ID A0A2I2ZR80_GORGO Unreviewed; 1271 AA.
AC A0A2I2ZR80;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=SOS Ras/Rho guanine nucleotide exchange factor 2 {ECO:0000313|Ensembl:ENSGGOP00000049525.1};
GN Name=SOS2 {ECO:0000313|Ensembl:ENSGGOP00000049525.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000049525.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000049525.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000049525.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000049525.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030092259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030092260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030092261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2ZR80; -.
DR Ensembl; ENSGGOT00000057937.1; ENSGGOP00000049525.1; ENSGGOG00000015477.3.
DR GeneTree; ENSGT00940000158324; -.
DR Proteomes; UP000001519; Chromosome 14.
DR Bgee; ENSGGOG00000015477; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF150; SON OF SEVENLESS HOMOLOG 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 170..265
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 380..483
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 534..678
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 717..956
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 957..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1015..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1081..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1128
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1164
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1225..1240
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1271 AA; 145751 MW; 751D6969855A9DAF CRC64;
KVQEQVHPTL SANEESLYYI EELIFQLLNK LCMAQPRTVQ DVEERVQKTF PHPIDKWAIA
DAQSAIEKRK RRNPLLLPVD KIHPSLKEVL GYKVDYHVSL YIVAVLEYIS ADILKLAGNY
VFNIRHYEIS QQDIKVSMCA DKVLMDMFDQ DDIGLVSLCE DEPSSSGELN YYDLVRTEIA
EERQYLRELN MIIKVFREAF LSDRKLFKPS DIEKIFSNIS DIHELTVKLL GLIEDTVEMT
DESSPHPLAG SCFEDLAEEQ AFDPYETLSQ DILSPEFHEH FNKLMARPAV ALHFQQLKAC
SEEQEDRECL NQAITALMNL QGSMDRIYKQ YSPRRRPGDP VCPFYSHQLR SKHLAIKKMN
EIQKNIDGWE GKDIGQCCNE FIMEGPLTRI GAKHERHIFL FDGLMISCKP NHGQTRLPGY
SSAEYRLKEK FVMRKIQICD KEDTCEYKHA FELVSKDENS IIFAAKSAEE KNNWMAALIS
LHYRSTLDRM LDSVLLKEEN EQPLRLPSPE VYRFVVKDSE ENIVFEDNLQ SRSGIPIIKG
GTVVKLIERL TYHMYADPNF VRTFLTTYRS FCKPQELLSL LIERFEIPEP EPTDADKLAI
EKGEQPISAD LKRFRKEYVQ PVQLRILNVF RHWVEHHFYD FERDLELLER LESFISSVRG
KAMKKWVESI AKIIRRKKQA QANGISHNIT FESPPPPIEW HISKPGQFET FDLMTLHPIE
IARQLTLLES DLYRKVQPSE LVGSVWTKED KEINSPNLLK MIRHTTNLTL WFEKCIVEAE
NFEERVAVLS RIIEILQVFQ DLNNFNGVLE IVSAVNSVSV YRLDHTFEAL QERKRKILDE
AVELSQDHFK KYLVKLKSIN PPCVPFFGIY LTNILKTEEG NNDFLKKKGK DLINFSKRRK
VAEITGEIQQ YQNQPYCLRI EPDMRRFFEN LNPMGSASEK EFTDYLFNKS LEIEPRNCKQ
PPRFPRKSTF SLKSPGIRPN TGRHGSTSGT LRGHPTPLER EPCKISFSRI AETELESTVS
APTSPNTPST PPVSASSDLS VFLDVDLNSS CGSNSIFAPV LLPHSKSFFS SCGSLHKLSE
EPLIPPPLPP RKKFDHDASN SKGNMKSDDD PPAIPPRQPP PPKVKPRVPV PTGAFDGPLH
SPPPPPPRDP LPDTPPPVPL RPPEHFINCP FNLQPPPLGH LHRDSDWLRD ISTCPNSPST
PPSTPSPRVP RRCYVLSSSQ NNLAHPPAPP VPPRQNSSPH LPKLPPKTYK RELSHPPLYR
LPLLENAETP Q
//