ID A0A2I2ZQ77_GORGO Unreviewed; 733 AA.
AC A0A2I2ZQ77;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Interferon gamma inducible protein 16 {ECO:0000313|Ensembl:ENSGGOP00000049383.1};
GN Name=IFI16 {ECO:0000313|Ensembl:ENSGGOP00000049383.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000049383.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000049383.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000049383.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000049383.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030006824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018880625.1; XM_019025080.1.
DR AlphaFoldDB; A0A2I2ZQ77; -.
DR Ensembl; ENSGGOT00000062976.1; ENSGGOP00000049383.1; ENSGGOG00000006123.3.
DR GeneID; 101124771; -.
DR CTD; 3428; -.
DR GeneTree; ENSGT00390000013296; -.
DR OrthoDB; 4893941at2759; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000006123; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0002218; P:activation of innate immune response; IEA:InterPro.
DR GO; GO:0035458; P:cellular response to interferon-beta; IEA:InterPro.
DR CDD; cd08305; Pyrin; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 4.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR040205; HIN-200.
DR InterPro; IPR004021; HIN200/IF120x.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR12200:SF5; GAMMA-INTERFERON-INDUCIBLE PROTEIN 16; 1.
DR PANTHER; PTHR12200; INTERFERON-INDUCIBLE PROTEIN AIM2 FAMILY MEMBER; 1.
DR Pfam; PF02760; HIN; 2.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF159141; HIN-2000 domain-like; 4.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50834; HIN_200; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 5..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 193..393
FT /note="HIN-200"
FT /evidence="ECO:0000259|PROSITE:PS50834"
FT DOMAIN 510..709
FT /note="HIN-200"
FT /evidence="ECO:0000259|PROSITE:PS50834"
FT REGION 97..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 733 AA; 82525 MW; BACC0E9DF1EED00F CRC64;
MSVKMEKKYK NIVLLKGLEV INDYHFRMVK SLLSNDLKLN LKMREEYDKI QIADLMEEKF
RGDAGLGKLI QIFKDIPTLE DLAETLKKEK LKVKGLALSR KRKKEVDATS PAPSTSSTVK
TEGAEATPGA QKRKKSTKEK AGPKGSKVSE EQTQPPPPAG AGMSTAMGRS PSPKTSLSAP
PNTSSTENPK TVAKCQVTPR RNVLQKGPVI VKVLSTTKPF EYETPEMEKK IMFHATVATQ
TQFFHVKVLN TSLKEKFNGK KIIIISDYLE YDSLLEVNEE STVSEAGPNQ TFEVPNKIIN
RAKETLKIDI LHKQASGNIV YGVFMLHKKT VNQKTTIYEV QDDRGKMDVV GTGQCHNIPC
EEGDKLQLFC FRLRKKNQMS KLISEMHSFI QIKKKTNPRN SDPKSMKLPQ EQSQLPNPSE
ASTTFPESHL RTPQMPPTTP SSSFFTKKSE DTISKMNDFM RMQILKEESH FPGPFMTSIG
PAERHSHTPQ MPPSTPSSSF LTTLKPRLKT EPEEVSIEDS AQSDLKEVMV LNATESFVYE
PKEQKKMFHA TVATENEVFR VKVFNIDLKE KFTPKKIIAI ANYVCRNGFL EVYPFTLVAD
VNADRNMEIP KGLIRSASVT PKINQLCSQT KGSFVNGVFE VHKKNVRGEF TYYEIQDNTG
KMEVVVHGRL TTINCEEGDK LKLTCFELAP KSGNTGELRS VIHSHIKVIK TRKNKKDILN
PDSSMETSPD FFF
//
