ID A0A2I2ZTI3_GORGO Unreviewed; 1385 AA.
AC A0A2I2ZTI3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=LIM domain 7 {ECO:0000313|Ensembl:ENSGGOP00000050452.1};
GN Name=LMO7 {ECO:0000313|Ensembl:ENSGGOP00000050452.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000050452.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000050452.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000050452.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000050452.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030089849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030089850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030089851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030089852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030089853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030089854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030089855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000046608.1; ENSGGOP00000050452.1; ENSGGOG00000012590.3.
DR GeneTree; ENSGT00950000183159; -.
DR Proteomes; UP000001519; Chromosome 13.
DR Bgee; ENSGGOG00000012590; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR GO; GO:0023051; P:regulation of signaling; IEA:InterPro.
DR CDD; cd00136; PDZ; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR031865; DUF4757.
DR InterPro; IPR029978; LMO-7.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR46767; LIM DOMAIN ONLY PROTEIN 7; 1.
DR PANTHER; PTHR46767:SF1; LIM DOMAIN ONLY PROTEIN 7; 1.
DR Pfam; PF15949; DUF4757; 2.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 757..833
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 25..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 970..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1067..1343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..58
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..504
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..991
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 993..1020
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1021..1055
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1067..1107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1198
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1229..1343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1385 AA; 158208 MW; 61B61CD819E47811 CRC64;
MQDYNKDDMS YRRISAVEPK TALPFNRFLP NKSRQPSYVP APLRKKKPDK HEDNRRSWAS
PVYTEADGTF SSNQRRIWGT NVENWPTVQG TSKSSCYLEE EKAKTRSIPN IVKDDLYVRK
LSPVMPNPGN AFDQFLPKCW TPEDVNWKRI KRETYKPWYK EFQGFSQFLL LQALQTYSDD
ILSSETHTKI DPTSGPRLIT RRKNLSYAPG YRRDDLEMAA LDPDLENDDF FVRKTGAFHA
NPYVLRAFED FRKFSEQDDS VERDIILQCR EGELVLPDLE KDDMIVRRIP AQKKEVPLSG
APDRYHPVPF PEPWTLPPEI QAKFLCVLER TCPSKEKSNS CRILVPSYRQ KKDDMLTRKI
QSWKLGTTVP PISFTPGPCS EADLKRWEAI REASRLRHKK RLMVERLFQK IYGENGSKSM
SDVSAEDVQN LRQLRYEEMQ KIKSQLKEQD QKWQDDLAKW KDRRKSYTSD LQKKKEEREE
IEKQAHEKSE RSSKTFKEML QDRESQNQKS TVPSRRRMYS FDDVLEEGKR PPTMTVSEAS
YQSERVEEKG ATYPSEIPKE DSTTFAKRED RVTTEIQLPS QSPVEEQSPA SLSSLRSRST
QMESTRVSAS LPRSYQKTDT VRLTSVVTPR PFGSQTRGIS SLPRSYTMDD AWKYNGDVED
VKRTPNNVVS TPAPSPDASQ LASSLSSQKE VAATEEDVTR LPSPTSPFSS LSQDQAATSK
ATLSSTSGLD LMSESGEGEI SPQREVSRSQ DQFSDMRISI NQTPGKSLDF GFTIKWDIPG
IFIASVEAGS PAEFSQLQVD DEIIAINNTK FSYNDSKEWE EAMAKAQETG HLVMDVRRYG
KAGSPETKWI DATSGIYNSE KSSNLSVTTD FSESLQSSNI ESKEINGIHD ESNAFESKAS
ESISLKNLKR RSQFFEQGSS DSVVPDLPVP TISAPSRWVW DQEEERKRQE RWQKEQDRLL
QEKYQREQEK LRKEWQRAKQ EAERENSKYL DEELMVLSSN SMSLTTREPS LATWEATWSE
GSKSSDREGT RAGEEERRQP QEEVVHEDQG KKLQDQLVIE RERKWEQQLQ EQQEQKRLQA
EAEEQKHPAE EQKRQAELER ETSVRIYQYR RPVDSYDIPK TEEASSGFLP GDRNKSRSAT
ELDDYSTNKN GNNKYLDRIG NTTSSQRRSK KEQVPSGAEL ERQQILQEMR KRTPLHNDNS
WIRQRSASVN KEPVSLPGIM RRGESLDNLD SPRSNSWRQP PWLNQPTGFY ASSSVQDFSR
PPPQLVSTSN RAYMRNPSSS VPPPSAGSVK TSTTGVATTQ SPTPRSHSPS ASQSGSQLRN
SVLPVSVTSE PLPQELKSGS ETTNCTATTA ISDSNLDGQP PCDVSLHTKA LLQIEEEVVA
ARVDL
//
