ID A0A2I2ZR09_GORGO Unreviewed; 501 AA.
AC A0A2I2ZR09;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Calcium-binding and coiled-coil domain-containing protein 2 {ECO:0000256|ARBA:ARBA00040931};
DE AltName: Full=Nuclear domain 10 protein NDP52 {ECO:0000256|ARBA:ARBA00041519};
GN Name=CALCOCO2 {ECO:0000313|Ensembl:ENSGGOP00000049592.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000049592.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000049592.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000049592.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000049592.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Cytoplasmic vesicle, autophagosome
CC membrane {ECO:0000256|ARBA:ARBA00037854}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00037854}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the CALCOCO family.
CC {ECO:0000256|ARBA:ARBA00037963}.
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DR EMBL; CABD030037334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030037335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030037336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030037337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018883494.1; XM_019027949.1.
DR RefSeq; XP_018883495.1; XM_019027950.1.
DR RefSeq; XP_018883496.1; XM_019027951.1.
DR AlphaFoldDB; A0A2I2ZR09; -.
DR STRING; 9593.ENSGGOP00000049592; -.
DR Ensembl; ENSGGOT00000049677.1; ENSGGOP00000049592.1; ENSGGOG00000005537.3.
DR GeneTree; ENSGT00950000183025; -.
DR InParanoid; A0A2I2ZR09; -.
DR OMA; PFCFRNP; -.
DR Proteomes; UP000001519; Chromosome 5.
DR Bgee; ENSGGOG00000005537; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005776; C:autophagosome; IBA:GO_Central.
DR GO; GO:0000421; C:autophagosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016605; C:PML body; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:1901098; P:positive regulation of autophagosome maturation; IBA:GO_Central.
DR GO; GO:0034341; P:response to type II interferon; IEA:Ensembl.
DR GO; GO:0098792; P:xenophagy; IBA:GO_Central.
DR CDD; cd21968; Zn-C2H2_CALCOCO2; 1.
DR Gene3D; 2.60.40.2840; -; 1.
DR Gene3D; 6.20.250.40; -; 1.
DR InterPro; IPR041641; CALCOCO1/2_Zn_UBZ1.
DR InterPro; IPR041611; SKICH.
DR PANTHER; PTHR31915:SF4; CALCIUM-BINDING AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR31915; SKICH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF17751; SKICH; 1.
DR PROSITE; PS51905; ZF_UBZ1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01253}.
FT DOMAIN 474..499
FT /note="UBZ1-type"
FT /evidence="ECO:0000259|PROSITE:PS51905"
FT COILED 142..333
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 369..403
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 501 AA; 58431 MW; 50693C83F78DD646 CRC64;
MEETIKDPPT SAVLLDHCHF SQVIFNSVEK FYTPGGDVTC HYTFTQHFIP RRKDWIGIFR
VGWKTTREYY TFMWVTLPID LNNKSAKQQE VQFKAYYLPK DDEYYQFCYV DEDGVVRGAS
IPFQFRPENE EDILVVTTQG EVEEIEQHNK ELCKENQELK DSCVSLQKQN SDMQAELQKK
QEELETLQSI NKKLELKVKE QKDYWETELL QLKEQNQKMS SENEKMGIRV DQLQAQLSTQ
EKEMEKLVQG DQDKTEQLEQ LKKENDHLFL SLTEQRKDQK KLEQTVEQMK QNETTAMKKQ
QELMEPRNKK AALTVEEQLA QEVERLKAKV EARKAYFLEK YKECQRLHKQ ISQLGAAALD
ENFDLSKRLS ENKIICNALQ REKERLEGEN DLLKRENSRL LSYMGLDFNS LPYQVPTSDE
GGAGQNPGLA YGNPYSGIQE SSSPSPLSIK KCPICKADDI CDHTLEQQQM QPLCLNCPIC
DKIFPATEKQ IFEDHVFCHS L
//
