ID A0A2I2ZSN2_GORGO Unreviewed; 483 AA.
AC A0A2I2ZSN2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Solute carrier family 19 member 1 {ECO:0000313|Ensembl:ENSGGOP00000050041.1};
GN Name=SLC19A1 {ECO:0000313|Ensembl:ENSGGOP00000050041.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000050041.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000050041.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000050041.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000050041.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC 2.A.48) family. {ECO:0000256|ARBA:ARBA00005773}.
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DR EMBL; CABD030119607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030119608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030119609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030119610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030119611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2ZSN2; -.
DR Ensembl; ENSGGOT00000068237.1; ENSGGOP00000050041.1; ENSGGOG00000011734.3.
DR GeneTree; ENSGT00950000183022; -.
DR Proteomes; UP000001519; Chromosome 21.
DR Bgee; ENSGGOG00000011734; Expressed in adult mammalian kidney and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR002666; Folate_carrier.
DR InterPro; IPR036259; MFS_trans_sf.
DR NCBIfam; TIGR00806; rfc; 1.
DR PANTHER; PTHR10686; FOLATE TRANSPORTER; 1.
DR PANTHER; PTHR10686:SF12; REDUCED FOLATE TRANSPORTER; 1.
DR Pfam; PF01770; Folate_carrier; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 382..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 483 AA; 52598 MW; F8B5898888E25075 CRC64;
MRPQPAELAP GGRGNEACSI HSEVTNEITP VLSYSYLAVL VPVFLLTDYL RYTPVLLLQG
LSFVSVWLLL LLGHSVAHMQ LMELFYSVTM AARIAYSSYI FSLVRPARYQ RVAGYSRAAV
LLGVFTSSVL GQLLVTVGRV SFSTLNYISL AFLTFSVVLA LFLKRPKRSL FFNRDDRGRC
ETSASELERM NPGPGGKLGH ALRVACGDSV LARMLRELGD SLRRPQLRLW SLWWVFNSAG
YYLVVYYVHI LWNEVDPTTN SARVYNGAAD AASTLLFQIA SSLSKELCAL VFGVNTFFAT
IVKTIITFIV SDVRGLGLPV RKQFQLYSVY FLILSIIYFL GAMLDGLRHC QRGHHPRQPP
AQGLRSAAEE KAAQALSMQD KGLGGLQPAQ SPPLSPEDSL GAVGPASLEQ RQSNPYLAPA
PAPQAAEFLS PVTTPSPCTL CSAQASGPEA ADETCPQLAV HPPGVSKLGL QCLPSDGVQN
VNQ
//
