UniProt: A0A2I2ZVI8

Database: UniProt
Entry: A0A2I2ZVI8_GORGO

LinkDB:  A0A2I2ZVI8_GORGO 
Original site:  A0A2I2ZVI8_GORGO

All links

Ontology (1)   
   GO (1)   
Gene (4)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (10)   
   EMBL (10)   
Protein domain (12)   
   InterPro (5)   
   Pfam (1)   
   PROSITE (3)   
   SMART (3)   
Literature (1)   
   PubMed (1)   
All databases (29)   

Download RDF

ID   A0A2I2ZVI8_GORGO        Unreviewed;      1571 AA.
AC   A0A2I2ZVI8;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Neurexin 3 {ECO:0000313|Ensembl:ENSGGOP00000051255.1};
GN   Name=NRXN3 {ECO:0000313|Ensembl:ENSGGOP00000051255.1};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000051255.1, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000051255.1, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000051255.1, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA   Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA   Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA   Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA   Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA   Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA   Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA   Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA   Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA   Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA   Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000051255.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Neuronal cell surface protein that may be involved in cell
CC       recognition and cell adhesion. May mediate intracellular signaling.
CC       {ECO:0000256|ARBA:ARBA00043901}.
CC   -!- SUBCELLULAR LOCATION: Presynaptic cell membrane
CC       {ECO:0000256|ARBA:ARBA00035005}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00035005}.
CC   -!- SIMILARITY: Belongs to the neurexin family.
CC       {ECO:0000256|ARBA:ARBA00010241}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CABD030093384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030093385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030093386; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030093387; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030093388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030093389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030093390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030093391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030093392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030093393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_018865507.1; XM_019009962.1.
DR   Ensembl; ENSGGOT00000045205.1; ENSGGOP00000051255.1; ENSGGOG00000042275.1.
DR   GeneID; 101153807; -.
DR   CTD; 9369; -.
DR   GeneTree; ENSGT00940000154618; -.
DR   OrthoDB; 2999458at2759; -.
DR   Proteomes; UP000001519; Chromosome 14.
DR   Bgee; ENSGGOG00000042275; Expressed in cerebellum and 5 other cell types or tissues.
DR   GO; GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd00054; EGF_CA; 2.
DR   CDD; cd00110; LamG; 6.
DR   Gene3D; 2.60.120.200; -; 6.
DR   Gene3D; 2.10.25.10; Laminin; 3.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR003585; Neurexin-like.
DR   PANTHER; PTHR15036:SF57; NEUREXIN-3; 1.
DR   PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR   Pfam; PF02210; Laminin_G_2; 6.
DR   SMART; SM00294; 4.1m; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00282; LamG; 6.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS50026; EGF_3; 3.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Heparan sulfate {ECO:0000256|ARBA:ARBA00023207};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1498..1518
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          27..202
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          198..235
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          258..440
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          447..639
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          643..680
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          685..857
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          871..1046
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          1049..1086
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1090..1290
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   REGION          1324..1348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1539..1571
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1324..1347
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1553..1571
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1571 AA;  173676 MW;  B76A52056CB31392 CRC64;
     MSSTLHSVFF TLKVSILLGS LLGLCLGLEF MGLPNQWARY LRWDASTRSD LSFQFKTNVS
     TGLLLYLDDG GVCDFLCLSL VDGRVQLRFS MDCAETAVLS NKQVNDSSWH FLMVSRDRLR
     TVLMLDGEGQ SGELQPQRPY MDVVSDLFLG GVPTDIRPSA LTLDGVQAMP GFKGLILDLK
     YGNSEPRLLG SWGVQMDAEG PCGERPCENG GICFLLDGHP TCDCSTTGYG GKLCSEDVSQ
     DPGLSHLMMS EQAREENVAT FRGSEYLCYD LSQNPIQSSS DEITLSFKTW QRNGLILHTG
     KSADYVNLAL KDGAVSLVIN LGSGAFEAIV EPVNGKFNDN AWHDVKVTRN LRQVTISVDG
     ILTTTGYTQE DYTMLGSDDF FYVGGSPSTA DLPGSPVSNN FMGCLKEVVY KNNDIRLELS
     RLARIGDTKM KIYGEVVFKC ENVATLDPIN FETPEAYISL PKWNTKRMGS ISFDFRTTEP
     NGLILFTHGK PQERKDARSQ KNTKVDFFAV ELLDGNLYLL LDMGSGTIKV KATQKKANDG
     EWYHVDIQRD GRSGTISVNS RRTPFTASGE SEILDLEGDM YLGGLPENRA GLILPTELWT
     AMLNYGYVGC IRDLFIDGRS KNIRQLAEMQ NAAGVKSSCS RMSAKQCDSY PCKNNAVCKD
     GWNRFICDCT GTGYWGRTCE REASILSYDG SMYMKIIMPM VMHTEAEDVS FRFMSQRAYG
     LLVATTSRDS ADTLRLELDG GRVKLMVNLD CIRINCNSSK GPETLYAGQK LNDNEWHTVR
     VVRRGKSLKL TVDDDVAEGT MVGDHTRLEF HNIETGIMTE KRYISVVPSS FIGHLQSLMF
     NGLLYIDLCK NGDIDYCELK ARFGLRNIIA DPVTFKTKSS YLSLATLQAY TSMHLFFQFK
     TTSPDGFILF NSGDGNDFIA VELVKGYIHY VFDLGNGPNV IKGNSDRPLN DNQWHNVVIT
     RDNSNTHSLK VDTKVVTQVI NGAKNLDLKG DLYMAGLAQG MYSNLPKLVA SRDGFQGCLA
     SVDLNGRLPD LINDALHRSG QIERGCEGPS TTCQEDSCAN QGVCMQQWEG FTCDCSMTSY
     SGNQCNDPGA TYIFGKSGGL ILYTWPANDR PSTRSDRLAV GFSTTVKDGI LVRIDSAPGL
     GDFLQLHIEQ GKIGVVFNIG TVDISIKEER TPVNDGKYHV VRFTRNGGNA TLQVDNWPVN
     EHYPTGNTDN ERFQMVKQKI PFKYNRPVEE WLQEKGRQLT IFNTQAQIAI GGKDKGRLFQ
     GQLSGLYYDG LKVLNMAAEN NPNIKINGSV RLVGEVPSIL GTTQTTSMPP EMSTTVMETT
     TTMATTTTRK NRSTASIQPT SDDLVSSAEC SSDDEDFVEC EPSTDKSLST SIFEGGYKAH
     APKWESKDFR PNKVSETSRT TTTSLSPELI RFTASSSSGM VPKLPAGKMN NRDLKPQPDI
     VLLPLPTAYE LDSTKLKSPL ITSPMFRNVP TANPTEPGIR RVPGASEVIR ESSSTTGMVV
     GIVAAAALCI LILLYAMYKY RNRDEGSYQV DETRNYISNS AQSNGTLMKE KQQSSKSGHK
     KQKNKDREYY V
//

DBGET integrated database retrieval system