ID A0A2I2ZQE3_GORGO Unreviewed; 492 AA.
AC A0A2I2ZQE3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Kinesin family member 23 {ECO:0000313|Ensembl:ENSGGOP00000049448.1};
GN Name=KIF23 {ECO:0000313|Ensembl:ENSGGOP00000049448.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000049448.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000049448.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000049448.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000049448.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; CABD030096938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030096939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2ZQE3; -.
DR Ensembl; ENSGGOT00000048358.1; ENSGGOP00000049448.1; ENSGGOG00000003971.3.
DR GeneTree; ENSGT00940000155837; -.
DR Proteomes; UP000001519; Chromosome 15.
DR Bgee; ENSGGOG00000003971; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.20.58.1980; -; 1.
DR Gene3D; 2.60.40.4330; Kinesin-like protein Kif23, Arf6-interacting domain; 1.
DR InterPro; IPR032384; Kif23_Arf-bd.
DR InterPro; IPR038105; Kif23_Arf-bd_sf.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24115:SF600; KINESIN-LIKE PROTEIN KIF23; 1.
DR PANTHER; PTHR24115; KINESIN-RELATED; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16540; MKLP1_Arf_bdg; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 1..52
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 274..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 160..229
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 274..296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 56969 MW; 130AEE8B123CD303 CRC64;
MVPYRDSKLT HLFKNYFDGE GKVRMIVCVN PKAEDYEENL QVMRFAEVTQ EVEVARPVDK
AICGLTPGRR YRNQPRGPVG NEPLVTDVVL QSFPPLPSCE ILDINDEQTL PRLIEALEKR
HHLRQMMIDE FNKQSNAFKA LLQEFDNAVL SKENHMQGKL NEKEKMISGQ KLEIERLEKK
NKTLEYKIEI LEKTTTIYEE DKRNLQQELE TQNQKLQRQF SDKRRLEARL QGMVTETTMK
WEKECERRVA AKQLEMQNKL WVKDEKLKQL KAIVTEPKTE KPERPSRERD REKVTQRSVS
PSPVPLSSNY IAQISNGQQL MSQPQLHRRS NSCSSISVAS CISEWEQKIP TYNTPLKVTS
IARRRQQEPG QSKTCIVSDR RRGMYWTEGR EVVPTFRNEI EIEEDHCCRG DIYKTRGGGQ
SVQFTDIETL KQESPNGSRK RRSSTVAPAQ PDGAESEWTD VETRCSVAVE MRAGSQLGPG
YQHHAQPKRK KP
//
