ID A0A2I2ZL98_GORGO Unreviewed; 347 AA.
AC A0A2I2ZL98;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=SRY-box transcription factor 5 {ECO:0000313|Ensembl:ENSGGOP00000048048.1};
GN Name=SOX5 {ECO:0000313|Ensembl:ENSGGOP00000048048.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000048048.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000048048.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000048048.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000048048.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030085058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030085059; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030085060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030085061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030085062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030085063; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030085064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030085065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030085066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2ZL98; -.
DR SMR; A0A2I2ZL98; -.
DR Ensembl; ENSGGOT00000052094.1; ENSGGOP00000048048.1; ENSGGOG00000016264.3.
DR GeneTree; ENSGT00940000156122; -.
DR OMA; PPPKSKX; -.
DR Proteomes; UP000001519; Chromosome 12.
DR Bgee; ENSGGOG00000016264; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22030; HMG-box_SoxD; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR45789; FI18025P1; 1.
DR PANTHER; PTHR45789:SF3; TRANSCRIPTION FACTOR SOX-5; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 140..208
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 140..208
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 292..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 37..98
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 315..334
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 347 AA; 38850 MW; 16D62B5D8B199A2E CRC64;
MPALRINSGA GPLKASVPAA LASPSARVST IGYLNDHDAV TKAIQEARQM KEQLRREQQV
LDGKVAVVNS LGLNNCRTEK EKTTLESLTQ QLAVKQNEEG KFSHAMMDFN LSGDSDGSAG
VSESRIYRES RGRGSNEPHI KRPMNAFMVW AKDERRKILQ AFPDMHNSNI SKILGSRWKA
MTNLEKQPYY EEQARLSKQH LEKYPDYKYK PRPKRTCLVD GKKLRIGEYK AIMRNRRQEM
RQYFNVGQQA QIPIATAGVV YPGAIAMAGM PSPHLPSEHS SVSSSPEPGM PVIQSTYGVK
GEEPHIKEEI QAEDINGEIY DEYDEEEDDP DVDYGSDSEN HIAGQAN
//
