ID A0A2I2ZTP4_GORGO Unreviewed; 726 AA.
AC A0A2I2ZTP4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Zinc finger protein X-linked {ECO:0000313|Ensembl:ENSGGOP00000050421.1};
GN Name=ZFX {ECO:0000313|Ensembl:ENSGGOP00000050421.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000050421.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000050421.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000050421.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000050421.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CABD030123395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030123396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030123397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030123398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2ZTP4; -.
DR Ensembl; ENSGGOT00000042445.1; ENSGGOP00000050421.1; ENSGGOG00000004053.3.
DR GeneTree; ENSGT00940000158684; -.
DR Proteomes; UP000001519; Chromosome X.
DR Bgee; ENSGGOG00000004053; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 9.
DR InterPro; IPR006794; Transcrp_activ_Zfx/Zfy-dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR47772:SF5; ZGC:162958 PROTEIN-RELATED; 1.
DR PANTHER; PTHR47772; ZINC FINGER PROTEIN 200; 1.
DR Pfam; PF00096; zf-C2H2; 7.
DR Pfam; PF13909; zf-H2C2_5; 1.
DR Pfam; PF04704; Zfx_Zfy_act; 2.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 346..376
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 377..399
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 409..436
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 440..468
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 469..496
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 497..525
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 526..553
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 554..582
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 583..610
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 611..639
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 640..667
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 668..696
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 697..724
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 726 AA; 82089 MW; 96FA704AAB1BB10D CRC64;
MDGDQIVVEV QETVFVSDVV DSDITVHNFV PDDPDSVVIQ DVIEDVVIED VQCPDIMEEA
DVSETVIIPE QVLDSDVTEE VSLAHCTVPD DVLASDITSA SMSMPEHVLT GDSIHVSDVG
HVGHVEHVVH DSVVEAEIVT DPLTTDVVSE EVLVADCASE AVIDANGIPV DQQDDDKGNC
EDYLMISLDD AGKIEHDGSS GMTMDTESEI DACKVDGTCP EVIKVYIFKA DPGEDDLGGT
VDIVESEPEN DHGVELLDQN SSIRVPREKM VYMTVNDSQP EDEDLSNNSD GIENRNGTAS
ALLHIDESAG LGRLAKQKPK KRRRPDSRQY QTAIIIGPDG HPLTVYPCMI CGKKFKSRGF
LKRHMKNHPE HLAKKKYRCT DCDYTTNKKI SLHNHLESHK LTSKAEKAIE CDECGKHFSH
AGALFTHKMV HKEKGANKMH KCKFCEYETA EQGLLNRHLL AVHSKNFPHI CVECGKGFRH
PSELKKHMRI HTGEKPYQCQ YCEYRSADSS NLKTHVKTKH SKEMPFKCDI CLLTFSDTKE
VQQHALIHQE SKTHQCLHCD HKSSNSSDLK RHIISVHTKD YPHKCDMCDK GFHRPSELKK
HVAAHKGKKM HQCRHCDFKI ADPFVLSRHI LSVHTKDLPF RCKRCRKGFR QQSELKKHMK
THSGRKVYQC EYCEYSTTDA SGFKRHVISI HTKDYPHRCE YCKKGFRRPS EKNQHIMRHH
KEVGLP
//
