ID A0A2I2ZUI0_GORGO Unreviewed; 4375 AA.
AC A0A2I2ZUI0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=HECT domain E3 ubiquitin protein ligase 4 {ECO:0000313|Ensembl:ENSGGOP00000050706.1};
GN Name=HECTD4 {ECO:0000313|Ensembl:ENSGGOP00000050706.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000050706.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000050706.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000050706.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000050706.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030086755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030086756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030086757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030086758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9593.ENSGGOP00000050706; -.
DR Ensembl; ENSGGOT00000044021.1; ENSGGOP00000050706.1; ENSGGOG00000001169.3.
DR GeneTree; ENSGT00910000144226; -.
DR InParanoid; A0A2I2ZUI0; -.
DR OMA; TRACMVL; -.
DR Proteomes; UP000001519; Chromosome 12.
DR Bgee; ENSGGOG00000001169; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0042593; P:glucose homeostasis; IBA:GO_Central.
DR CDD; cd13735; SPRY_HECT_like; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR043366; HECTD4.
DR InterPro; IPR035781; SPRY_HECTD4.
DR PANTHER; PTHR46435; E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED; 1.
DR PANTHER; PTHR46435:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 4016..4375
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1878..1909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2000..2021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2603..2629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3243..3303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3401..3437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3711..3787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1878..1893
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1894..1909
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2000..2014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3243..3271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3401..3418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3711..3728
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3757..3787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 4343
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 4375 AA; 480364 MW; 00CC31229A2FB858 CRC64;
LGSSSPASAS QVAGSIGVCH PPSLPFLCNF FFLDILTFET KNPSELAERL RSVCGNQSNA
YARLLEYRLN ALRGLWNAQR QLALEEQHER ESSGDEETLA LLKRQGLLQQ PEQAPFTSRM
GLLLVFPLIQ SQSRTDPSLC NITAEVLLNC LRDCQPLSLT KEPADCLNGI ETLLCSWLEE
TSDTGRHIPH KQKENAAAAL VALACARGSL KTFVHTVHLL QKQTDLGSLP VADVLYRLLL
LEGGPGSPSC LLGGKHIVSW GYEDMLPAPD SNTGSSSENK DADLGRCLTA DGLYLYTTNS
VGRGVSKLGS GLHGTLRGFV YCRNEELEPG WVAFGSGSLL HRPVSFDNKP HSLFQVIDQN
TLQVCQVVPM PANHLPIGST MSTVHLSSDG TYFYWIWSPA SLNEKTPKGH SVFMDIFELV
VENGVFVANP LQERTILMRK EGESAKSINE MLLSRLSRYR ASPSATLAAL TGSTISNTLK
EDQAANTSCG LPLKMLRKTP IYTCGTYLVM LVPPPGGSGS SATRSLFGGT SGLSSLKILA
SSLVYNISDG QFTSRADLID AAGSSLGRGA LVPGLGACYD TVNNMLWTCS NDYIDQWCNP
GNQAFHYVCQ RLGVSHIITE PKEEAITTNE VINQLLHHVG AMCIHQLNLL ATNPNLPITS
VLGKQHPIEA HHLSSICDIM EKAMVNGDTC IIRCILVVFQ VVFKFFFSPQ TERNRDIIRR
SGLLLWQLLM APKDQIGPEI QKEVCLAISS GLNILYPGET EINNLLKLVL TEGERNSGLS
QLRDVILTNL AEQLQNNRFG SDEDDHYRLN DELLHYILKI VVRESCILIT KCQTVSKDDF
QKLLSTVPVS KNVFNENCVS KNKIIIIIKT PENSNNEKEL KVSILALATQ ILTGCDEVLE
MLQQVTTALI NSDIADREQR LKGLEQVTKA TMLGHLLPVL LTSLMHPNLQ TLIMADALMP
QLVQLVLYTS QTALLLKTQC PVFAEVGCSP CGAPDQKCRL FPDERMLEEK EEPGFLTGLK
IPAPWAAGKT VETVHPVRDN YKFKETVHIP GARCLYLRFD SRCSSQYDYD KLVIYAGPNT
NSRKVAEYGG NTLGYGSRSV LGTGWPKDLV KVEGDTVTFS FEMRSGREHN TPDKAMWGFA
CTVRAQESSE DVSGGLPFLV DLALGLSVLA CSMLRILYNG PEITKEEEAC QELLRSKLLQ
RCQWQVEANG VISPALTPSP SPLPLTIEED REFTYPSDVL VPPVGNYFDL PRIRLPPGIM
IKLREISGRA RPQFRPSIKE VIQPDVMEEM VVSCVIKHLN LVDALQSLIN FQYQEEHAEE
YDLLCKIMGE TFKKLNAMER QLQSVAELEQ KWQSEVDDAM QGKLENNMPF FYDYHFNENK
MKELELLCSM KEVSFDGNDL ENMVLSLREK FLQEVNSLIQ KPSHPLAKTK TLVKSLMNRA
ELLLHVTIAA QSGLTRSISG TPAETPACKS ASETKVISHA VRQPVFLRSM SAPSDLEMIG
NEDLEFTRAN QRRRHVTSHR SSSFTLLQSL AIEDSRDKPT YSVLLGQLFA FIGTNPDQAV
SSSSFLLAAQ TRWRRGNTRK QALVHMRELL TAAVRVGGVT HLVGPVTMVL QGGPRIEELT
CGGMVEQVQE AFGETMTSVV SLCARYPIAC ANSIGLLCTI PYTRSEEKCL VRSGLVQLMD
RLCSLSSQTE SSSSEKQTKK QKVATMAWAA FQVLANRCVE WEKEEGGSTE AVHSGLARQV
SSLLTNHLAR ATECCGNQAA GNDALQDVLS LLNDLSRSHI GKAILSQPAC VSKLLSLLLD
QRPSPKLVLI ILQLCRAALP LMSVEDCGNV ELPPWSYSVP SLNSEQEDPS DPASKIASLL
LAKLADYVVP GCQTVLSPTA SEPDTTLTKT SPKNSLKGDK DPGEESEAVD GKLSIFIHKR
EDQSSHEVLQ PLLSSSEGRP FRLGTGANME KVVKMDRDMT KGGCCEVITE EAAAALRKAT
KWAQSGLIVS IGPPVESINP ETVSGLSTGD KKKTAQTSIC RERNSELART DPVRPFISGH
VANSMAAEVI ALLHSLLMAP ESNAAQIWTT TAEKVLSRAL MYIPQLGKYA ESILENGSSS
GRKLAKLQRI ARQAVAALCA LGGFKETIKI GSEVQVLGRG ISGSIGVVAS INEQEGIATV
RFPPIDCRKT SQASDTLTIP LSRLCVPRSE ALPLHKLSIT EKVVQAVQSM LLPQEGSLSI
HTSLPATGDG SAPVMAVVRL LAEIRTRACL VMAQLLEDSL FCEEFIQQCP AAVEVLNLVA
QECSAGERLA VVEVQCERLR MLYRDCARPP PPPLQADRRQ PKEITWSPSR VFPPVRACMF
SSHLTSVTFL ADPSAGGGLP RGTFIYATSP LPVQAPSFYW EIEIVSYGDT DDDTGPIVSF
GFTTEAEKRD GAWTNPVGTC LFHNNGRAVH YNGSSLLQWK SVRLDVTLSP GDVAGIGWER
TEGTPPPPGQ PAKGRVYFTY CGQRLSPYLE DVSGGMWPVV HIQKKNTKTR ANFGSRPFAY
AEGQAHRNAA DLCTDLAEEI SANFEALPFA MASDSDNDAG TSIASDPGTH GPPCRIAAVA
TAQQQYDSDT SCHYKVELSY ENFITSGPDP HPPPIADDES DDDDDDDIPQ EDHYALLVKA
WETKVFPTIR RRFRNEAERK SGLDQIKGAL QLGMVDIARQ TVEFLYEENG GIPRDLYLPT
IEDIKDEANK FTIDKVRKGL TVVTRSPDSN NVASSAVGTA LPKFAIRGML KTFGLHGVVL
DVDSVNELVQ VETYLRSEGV LVRYWYPIDM LERPPAGYRR TATNGLVTLD NTNLQIHREL
LRCEAALARL YCRMALLNIF APKLPHLFTR LFHIPAIRDI TLEHLQLLSN QLLAPPLPDG
TISSSSILLA QSLQHCIHSQ NCSATDLFYQ GNSQTVREWL NVAITRTLHQ GEESLLELTK
QICSFLQTAP EQFPSEEFPI SESKVNMDVN FPGAAFVVVS CKESQSGFRK DSSLYKAPWA
RVLVYGLGHK VKRNGQLNLI EAACYPRDAS PANTGLAPPP TADQYPSVVL STDRVHIKLG
VSPPPGAVLV LHSLPLEFPL AMAFAEQLLS WKSEDSEGKS EDEPDTIPTS VLLQVVELLG
NFLWTTDMAA CVKELVFHLL AELLRTVHTL EQRRHPAGLS SSIALQLNPC LAMLMALQSE
LHKLYDEETQ NWVSGGACGG SGGAAAGDQG RFSTYFHALM EGCLAVAEVT LPTNMSVTAS
GVTSATAPNL SDSSSSSSSS PGQTPQSPSL LSKRKKVKMK REKASSSGKR QSSRTVDSDP
TVLSIGGSKP EDMLWFHRAL TLLIILRHLT RKDPQGLGVT SDAIADACQA LVGPTAHSRL
LVISGIPTHL DEGVVRGAIR KACNAHGGVF KDEIYIPLQE EDTKKPKDKA EGGDGKVEPE
KTLAFPGTDS MEVSTSSSLT PAMSISASAS TSQASICSSQ GISQTVSDLS VDPLPAGLEL
PIPPGLLEPH AVSSQESLDI SLCSTGSLGS LGSLGEPLDN AETASVSDMG SMYTVTSLDN
QPLAARPIKG FAVVEIRSRA KIEKIRASLF NNNDLIGLSS LDGEDELMEM STEEILTVSV
VNQSLFDTQG SPGLEDYFND KSIKGEKLVP GAREVLTEIF KSCAHSEQTL SLTPAKPIRV
SDIYLSKEQI NSQTPGNLLH LFFTNVRPPK KVLEDQLTQI LRKYGVPKPK FDKSKYSKAG
KEQHPVKVVS TKRPITKPPA KDKAVLNSVS RTALSEKKPT VKPKSPEKSK PDEKDPEKSP
TKKQEVPEEK YLTLEGFHKF VIDRAKQDIR SVWRAILSCG YDLHFERCAC IDVRHAQKAS
RKWTLEMDVA LVQYINQLCR HLAITPARLH PHEVYLDPAD AADPRVACLL SMWPWAYPLP
CCLMRACPMT RGIYKDVHRT NTYEHLLCAR CARKRLIFYD TKVTVMNRVL NATVQRTADH
AAPEITLDPL EIVGGEIRAS ENSYFCQAAR QLASVPSSQL CVKLASGGDP TYAFNIRFTG
EEVHGTSGSF RHFLWQVCKE LQSSSLSLLL LCPSSAVNKN KGKYILTPSP ITYGEEQLLH
FLGQLLGIAI RADVPLPLDL LPSFWKTLVG EPLDPEQDLQ EADILTYNYV KKFESINDET
ELEALCAEIA SQHLATESPD SPNKPCCRFT YLTMTGEEVE LCSRGRHILV AWENKDIYAA
AIRSLRLREL QNVECVTAVR AGLGSIIPLQ LLTTLSPLEM ELRTCGLPYI NLEFLKAHTM
YQVGLMETDQ HIEFFWGALE MFTQEELCKF IKFACNQERI PFTCPCKDGG PDTAHVPPYP
MKIAPPDGTA GSPDSRYIRV ETCMFMIKLP QYSSLEIMLE KLRCAIHYRE DPLSG
//
