ID A0A2I2ZLT6_GORGO Unreviewed; 897 AA.
AC A0A2I2ZLT6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Androgen receptor {ECO:0000256|ARBA:ARBA00016946};
DE AltName: Full=Dihydrotestosterone receptor {ECO:0000256|ARBA:ARBA00031402};
DE AltName: Full=Nuclear receptor subfamily 3 group C member 4 {ECO:0000256|ARBA:ARBA00031165};
GN Name=AR {ECO:0000313|Ensembl:ENSGGOP00000048040.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000048040.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000048040.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000048040.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000048040.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030125484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030125485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030125486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030125487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030125488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030125489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2ZLT6; -.
DR Ensembl; ENSGGOT00000060454.1; ENSGGOP00000048040.1; ENSGGOG00000005477.3.
DR GeneTree; ENSGT00940000155516; -.
DR Proteomes; UP000001519; Chromosome X.
DR Bgee; ENSGGOG00000005477; Expressed in liver and 4 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:UniProt.
DR GO; GO:0005496; F:steroid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030521; P:androgen receptor signaling pathway; IEA:InterPro.
DR CDD; cd07173; NR_DBD_AR; 1.
DR CDD; cd07073; NR_LBD_AR; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR001103; Andrgn_rcpt.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR48092:SF31; ANDROGEN RECEPTOR; 1.
DR PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR Pfam; PF02166; Androgen_recep; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00521; ANDROGENR.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 534..609
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 646..877
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 35..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 897 AA; 96665 MW; 3B38EEB310980423 CRC64;
MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP GASLQQQQQQ
QQQHHPRQQQ QQGEDGSPQA HRRGPTGYLV LDEEQQPSQP QSAPECHPER GCVPEPGAAV
AASKGLPQQL PAPPDEDDSA APSTLSLLGP TFPGLSSCSA DLKDILSEAS TMQLLQQQQQ
EAVSEGSSSG RVREASGAPT SSKDNYLGGT SSISDSAKEL CKAVSVSMGL GVEALEHLSP
GEQLRGDCMY APLLGVPPAV RPTPCAPLAE CKGSLLDDSA GKRTEDTAEY SPFKGGYTKG
LEGESLGCSG SAAAGSSGTL ELPSTLSLYK SGALDEAAAY QSRDYYNFPL ALAGPPPPPP
PPHPHARIKL ENPLDYGSAW AAAAAQCRYG DLASLHGAGA AGPGSGSPSA AASSSWHTLF
TAEEGQLYGP CGGGGGGGGG GGGGGGGGGG EAGAVAPYGY TRPPQGLAGQ EGDFTAPDVW
YPGGMVSRVP YPSPTCVKSE MGPWMDSYSG PYGDMRLETA RDHVLPIDYY FPPQKTCLIC
GDEASGCHYG ALTCGSCKVF FKRAAEGKQK YLCASRNDCT IDKFRRKNCP SCRLRKCYEA
GMTLGARKLK KLGNLKLQEE GEASSTTSPT EETTQKLTVS HIEGYECQPI FLNVLEAIEP
GVVCAGHDNN QPDSFAALLS SLNELGERQL VHVVKWAKAL PGFRNLHVDD QMAVIQYSWM
GLMVFAMGWR SFTNVNSRML YFAPDLVFNE YRMHKSRMYS QCVRMRHLSQ EFGWLQITPQ
EFLCMKALLL FSIIPVDGLK NQKFFDELRM NYIKELDRII ACKRKNPTSC SRRFYQLTKL
LDSVQPIARE LHQFTFDLLI KSHMVSVDFP EMMAEIISVQ VPKILSGKVK PIYFHTQ
//
