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Database: UniProt
Entry: A0A2I2ZR80_GORGO
LinkDB: A0A2I2ZR80_GORGO
Original site: A0A2I2ZR80_GORGO 
ID   A0A2I2ZR80_GORGO        Unreviewed;      1271 AA.
AC   A0A2I2ZR80;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=SOS Ras/Rho guanine nucleotide exchange factor 2 {ECO:0000313|Ensembl:ENSGGOP00000049525.1};
GN   Name=SOS2 {ECO:0000313|Ensembl:ENSGGOP00000049525.1};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000049525.1, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000049525.1, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000049525.1, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA   Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA   Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA   Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA   Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA   Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA   Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA   Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA   Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA   Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA   Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000049525.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   EMBL; CABD030092259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030092260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030092261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2I2ZR80; -.
DR   Ensembl; ENSGGOT00000057937.1; ENSGGOP00000049525.1; ENSGGOG00000015477.3.
DR   GeneTree; ENSGT00940000158324; -.
DR   Proteomes; UP000001519; Chromosome 14.
DR   Bgee; ENSGGOG00000015477; Expressed in testis and 6 other cell types or tissues.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd01261; PH_SOS; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 6.10.250.3060; -; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF150; SON OF SEVENLESS HOMOLOG 2; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF47113; Histone-fold; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT   DOMAIN          170..265
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          380..483
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          534..678
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          717..956
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          957..1000
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1015..1035
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1081..1271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        973..993
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1090..1104
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1112..1128
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1136..1164
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1225..1240
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1271 AA;  145751 MW;  751D6969855A9DAF CRC64;
     KVQEQVHPTL SANEESLYYI EELIFQLLNK LCMAQPRTVQ DVEERVQKTF PHPIDKWAIA
     DAQSAIEKRK RRNPLLLPVD KIHPSLKEVL GYKVDYHVSL YIVAVLEYIS ADILKLAGNY
     VFNIRHYEIS QQDIKVSMCA DKVLMDMFDQ DDIGLVSLCE DEPSSSGELN YYDLVRTEIA
     EERQYLRELN MIIKVFREAF LSDRKLFKPS DIEKIFSNIS DIHELTVKLL GLIEDTVEMT
     DESSPHPLAG SCFEDLAEEQ AFDPYETLSQ DILSPEFHEH FNKLMARPAV ALHFQQLKAC
     SEEQEDRECL NQAITALMNL QGSMDRIYKQ YSPRRRPGDP VCPFYSHQLR SKHLAIKKMN
     EIQKNIDGWE GKDIGQCCNE FIMEGPLTRI GAKHERHIFL FDGLMISCKP NHGQTRLPGY
     SSAEYRLKEK FVMRKIQICD KEDTCEYKHA FELVSKDENS IIFAAKSAEE KNNWMAALIS
     LHYRSTLDRM LDSVLLKEEN EQPLRLPSPE VYRFVVKDSE ENIVFEDNLQ SRSGIPIIKG
     GTVVKLIERL TYHMYADPNF VRTFLTTYRS FCKPQELLSL LIERFEIPEP EPTDADKLAI
     EKGEQPISAD LKRFRKEYVQ PVQLRILNVF RHWVEHHFYD FERDLELLER LESFISSVRG
     KAMKKWVESI AKIIRRKKQA QANGISHNIT FESPPPPIEW HISKPGQFET FDLMTLHPIE
     IARQLTLLES DLYRKVQPSE LVGSVWTKED KEINSPNLLK MIRHTTNLTL WFEKCIVEAE
     NFEERVAVLS RIIEILQVFQ DLNNFNGVLE IVSAVNSVSV YRLDHTFEAL QERKRKILDE
     AVELSQDHFK KYLVKLKSIN PPCVPFFGIY LTNILKTEEG NNDFLKKKGK DLINFSKRRK
     VAEITGEIQQ YQNQPYCLRI EPDMRRFFEN LNPMGSASEK EFTDYLFNKS LEIEPRNCKQ
     PPRFPRKSTF SLKSPGIRPN TGRHGSTSGT LRGHPTPLER EPCKISFSRI AETELESTVS
     APTSPNTPST PPVSASSDLS VFLDVDLNSS CGSNSIFAPV LLPHSKSFFS SCGSLHKLSE
     EPLIPPPLPP RKKFDHDASN SKGNMKSDDD PPAIPPRQPP PPKVKPRVPV PTGAFDGPLH
     SPPPPPPRDP LPDTPPPVPL RPPEHFINCP FNLQPPPLGH LHRDSDWLRD ISTCPNSPST
     PPSTPSPRVP RRCYVLSSSQ NNLAHPPAPP VPPRQNSSPH LPKLPPKTYK RELSHPPLYR
     LPLLENAETP Q
//
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