGDKLKACE VSKNKDGKEQ SETVSLSEDE TFSWPGPKTV TLKRTSQGFG
FTLRHFIVYP PESAIQFSYK DEENGNRGGK QRNRLEPMDT IFVKQVKEGG PAFEAGLCTG
DRIIKVNGES VIGKTYSQVI ALIQNSDTTL ELSVMPKDED ILQVAYSQDA YLKGNEAYSG
NARNIPEPPP ICYPWLPSAP SAMAQPIEIS PPDSSLSKQQ TSTPVLTQPG RAYRMEIQVP
PSPTDVAKSN TAVCVCNESV RTVIVPSEKV VDLLSNRNNH TGPSHRTEEV RYGVNEQTSL
KTVSRTTSPP LSIPTTHLIH QPAGSRSLEP SGILLKSGNY SGHSDGISSS RSQAVEAPSV
SVNHYSPNSH QHIDWKNYKT YKEYIDNRRL HIGCRTIQER LDSLRAASQS TTDYNQVVPN
RTTLQGRRRS TSHDRVPQSV QIRQRSVSQE RLEDSVLMKY CPRSASQGAL TSPSVSFSNH
RTRSWDYIEG QDETLENVNS GTPIPDSNGE KKQTYKWSGF TEQDDRRGIY ERPRQQEIHK
SFRGSNFTVA PSIANSDNRR MSGRGVGSVS HTWRKGIPSI MRKTFEKKPT ATGTFGVRLD
DCPPAHTNRY IPLIVDICCK LVEERGLEYT GIYRVPGNNA AISSMQEELN KGMADIDIQD
DKWRDLNVIS SLLKSFFRKL PEPLFTNDKY ADFIEANRKE DPLDRLKTLK RLIHDLPEHH
YETLKFLSAH LKTVAENSEK NKMEPRNLAI VFGPTLVRTS EDNMTHMVTH MPDQYKIVET
LIQHHDWFFT EEGAEEPLTT VQEESTVDSQ PVPNIDHLLT NIGRTGVSPG DVSDSATSDS
TKSKGSWGSG KDQYSRELLV SSIFAAASRK RKKPKEKAQP SSSEDELDNV FFKKENVEQC
HNDTKEESKK ESETLGRKQK IIIAKENSTR KDPSTTKDEK ISLGKESTPS EEPSPPRNSK
HNKSPTLSCR FAILKESPRS LLAQKSSHLE ETGSDSGTLL STSSQASLTR FSMKKSTSPE
MKHSEFLANV STITSDYSTT SSATYLTSLD SSRLSPEVQS VAESKGDEAD DERSELISEG
RPVETDSESE FPVFPTALTS ERLFRGKLQE VTKSSRRNSE GSELSCTEGS LTSSLDSRRQ
LFSSHKLIEC DTLSRKKSAR FKSDSGSLGD AKNEKEAPSL TKVFDVMKKG KSTGSLLTPT
RGESEKQEPT WKTKIADRLK LRPRAPADDM FGVGNHKVNA ETAKRKSIRR RHTLGGHRDA
TEISVLNFWK VHEQSGERES ELSAVNRLKP KCSAQDLSIS DWLARERLRT STSDLSRGEI
GDPQTENPST REIATTDTPL SLHCNTGSSS STLASTNRPL LSIPPQSPDQ INGESFQNVS
KNASSAANAQ PHKLSETPGS KAEFHPCL
//
