ID A0A2I2ZQL2_GORGO Unreviewed; 1079 AA.
AC A0A2I2ZQL2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Solute carrier family 12 member 4 {ECO:0000313|Ensembl:ENSGGOP00000049513.1};
GN Name=SLC12A4 {ECO:0000313|Ensembl:ENSGGOP00000049513.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000049513.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000049513.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000049513.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000049513.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; CABD030101690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018867554.1; XM_019012009.1.
DR AlphaFoldDB; A0A2I2ZQL2; -.
DR Ensembl; ENSGGOT00000048998.1; ENSGGOP00000049513.1; ENSGGOG00000004986.3.
DR GeneID; 101135281; -.
DR CTD; 6560; -.
DR GeneTree; ENSGT00940000157672; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000001519; Chromosome 16.
DR Bgee; ENSGGOG00000004986; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000622; KCC1.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF46; SOLUTE CARRIER FAMILY 12 MEMBER 4; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
DR PRINTS; PR01082; KCLTRNSPORT1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 113..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 607..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 118..294
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 412..689
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 703..819
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 834..1079
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1079 AA; 119629 MW; 94539D59121C2019 CRC64;
MAAEGALCGF VYLEGTAWAV PEDTEPLASC TLGHGNHRES SPFLSPLEAS RGSDYYDRNL
ALFEEELDIR PKVSSLLGKL VSYTNLTQGA KEHEEAESGE GIRRRAAEAP SMGTLMGVYL
PCLQNIFGVI LFLRLTWMVG TAGVLQALLI VLICCCCTLL TAISMSAIAT NGVVPAGGSY
FMISRSLGPE FGGAVGLCFY LGTTFAAAMY ILGAIEILLT YIAPPAAIFY PSGAHDTSNA
TLNNMRVYGT IFLTFMTLVV FVGVKYVNKF ASLFLACVII SILSIYAGGI KSIFDPPVFP
VCMLGNRTLS RDQFDICAKT AVVDNETVAT QLWSFFCHSP NLTTDSCDPY FMLNNVTEIP
GIPGAAAGVL QENLWSAYLE KGDIVEKHGL PSADAPSLKE SLPLYVVADI ATSFTVLVGI
FFPSVTGIMA GSNRSGDLRD AQKSIPVGTI LAIITTSLVY FSSVVLFGAC IEGVVLRDKY
GDGVSRNLVV GTLAWPSPWV IVIGSFFSTC GAGLQSLTGA PRLLQAIAKD NIIPFLRVFG
HGKVNGEPTW ALLLTALIAE LGILIASLDM VAPILSMFFL MCYLFVNLAC AVQTLLRTPN
WRPRFKYYHW ALSFLGMSLC LALMFVSSWY YALVAMLIAG MIYKYIEYQG AEKEWGDGIR
GLSLSAARYA LLRLEEGPPH TKNWRPQLLV LLKLDEDLHV KYPRLLTFAS QLKAGKGLTI
VGSVIQGSFL ESYGEAQAAE QTIKNMMEIE KVKGFCQVVV ASKVREGLAH LIQSCGLGGM
RHNSVVLGWP YGWRQSEDPR AWKTFIDTVR CTTAAHLALL VPKNIAFYPS NHERYLEGHI
DVWWIVHDGG MLMLLPFLLR QHKVWRKCRM RIFTVAQMDD NSIQMKKDLA VFLYHLRLEA
EVEVVEMHNS DISAYTYERT LMMEQRSQML RQMRLTKTER EREAQLVKDR HSALRLESLY
SDEEDESAVG ADKIQMTWTR DKYMTETWDP SHAPDNFREL VHIKPDQSNV RRMHTAVKLN
EVIVTRSHDA RLVLLNMPGP PRNSEGDENY MEFLEVLTEG LERVLLVRGG GREVITIYS
//
